2. Apoptosis Immunology/Inflammation
  3. Apoptosis Aryl Hydrocarbon Receptor
  4. AHR agonist 3

AHR agonist 3 is an aryl hydrocarbon receptor (AhR) agonist, that can induces cell cycle arrest or apoptosis via activation of tumor-suppressive transcriptional programs. AHR agonist 3 inhibits triple-negative breast cancer (TNBC) stem cell growth via AhR while exhibits minimal cytotoxicity against normal human primary cells and can be used for cancer research.

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AHR agonist 3 Chemical Structure

AHR agonist 3 Chemical Structure

CAS No. : 23749-58-8

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AHR agonist 3 Related Antibodies

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Description

AHR agonist 3 is an aryl hydrocarbon receptor (AhR) agonist, that can induces cell cycle arrest or apoptosis via activation of tumor-suppressive transcriptional programs. AHR agonist 3 inhibits triple-negative breast cancer (TNBC) stem cell growth via AhR while exhibits minimal cytotoxicity against normal human primary cells and can be used for cancer research[1].

In Vitro

AHR agonist 3 (Analog 523) (10 nΜ; 24 hour or 2-3 weeks) induces cell cycle arrest and inhibits clonogenicity in AhR WT and AhR KO MDA-MB-468 cells [1].
AHR agonist 3 (0-10 μΜ; 48-72 hours) drives AhR-dependent apoptosis and growth inhibition in breast cancerous cells, but not normal breast epithelial cells or on-tumorigenic cells and inhibits TNBC stem cell growth via AhR.[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AHR agonist 3 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: AhR WT and AhR KO MDA-MB-468 cells
Concentration: 10 nM
Incubation Time: 24 hours or 2−3 weeks
Result: Induced an AhR-dependent S+G2/M phase arrest for Short-term (24 h) treatment.
Completely exhibited the clonogenicity of AhR expressing cells while exhibiting a minimal impact on AhR deficient cells.

Apoptosis Analysis[1]

Cell Line: MDA-MB-468 cells, MCF10A, HEK293T and normal primary human fibroblast
Concentration: 0-10 μΜ
Incubation Time: 48-72 hours
Result: Human mammary epithelial cells (HMECs), nonmalignant mammary epithelial line Induced AhR-dependent apoptosis and growth inhibition in cancerous but not normal cells.
Inhibited TNBC stem cell growth via AhR.
Molecular Weight

270.28

Formula

C18H10N2O
CAS No.
SMILES

C1=CC=C2C(=C1)N=C3C4=CC=CC5=C4C(=CC=C5)C(=O)N23
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References
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AHR agonist 3 Related Classifications

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Keywords:

AHR agonist 323749-58-8AHR agonist3AHR agonist-3ApoptosisAryl Hydrocarbon ReceptorAhRTNBCMDA-MB-468MCF10AHEK293THMECsST2 cellsInhibitorinhibitorinhibit

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