2. Signaling Pathways
  3. Immunology/Inflammation
  4. Aryl Hydrocarbon Receptor
  5. Aryl Hydrocarbon Receptor Antagonist

Aryl Hydrocarbon Receptor Antagonist

Aryl Hydrocarbon Receptor Antagonists (25):

Cat. No. Product Name Effect Purity
  • HY-15001A
    Stemregenin 1 hydrochloride
    		Antagonist
    Stemregenin 1 hydrochloride is a purine derivative that antagonizes aryl hydrocarbon receptor signaling in CD34+ cells. IC50 The value is 127 nM. Stemregenin 1 hydrochloride can be used to expand the pluripotency of hematopoietic stem cells (HSC) in stem cell studies.
  • HY-155061
    hCYP1B1-IN-1
    		Antagonist
    hCYP1B1-IN-1 (compound B18) is a hCYP1B1 inhibitor (IC50=3.6 nM)，as well as an antagonist of Aryl Hydrocarbon Receptor. hCYP1B1-IN-1 exhibtis suitable metabolic stability and good cell-permeability. hCYP1B1-IN-1 inhibits migration of MCF-7 cells.
  • HY-W338764
    AHR agonist 3
    		Antagonist 99.79%
    AHR agonist 3 is an aryl hydrocarbon receptor (AhR) agonist, that can induces cell cycle arrest or apoptosis via activation of tumor-suppressive transcriptional programs. AHR agonist 3 inhibits triple-negative breast cancer (TNBC) stem cell growth via AhR while exhibits minimal cytotoxicity against normal human primary cells and can be used for cancer research.
  • HY-163665
    AHR antagonist 8
    		Antagonist
    AHR antagonist 8 (compound SG-02) is a regulator of utrophin, a homolog of dystrophin, and an AhR antagonist (Kd: 41.68 nM). Studies have shown that 800 nM of AHR antagonist 8 can upregulate utrophin by 2.7 times. AHR antagonist 8 also stimulates increased MyHC expression, suggesting that it has the potential to enhance myogenesis. After ADME evaluation, AHR antagonist 8 also has a certain oral bioavailability.
  • HY-128229
    AHR antagonist 6
    		Antagonist
    AHR antagonist 6 (Compound 44) is an aryl hydrocarbon receptor (AHR) antagonist used in cancer research.