2. Apoptosis Immunology/Inflammation
  3. Apoptosis Aryl Hydrocarbon Receptor
  4. AHR agonist 3

AHR agonist 3 is an aryl hydrocarbon receptor (AhR) agonist, that can induces cell cycle arrest or apoptosis via activation of tumor-suppressive transcriptional programs. AHR agonist 3 inhibits triple-negative breast cancer (TNBC) stem cell growth via AhR while exhibits minimal cytotoxicity against normal human primary cells and can be used for cancer research.

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AHR agonist 3 Chemical Structure

AHR agonist 3 Chemical Structure

CAS No. : 23749-58-8

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AHR agonist 3 Related Antibodies

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Description

AHR agonist 3 is an aryl hydrocarbon receptor (AhR) agonist, that can induces cell cycle arrest or apoptosis via activation of tumor-suppressive transcriptional programs. AHR agonist 3 inhibits triple-negative breast cancer (TNBC) stem cell growth via AhR while exhibits minimal cytotoxicity against normal human primary cells and can be used for cancer research[1].

In Vitro

AHR agonist 3 (Analog 523) (10 nΜ; 24 hour or 2-3 weeks) induces cell cycle arrest and inhibits clonogenicity in AhR WT and AhR KO MDA-MB-468 cells [1].
AHR agonist 3 (0-10 μΜ; 48-72 hours) drives AhR-dependent apoptosis and growth inhibition in breast cancerous cells, but not normal breast epithelial cells or on-tumorigenic cells and inhibits TNBC stem cell growth via AhR.[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AHR agonist 3 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: AhR WT and AhR KO MDA-MB-468 cells
Concentration: 10 nM
Incubation Time: 24 hours or 2−3 weeks
Result: Induced an AhR-dependent S+G2/M phase arrest for Short-term (24 h) treatment.
Completely exhibited the clonogenicity of AhR expressing cells while exhibiting a minimal impact on AhR deficient cells.

Apoptosis Analysis[1]

Cell Line: MDA-MB-468 cells, MCF10A, HEK293T and normal primary human fibroblast
Concentration: 0-10 μΜ
Incubation Time: 48-72 hours
Result: Human mammary epithelial cells (HMECs), nonmalignant mammary epithelial line Induced AhR-dependent apoptosis and growth inhibition in cancerous but not normal cells.
Inhibited TNBC stem cell growth via AhR.
Molecular Weight

270.28

Formula

C18H10N2O
CAS No.
Appearance

Solid

Color

Light yellow to green yellow

SMILES

C1=CC=C2C(=C1)N=C3C4=CC=CC5=C4C(=CC=C5)C(=O)N23
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (37.00 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6999 mL 18.4993 mL 36.9987 mL
5 mM 0.7400 mL 3.6999 mL 7.3997 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.6999 mL 18.4993 mL 36.9987 mL 92.4967 mL
5 mM 0.7400 mL 3.6999 mL 7.3997 mL 18.4993 mL
10 mM 0.3700 mL 1.8499 mL 3.6999 mL 9.2497 mL
15 mM 0.2467 mL 1.2333 mL 2.4666 mL 6.1664 mL
20 mM 0.1850 mL 0.9250 mL 1.8499 mL 4.6248 mL
25 mM 0.1480 mL 0.7400 mL 1.4799 mL 3.6999 mL
30 mM 0.1233 mL 0.6166 mL 1.2333 mL 3.0832 mL
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AHR agonist 3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AHR agonist 323749-58-8AHR agonist3AHR agonist-3ApoptosisAryl Hydrocarbon ReceptorAhRTNBCMDA-MB-468MCF10AHEK293THMECsST2 cellsInhibitorinhibitorinhibit

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