CRFR Antagonist

CRFR Antagonists (31):

Cat. No.	Product Name	Effect	Purity

HY-103377

Antalarmin hydrochloride	Antagonist	99.87%
Antalarmin (hydrochloride) is an oral active non-peptide corticotropin-releasing hormone receptor 1 (CRHR1) antagonist with a K_i of 1 nM. Antalarmin hydrochloride suppresses CRH-induced ACTH secretion and blocks CRH and novelty induced anxiety-like behavior in animal models. Antalarmin hydrochloride produces anti-inflammatory effects in arthritis models, and suppresses stress-induced gastric ulceration related to irritable bowel syndrome.

HY-14127

R121919	Antagonist	99.53%
R121919 (NBI30775) is a potent and selective CRF1R antagonist with a K_i of 2 to 5 nM. R121919 has antidepressant and anxiolytic effects. R121919 alleviates defensive withdrawal in rats.

HY-14875

Verucerfont	Antagonist	99.51%
Verucerfont is a corticotropin-releasing factor receptor 1 (CRF1) antagonist with IC₅₀s of ~6.1, >1000 and >1000 nM for CRF1, CRF2, and CRF-BP, respectively.

HY-135542

NBI-27914	Antagonist	99.82%
NBI-27914 is a potent and selective antagonist of CRFR1. The CRF receptors, CRFR1 and CRFR2, are members of the G protein-coupled receptor superfamily.

HY-120564

BMS-763534	Antagonist
BMS-763534 is a CRF1 antagonist that inhibits neurological disorders such as depression and anxiety..

HY-123677

E2508	Antagonist
E2508 is an orally active corticotropin-releasing factor 1 (CRF1) receptor antagonist with a K_i value of 11 nM for hCRF1.

HY-105332

CRA1000	Antagonist
CRA1000 is an orally active, selective and competitive CRF1 receptor antagonist with anxiolytic- and antidepressant-like properties.

HY-P1107A

Antisauvagine-30 TFA	Antagonist	98.10%
Antisauvagine-30 TFA (aSvg-30 TFA) is a potent, highly selective and competitive CRF₂ receptor peptidic antagonist. Antisauvagine-30 TFA exhibits a K_d of 1.4 nM and 150 nM for mCRFR2β and CRFR1, respectively.

HY-14130

CP 376395	Antagonist	99.68%
CP 376395 is a potent, selective, and brain-penetrable Corticotropin releasing factor 1 (CRF1) receptor antagonist.

HY-12127

Pexacerfont	Antagonist	99.97%
Pexacerfont is a selective corticotropin-releasing factor (CRF₁) receptor antagonist with IC₅₀ of 6.1±0.6 nM for human CRF₁ receptor.

HY-124475

Antalarmin	Antagonist
Antalarmin is a selective nonpeptide corticotropin-releasing factor receptor 1 (CRHR1) antagonist with a K_i of 2.7 nM. Antalarmin can pass through the blood–brain barrier.

HY-12131

DMP 696	Antagonist	99.03%
DMP 696 is a selective corticotropin-releasing hormone receptor 1 (CRHR1) antagonist, used for the treatment of anxiety and depression.

HY-103376

NBI-27914 hydrochloride	Antagonist
NBI-27914 (hydrochloride) is a selective Corticotropin-Releasing Factor 1 (CRF1) receptor antagonist with a K_i value of 1.7 nM.

HY-14367

Emicerfont	Antagonist	98.03%
Emicerfont is a corticotropin-releasing factor type 1 (CRF₁) receptor antagonist with an IC₅₀ of 66 nM.

HY-12339

NVS-CRF38	Antagonist
NVS-CRF38 is a novel corticotropin-releasing factor receptor 1 (CRF1) antagonist with low water solubility.

HY-115645

R121919 hydrochloride	Antagonist
R121919 (NBI30775) hydrochloride is a potent and selective CRF1R antagonist with a K_i of 2 to 5 nM. R121919 hydrochloride has antidepressant and anxiolytic effects. R121919 hydrochloride alleviates defensive withdrawal in rats.

HY-P1106

K41498	Antagonist
K41498 is a potent and highly selective CRF2 receptor antagonist with K_i values of 0.66 nM, 0.62 nM and 425 nM for human CRF_2α, CRF_2β and CRF₁ receptors respectively. K41498 is an analogues of antisauvagine-30 (aSvg-30), inhibits sauvagine-stimulated cAMP accumulation in hCRF_2α- and hCRF_2β-expressing cells. K41498 can be used for hypotension study.

HY-12130

CP 154526	Antagonist
CP 154526 is a potent, brain-penetrant and selective corticotropin-releasing factor receptor 1 (CRF1) antagonist with a K_i of 2.7 nM. CP 154526 shows selective for CRF1 over CRF2 (K_i = >10 μM). CP 154526 has anxiolytic activities.

HY-103379

CP 376395 hydrochloride	Antagonist
CP 376395 hydrochloride is a potent, selective, and brain-penetrable Corticotropin releasing factor 1 (CRF1) receptor antagonist.

HY-14132

BMS-665053	Antagonist
BMS-665053 is a corticotropin-releasing factor-1 (CRF1) receptor antagonist (IC₅₀ = 1.0 nM). BMS-665053)11 is a potent inhibitor of CRF-stimulated cyclic adenosine monophosphate (cAMP) production in human Y-79 retinoblastoma cells (IC₅₀ = 4.9 nM).

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