Aurora Kinase

Kinase

Aurora Kinase

Aurora Kinase Isoform Specific Products:

Aurora Kinase Related Products (153)
Antibodies (4)
Aurora Kinase Isoform Comparison

By Effects:	Control (1) Inhibitors (142) Degraders (4) Modulators (2) Chemical (1)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-10971

Alisertib	Inhibitor	99.84%
Alisertib (MLN 8237) is an orally active and selective Aurora A kinase inhibitor (IC₅₀=1.2 nM), which binds to Aurora A kinase resulting in mitotic spindle abnormalities, mitotic accumulation. Alisertib (MLN 8237) induces apoptosis and autophagy through targeting the AKT/mTOR/AMPK/p38 pathway in leukemic cells. Antitumor activity.

HY-10126

Barasertib-HQPA	Inhibitor	99.47%
Barasertib-HQPA (AZD2811) is a highly selective Aurora B inhibitor with an IC₅₀ of 0.37 nM in a cell-free assay. Barasertib-HQPA (AZD2811) induces growth arrest and apoptosis in cancer cells.

HY-10127

Barasertib	Inhibitor	99.62%
Barasertib (AZD1152), a pro-drug of Barasertib-hQPA, is a highly selective Aurora B inhibitor with an IC₅₀ of 0.37 nM in a cell-free assay. Barasertib (AZD1152) induces growth arrest and apoptosis in cancer cells.

HY-14711

Reversine	Inhibitor	99.22%
Reversine is a novel class of ATP-competitive Aurora kinase inhibitor with IC₅₀s of 400, 500 and 400 nM for Aurora A, Aurora B and Aurora C, respectively.

HY-10161

Tozasertib	Inhibitor	99.92%
Tozasertib (VX 680; MK-0457) is an inhibitor of Aurora A/B/C kinases with K_is of 0.6, 18, 4.6 nM, respectively.

HY-168540

PROTAC MPS1 degrader 1	Degrader
PROTAC MPS1 degrader 1 (Compound 19) is a potent degrader of monopolar spindle 1 (Mps1, TTK), AURKA and AURKB, with DC₅₀s of 17.7, 108.7 and 570.3 nM, respectively. PROTAC MPS1 degrader 1 can be used for the research of acute myeloid leukemia. (Pink: ligand for target protein (HY-168542); Black: linker (HY-W141926); Blue: ligand for E3 ligase (HY-10984).

HY-169505

Aurora kinase inhibitor-13	Inhibitor
Aurora kinase inhibitor-13 (Compound 2) is an inhibitor of Aurora kinase, with an IC₅₀ value of 2.3 μM against Aurora kinase A.

HY-168543

PROTAC MPS1 degrader 2	Degrader
PROTAC MPS1 degrader 2 (Compound 15) is a potent degrader of monopolar spindle 1 (Mps1，TTK)，AURKA and AURKB，with DC₅₀s of 42.0，2.1 and 154.0 nM，respectively. PROTAC MPS1 degrader 1 can be used for the research of acute myeloid leukemia. (Pink: ligand for target protein (HY-168545); Black: linker (HY-N0420); Blue: ligand for E3 ligase (HY-10984).

HY-B0712B

Ceftriaxone sodium salt	Inhibitor	99.90%
Ceftriaxone sodium salt (Ro 13-9904) is a broad spectrum β-lactam third-generation cephalosporin antibiotic, which has good antibacterial activity against a variety of gram-negative and positive bacteria. Ceftriaxone sodium salt is a covalent inhibitor of GSK3β with IC₅₀ value of 0.78 μM. Ceftriaxone sodium salt is an inhibitor of Aurora B. Ceftriaxone sodium salt has anti-inflammatory, antitumor and antioxidant activities. Ceftriaxone sodium salt can be used in the study of bacterial infections and meningitis.

HY-10329

JNJ-7706621	Inhibitor	99.91%
JNJ-7706621 is a potent aurora kinase inhibitor, and also inhibits CDK1 and CDK2, with IC₅₀s of 9 nM, 3 nM, 11 nM, and 15 nM for CDK1, CDK2, aurora-A and aurora-B, respectively.

HY-12054

Hesperadin	Inhibitor	98.89%
Hesperadin is an ATP competitive indolinone inhibitor of Aurora A and B. Hesperadin inhibits Aurora B with an IC₅₀ of 250 nM. Hesperadin inhibits the growth of Trypanosoma brucei by blocking nuclear division and cytokinesis. Hesperadin also is a broad-spectrum influenza antiviral.

HY-50514

AT9283	Inhibitor	99.67%
AT9283 is a multi-targeted kinase inhibitor with potent activity against Aurora A/B, JAK2/3, Abl (T315I) and Flt3 (IC₅₀s ranging from 1 to 30 nM). AT9283 inhibits growth and survival of multiple solid tumors in vitro and in vivo.

HY-10339

KW-2449	Inhibitor	99.69%
KW-2449 is a multi-targeted kinase inhibitor of FLT3, ABL, ABL^T315I and Aurora kinase with IC₅₀s of 6.6, 14, 4 and 48 nM, respectively.

HY-13252

MK-5108	Inhibitor	99.89%
MK-5108 is a highly potent and specific inhibitor of Aurora A kinase with an IC₅₀ value of 0.064 nM.

HY-13253

AMG 900	Inhibitor	99.05%
AMG 900 is a potent and highly selective pan-Aurora kinases inhibitor with IC₅₀ of 5 nM, 4 nM and 1 nM for Aurora A, B and C, respectively.

HY-N0110

Palmatine chloride	Inhibitor	99.81%
Palmatine chloride is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor with IC₅₀s of 3 μM and 157μM against HEK 293-hIDO-1 and rhIDO-1, respectively. Palmatine chloride can also inhibit West Nile virus (WNV) NS2B-NS3 protease in an uncompetitive manner with an IC₅₀ of 96 μM. Palmatine chloride shows anti-cancer, anti-oxidation, anti-inflammatory, neuroprotection, antibacterial, anti-viral activities.

HY-10128

ZM-447439	Inhibitor	99.19%
ZM-447439 is an aurora kinase inhibitor with IC₅₀s of 110 and 130 nM for aurora A and B, respectively.

HY-70044

GSK-1070916	Inhibitor	99.55%
GSK-1070916 is a potent and selective ATP-competitive inhibitor of aurora B and aurora C with K_is of 0.38 and 1.5 nM, respectively, and is >250- fold selective over Aurora A.

HY-114258

LY3295668	Inhibitor	99.48%
LY3295668 (AK-01) is a potent, orally active and highly specific Aurora-A kinase inhibitor, with K_i values of 0.8 nM and 1038 nM for AurA and AurB, respectively.

HY-10179

Danusertib	Inhibitor	99.44%
Danusertib is a pyrrolo-pyrazole and aurora kinase inhibitor with IC₅₀ of 13, 79, and 61 nM for Aurora A, B, and C, respectively.

Aurora Kinase Isoform Comparison

Aurora Kinase

Aurora A

Aurora B

Aurora C

Aurora Kinase Degraders & Inhibitors

Product Name	Aurora Kinase	Aurora A	Aurora B	Aurora C	Purity

Alisertib		Aurora A, IC₅₀: 1.2 nM	Aurora B, IC₅₀: 396.5 nM		99.84%
Barasertib-HQPA			Aurora B, IC₅₀: 0.37 nM		99.47%
Barasertib			Aurora B, IC₅₀: 0.37 nM		99.62%
Reversine		Aurora A, IC₅₀: 400 nM	Aurora B, IC₅₀: 500 nM	Aurora C, IC₅₀: 400 nM	99.22%
Tozasertib		Aurora A, Ki: 0.6 nM	Aurora B, Ki: 18 nM	Aurora C, Ki: 4.6 nM	99.92%
PROTAC MPS1 degrader 1		Aurora A, DC₅₀: 108.7 nM	Aurora B, DC₅₀: 570.3 nM
Aurora kinase inhibitor-13		Aurora A, IC₅₀: 2.3 μM
JNJ-7706621		Aurora A, IC₅₀: 11 nM	Aurora B, IC₅₀: 15 nM		99.91%
Hesperadin			Aurora B, IC₅₀: 250 nM		98.89%
AT9283		Aurora A, IC₅₀: 3 nM	Aurora B, IC₅₀: 3 nM		99.67%
KW-2449		Aurora A, IC₅₀: 48 nM			99.69%
MK-5108		Aurora A, IC₅₀: 64 pM			99.89%
AMG 900		Aurora A, IC₅₀: 5 nM	Aurora B, IC₅₀: 4 nM	Aurora C, IC₅₀: 1 nM	99.05%
ZM-447439		Aurora A, IC₅₀: 110 nM	Aurora B, IC₅₀: 130 nM		99.19%
GSK-1070916			Aurora B, Ki: 0.38 nM	Aurora C, Ki: 1.5 nM	99.55%
LY3295668		Aurora A, IC₅₀: 0.8 nM			99.48%
Danusertib		Aurora A, IC₅₀: 13 nM	Aurora B, IC₅₀: 79 nM	Aurora C, IC₅₀: 61 nM	99.44%
PF 477736		Aurora-A, IC₅₀: 23 nM			99.21%
MLN8054		Aurora A, IC₅₀: 4 nM			99.54%
PF-03814735		Aurora 1, IC₅₀: 0.8 nM	Aurora 2, IC₅₀: 5 nM		99.58%
TAK-632			Aurora B, IC₅₀: 66 nM		98.84%
SNS-314 mesylate		Aurora A, IC₅₀: 9 nM	Aurora B, IC₅₀: 31 nM	Aurora C, IC₅₀: 6 nM	99.53%
JB170		Aurora A, DC₅₀: 28 nM Aurora A, Kd: 99 nM Aurora A, EC₅₀: 193 nM			98.97%
ENMD-2076		Aurora A, IC₅₀: 14 nM			99.99%
XL228		Aurora A, IC₅₀: 3.1 nM			99.64%
Ilorasertib hydrochloride		Aurora A, IC₅₀: 120 nM	Aurora B, IC₅₀: 7 nM Aurora B (Y156H), IC₅₀: 12 nM	Aurora C, IC₅₀: 1 nM	98.48%
Cenisertib		Aurora-A	Aurora-B		99.86%
TCS7010		Aurora A, IC₅₀: 3.4 nM	Aurora B, IC₅₀: 3.4 μM		99.82%
SP-96		Aurora A, IC₅₀: 18.975 nM	Aurora B, IC₅₀: 0.316 nM		99.42%
TAK-901		Aurora A, IC₅₀: 21 nM	Aurora B, IC₅₀: 15 nM		99.84%
CCT129202		Aurora A, IC₅₀: 42 nM	Aurora B, IC₅₀: 198 nM	Aurora C, IC₅₀: 227 nM	≥98.0%
BI-847325				Aurora C, IC₅₀: 15 nM	98.15%
CCT 137690		Aurora A, IC₅₀: 15 nM	Aurora B, IC₅₀: 25 nM	Aurora C, IC₅₀: 19 nM	99.54%
GRK2 Inhibitor 2		Aurora A, IC₅₀: 137 nM			98.88%
CYC-116		Aurora A, Ki: 8 nM	Aurora B, Ki: 9.2 nM		99.03%
SCH-1473759 hydrochloride		Aurora A, IC₅₀: 4 nM	Aurora B, IC₅₀: 13 nM		99.79%
GW779439X		Aurora A			99.85%
NU6140		Aurora A, IC₅₀: 67 nM	Aurora B, IC₅₀: 35 nM		99.07%
CD532		Aurora A, IC₅₀: 45 nM			98.78%
MK-8745		Aurora A, IC₅₀: 0.6 nM			99.08%
TAS-119		Aurora A, IC₅₀: 1 nM	Aurora B, IC₅₀: 95 nM		98.03%
Chiauranib			Aurora B, IC₅₀: 9 nM		99.28%
DB0614	Aurora Kinase				98.80%
PHA-680632		Aurora A, IC₅₀: 27 nM	Aurora B, IC₅₀: 135 nM	Aurora C, IC₅₀: 120 nM	98.07%
Aurora kinase inhibitor-3		Aurora A, IC₅₀: 42 nM			99.05%
dAURK-4 hydrochloride		Aurora A			99.44%
GSK2646264		Aurora A, pIC₅₀: <4.3	Aurora B, pIC₅₀: <4.6		98.39%
Aurkin A		Aurora A, Kd: 3.77 μM			≥98.0%
ENMD-2076 Tartrate		Aurora A, IC₅₀: 1.86 nM			99.42%
Ilorasertib		Aurora A, IC₅₀: 120 nM	Aurora B, IC₅₀: 7 nM Aurora B (Y156H), IC₅₀: 12 nM	Aurora C, IC₅₀: 1 nM	99.86%
SCH-1473759		Aurora A, IC₅₀: 4 nM	Aurora B, IC₅₀: 13 nM		98.20%
Aurora kinase inhibitor-2		Aurora A, IC₅₀: 310 nM	Aurora B, IC₅₀: 240 nM		99.08%
CCT241736		Aurora-A, IC₅₀: 38 nM Aurora-A, Kd: 7.5 nM	Aurora-B, Kd: 48 nM		99.88%
AKI603		Aurora A, IC₅₀: 12.3 nM			98.03%
TC-A 2317 hydrochloride		Aurora A, Ki: 1.2 nM	Aurora B, Ki: 101 nM		99.57%
Phthalazinone pyrazole		Aurora-A, IC₅₀: 0.031 μM			≥98.0%
AurkA allosteric-IN-1		Aurora A, IC₅₀: 6.5 μM (^[1])
Alisertib sodium		Aurora A, IC₅₀: 12.5 nM	Aurora B, IC₅₀: 396.5 nM
AT9283 lactic acid		Aurora A, IC₅₀: 3 nM	Aurora B, IC₅₀: 3 nM
Hesperadin hydrochloride			Aurora B, IC₅₀: 250 nM
Aurora inhibitor 1		Aurora A, IC₅₀: 4 nM	Aurora B, IC₅₀: 13 nM
dAURK-4		Aurora A
FAK-IN-22			Aurora B, IC₅₀: 0.49 nM
Aurora A inhibitor 2		Aurora A, IC₅₀: 21.94 nM	Aurora B, IC₅₀: 273.18 nM
RET-IN-19		Aurora A, IC₅₀: 0.242 ± 0. μM	Aurora B, IC₅₀: 0.536 ± 45 μM
SNS-314		Aurora A, IC₅₀: 9 nM	Aurora B, IC₅₀: 31 nM	Aurora C, IC₅₀: 6 nM
Aurora kinase inhibitor-10			Aurora B, IC₅₀: 8 nM
Glycyl H-1152 hydrochloride		Aurora A, IC₅₀: 2.35 μM
Aurora A/PKC-IN-1		Aurora A, IC₅₀: 6.9 nM
Aurora kinase-IN-5		Aurora A, IC₅₀: 5.6 nM	Aurora B, IC₅₀: 18.4 nM	Aurora C, IC₅₀: 24.6 nM
Aurora kinase-IN-2		Aurora A, IC₅₀: 90 nM	Aurora B, IC₅₀: 152 nM
Aurora kinase inhibitor-9		Aurora A, IC₅₀: 0.093 μM	Aurora B, IC₅₀: 0.09 μM
BRD-7880		Aurora A, IC₅₀: 2153 nM	Aurora B, IC₅₀: 7 nM	Aurora C, IC₅₀: 12 nM
SAR156497		Aurora A, IC₅₀: 0.6 nM	Aurora B, IC₅₀: 1 nM
TAK-901 hydrochloride		Aurora A, IC₅₀: 21 nM	Aurora B, IC₅₀: 15 nM
(Rac)-Aurora A/PKC-IN-1		Aurora A, IC₅₀: 6.9 nM
Benzo[c][1,8]naphthyridin-6(5H)-one		Aurora A, IC₅₀: 5.5 μM
TY-011		Aurora A	Aurora B
Binucleine 2			Aurora B
Aurora A inhibitor 4		Aurora A
Aurora B inhibitor 1			Aurora B, Ki: 0.01 μM

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Aurora Kinase

Aurora Kinase

Aurora Kinase Isoform Specific Products:

Aurora Kinase Isoform Specific Products:

Aurora Kinase Related Products (153)

Antibodies (4)

Aurora Kinase Isoform Comparison

Aurora Kinase Related Products (153):