GRK6-IN-1

Cat. No.: HY-142812 Purity: 99.64%: FAQs
Data Sheet SDS COA Handling Instructions

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GRK6-IN-1 (compound 18) is a potent inhibitor of G protein-coupled receptor kinase 6 (GRK6) with an IC₅₀ of 120 nM. GRK6 is a critical kinase required for the survival of multiple myeloma (MM) cells. GRK6-IN-1 has the potential for the research of multiple myeloma.

For research use only. We do not sell to patients.

GRK6-IN-1 Chemical Structure

CAS No. : 2677786-61-5

Size	Price	Stock	Quantity

Free Sample (0.1 - 0.5 mg)		Apply Now
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 165	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 165	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 150	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 250	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 550	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 950	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 1550	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 2 publication(s) in Google Scholar

2 Publications Citing Use of MCE GRK6-IN-1

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Biological Activity
Purity & Documentation
References
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Description

Cellular Effect

Cell Line	Type	Value	Description	References
KMS-11	IC₅₀	0.34 μM Compound: 18	Antiproliferative activity against human KMS11 cells expressing pWPI assessed as reduction in cell viability incubated for 6 days by MTT assay Antiproliferative activity against human KMS11 cells expressing pWPI assessed as reduction in cell viability incubated for 6 days by MTT assay	[PMID: 34291633]
KMS-11	IC₅₀	0.44 μM Compound: 18	Antiproliferative activity against human KMS11 cells overexpressing pWPI-GRK6A assessed as reduction in cell viability incubated for 6 days by MTT assay Antiproliferative activity against human KMS11 cells overexpressing pWPI-GRK6A assessed as reduction in cell viability incubated for 6 days by MTT assay	[PMID: 34291633]
KMS-11	IC₅₀	1 μM Compound: 18	Antiproliferative activity against human KMS11 cells assessed as reduction in cell viability incubated for 3 days by MTT assay Antiproliferative activity against human KMS11 cells assessed as reduction in cell viability incubated for 3 days by MTT assay	[PMID: 34291633]
KMS-11	IC₅₀	1 μM Compound: 18	Antiproliferative activity against human KMS11 cells expressing pWPI assessed as reduction in cell viability incubated for 3 days by MTT assay Antiproliferative activity against human KMS11 cells expressing pWPI assessed as reduction in cell viability incubated for 3 days by MTT assay	[PMID: 34291633]
KMS-11	IC₅₀	1.1 μM Compound: 18	Antiproliferative activity against human KMS11 cells overexpressing pWPI-GRK6A assessed as reduction in cell viability incubated for 3 days by MTT assay Antiproliferative activity against human KMS11 cells overexpressing pWPI-GRK6A assessed as reduction in cell viability incubated for 3 days by MTT assay	[PMID: 34291633]
LP-1	IC₅₀	1.9 μM Compound: 18	Antiproliferative activity against human LP1 cells assessed as reduction in cell viability incubated for 3 days by MTT assay Antiproliferative activity against human LP1 cells assessed as reduction in cell viability incubated for 3 days by MTT assay	[PMID: 34291633]
RPMI-8226	IC₅₀	0.44 μM Compound: 18	Antiproliferative activity against human RPMI-8226 cells assessed as reduction in cell viability incubated for 6 days by MTT assay Antiproliferative activity against human RPMI-8226 cells assessed as reduction in cell viability incubated for 6 days by MTT assay	[PMID: 34291633]
RPMI-8226	IC₅₀	2.1 μM Compound: 18	Antiproliferative activity against human RPMI-8226 cells assessed as reduction in cell viability incubated for 3 days by MTT assay Antiproliferative activity against human RPMI-8226 cells assessed as reduction in cell viability incubated for 3 days by MTT assay	[PMID: 34291633]

Molecular Weight

438.91

Formula

C₂₂H₂₃ClN₆O₂

CAS No.

2677786-61-5

Appearance

Solid

Color

White to off-white

SMILES

COC1=CC=CC2=NC(NCC3=CC=C(Cl)C=C3OC)=NC(NC4=NNC(CC)=C4)=C12

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (113.92 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.2784 mL	11.3919 mL	22.7837 mL
5 mM	0.4557 mL	2.2784 mL	4.5567 mL
10 mM	0.2278 mL	1.1392 mL	2.2784 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.64%

Select Batch:

Data Sheet (276 KB) SDS (251 KB)

COA (254 KB) HNMR (287 KB) LCMS (96 KB)

Handling Instructions (2659 KB)

References

[1]. Uehling DE, et al. Design, Synthesis, and Characterization of 4-Aminoquinazolines as Potent Inhibitors of the G Protein-Coupled Receptor Kinase 6 (GRK6) for the Treatment of Multiple Myeloma [published correction appears in J Med Chem. 2022 Jan 13;65(1):886-887]. J Med Chem. 2021;64(15):11129-11147. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.2784 mL	11.3919 mL	22.7837 mL	56.9593 mL
	5 mM	0.4557 mL	2.2784 mL	4.5567 mL	11.3919 mL
	10 mM	0.2278 mL	1.1392 mL	2.2784 mL	5.6959 mL
	15 mM	0.1519 mL	0.7595 mL	1.5189 mL	3.7973 mL
	20 mM	0.1139 mL	0.5696 mL	1.1392 mL	2.8480 mL
	25 mM	0.0911 mL	0.4557 mL	0.9113 mL	2.2784 mL
	30 mM	0.0759 mL	0.3797 mL	0.7595 mL	1.8986 mL
	40 mM	0.0570 mL	0.2848 mL	0.5696 mL	1.4240 mL
	50 mM	0.0456 mL	0.2278 mL	0.4557 mL	1.1392 mL
	60 mM	0.0380 mL	0.1899 mL	0.3797 mL	0.9493 mL
	80 mM	0.0285 mL	0.1424 mL	0.2848 mL	0.7120 mL
	100 mM	0.0228 mL	0.1139 mL	0.2278 mL	0.5696 mL

GRK6-IN-1 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GRK6-IN-12677786-61-5G Protein-coupled Receptor Kinase (GRK)GRK6multiple myelomasurvivalInhibitorinhibitorinhibit

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GRK6-IN-1

Customer Review

GRK6-IN-1 Related Antibodies

2 Publications Citing Use of MCE GRK6-IN-1

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity

Purity & Documentation

References

Customer Review

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

GRK6-IN-1 Related Classifications

Keywords:

Your Recently Viewed Products:

Customer Review

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SAFETY DATA SHEET (SDS)

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