2. Signaling Pathways
  3. Neuronal Signaling
  4. Calcineurin

Calcineurin

PP2B; PPP3

 
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-125862
    Glutathione Reductase, baker's yeast
    		Inhibitor
    Glutathione reductase (EC 1.6.4.2) (EC 1.6.4.2) is a reductase responsible for maintaining the supply of reduced glutathione.
    Glutathione Reductase, baker's yeast
  • HY-W181102
    NFAT Inhibitor-2
    		Inhibitor 98.02%
    NFAT Inhibitor-2 is a potent inhibitor of calcineurin NFAT signalling. Calcineurin is a serine/threonine protein phosphatase regulated by Ca2+ and calmodulin. NFAT Inhibitor-2 has the potential for the research of inflammatory disease, an autoimmune disorder, a cardiovascular disease, a neurodegenerative disease, a disease occurring with uncontrolled cell proliferation and/or differentiation, an angiogenesis-related disease, an allergy, anaphylaxis and alopecia (extracted from patent WO2016207212A1, compound 17).
    NFAT Inhibitor-2
  • HY-P1355A
    Cyclosporin A-Derivative 1 Free base
    		Inhibitor 98.80%
    Cyclosporin A-Derivative 1 (Free base) is a crystalline intermediate derived from the opening of cyclosporin A extracted from patent WO 2013167703 A1. Cyclosporin A is an immunosuppressive agent which can bind to the cyclophilin and inhibit calcineurin.
    Cyclosporin A-Derivative 1 Free base
  • HY-148992
    APX879
    		Inhibitor
    APX879 is a fungal-specific calcineurin inhibitor that has less immunosuppressive activities and toxicities. APX879 is a C22-modified FK506 (HY-13756) analog, which maintains broad-spectrum antifungal activity.
    APX879
  • HY-B0579S3
    Cyclosporin A-13C2,d4
    		Inhibitor
    Cyclosporin A-13C2,d4 (Cyclosporine A-13C2,d4; Ciclosporin A-13C2,d4) is a 13C labeled Cyclosporin A (HY-B0579). Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of protein phosphatase 2B (PP2B/calcineurin) with an IC50 of 5 nM. Cyclosporin A also inhibits CD11a/CD18 adhesion.
    Cyclosporin A-<sup>13</sup>C<sub>2</sub>,d<sub>4</sub>
  • HY-B0579S2
    Cyclosporin A acetate-d4
    		Inhibitor 99.90%
    Cyclosporin A acetate-d4 (Cyclosporine A acetate-d4; Ciclosporin A acetate-d4) is a deuterium labeled Cyclosporin A (HY-B0579). Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of protein phosphatase 2B (PP2B/calcineurin) with an IC50 of 5 nM. Cyclosporin A also inhibits CD11a/CD18 adhesion.
    Cyclosporin A acetate-d<sub>4</sub>
  • HY-P1354
    Cyclosporin A-Derivative 2
    		Inhibitor
    Cyclosporin A-Derivative 2 is a novel derivative from cyclosporin A. Cyclosporin A is an immunosuppressive agent which can bind to the cyclophilin and inhibit calcineurin.
    Cyclosporin A-Derivative 2
  • HY-N9736
    6,4'-Dihydroxy-7-methoxyflavanone
    		Inhibitor
    6,4'-Dihydroxy-7-methoxyflavanone, a flavonoid, is a nature product that could be isolated from Heartwood Dalbergia odorifera. 6,4'-Dihydroxy-7-methoxyflavanone inhibits receptor activators of nuclear factor kappa-B ligand (RANKL) induced osteoclastogenesis. 6,4'-Dihydroxy-7-methoxyflavanone has antioxidant, anti-inflammatory and neuroprotective effects. 6,4'-Dihydroxy-7-methoxyflavanone can be used in research of osteoporosis.
    6,4'-Dihydroxy-7-methoxyflavanone
  • HY-P1355
    Cyclosporin A-Derivative 1
    		Inhibitor
    Cyclosporin A-Derivative 1 is a crystalline intermediate derived from the opening of cyclosporin A extracted from patent WO 2013167703 A1. Cyclosporin A is an immunosuppressive agent which can bind to the cyclophilin and inhibit calcineurin.
    Cyclosporin A-Derivative 1
Cat. No. Product Name / Synonyms Application Reactivity