2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. CDK
  5. CDK2 Isoform
  6. CDK2 Degrader

CDK2 Degrader

CDK2 Degrader (1):

Cat. No. Product Name Effect Purity
  • HY-161708
    PROTAC FLT3/CDKs degrader-1
    		Degrader
    PROTAC FLT3/CDKs degrader-1 (Compound C3) is a degrader for cyclin-dependent kinases (DC50 is 18.73 nM for CDK2) and the FMS-like tyrosine kinase 3 (FLT3). PROTAC FLT3/CDKs degrader-1 induces differentation of HL-60 (72.77% differentation at 6.25 nM), inhibits proliferation of AML cells, with IC50s of 2.9-37 nM. PROTAC FLT3/CDKs degrader-1 is potential for ameliorating acute myeloid leukemia. (Pink: ligand for target protein FLT3/CDKs ligand-1 (HY-161709); Black: linker (HY-W012935); Black: ligand for E3 ligase Thalidomide 5-fluoride (HY-W087383))