2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. CDK
  5. CDK2 Isoform
  6. CDK2 Degrader

CDK2 Degrader

CDK2 Degraders (5):

Cat. No. Product Name Effect Purity
  • HY-164827
    CDK2 degrader 3
    		Degrader
    CDK2 degrader 3 can selectively degrade CDK2 and has anti-tumor activity.
  • HY-155218
    TMX-2172
    		Degrader
    TMX-2172 is a PROTACs degrader for CDK2 and CDK5, with the IC50s of 6.5 and 6.8 nM, respectively. TMX-2172 plays an important role in cancer research (Blue: E3 ligase ligand (HY-W008352); Pink: target protein ligand (HY-170748); Black: linker (HY-151072)).
  • HY-169912
    CDK2 degrader 5
    		Degrader
    CDK2 degrader 5 (compound 12) is a degrader for CDK2, with the Dmax of >50% and ≤80% in HiBiT Assay. CDK2 degrader 5 plays an important role in cancer research.
  • HY-161708
    PROTAC FLT3/CDKs degrader-1
    		Degrader
    PROTAC FLT3/CDKs degrader-1 (Compound C3) is a degrader for cyclin-dependent kinases (DC50 is 18.73 nM for CDK2) and the FMS-like tyrosine kinase 3 (FLT3). PROTAC FLT3/CDKs degrader-1 induces differentation of HL-60 (72.77% differentation at 6.25 nM), inhibits proliferation of AML cells, with IC50s of 2.9-37 nM. PROTAC FLT3/CDKs degrader-1 is potential for ameliorating acute myeloid leukemia. (Pink: ligand for target protein FLT3/CDKs ligand-1 (HY-161709); Black: linker (HY-W012935); Black: ligand for E3 ligase Thalidomide 5-fluoride (HY-W087383))
  • HY-164906
    TMX-2138
    		Degrader
    TMX-2138 is a CDKs PROTAC degrader, with IC50s of 8.7 nM, 10.9 nM, 7.0 nM and 25.7 nM for CDK1/cyclinB, CDK2/cyclinA, CDK5/p25 and CDK9/cyclinT1, respectively. TMX-2138 promotes ubiquitination and degradation of CDKs. TMX-2138 can be used for the research of ovarian cancer (Pink: CDKs ligand (HY-151071); Blue: E3 ligase CRBN ligand (HY-14658); Black: linker (HY-W008352)).