2. Signaling Pathways
  3. Neuronal Signaling
  4. Calcineurin
  5. Calcineurin Inhibitor

Calcineurin Inhibitor

Calcineurin Inhibitors (8):

Cat. No. Product Name Effect Purity
  • HY-125862
    Glutathione Reductase, baker's yeast
    		Inhibitor
    Glutathione reductase, baker's yeast (EC 1.6.4.2) is a reductase. Glutathione reductase, baker's yeast eliminates intracellular ROS. Glutathione reductase, baker's yeast reduces oxidized glutathione (GSSG) to reduced glutathione (GSH) using NADPH as an electron donor. Glutathione reductase, baker's yeast exerts antioxidant activity. Glutathione reductase is mainly used to study diseases associated with oxidative stress, such as Parkinson's disease and sickle cell anemia.
  • HY-W181102
    NFAT Inhibitor-2
    		Inhibitor 98.02%
    NFAT Inhibitor-2 is a potent inhibitor of calcineurin NFAT signalling. Calcineurin is a serine/threonine protein phosphatase regulated by Ca2+ and calmodulin. NFAT Inhibitor-2 has the potential for the research of inflammatory disease, an autoimmune disorder, a cardiovascular disease, a neurodegenerative disease, a disease occurring with uncontrolled cell proliferation and/or differentiation, an angiogenesis-related disease, an allergy, anaphylaxis and alopecia (extracted from patent WO2016207212A1, compound 17).
  • HY-P1355A
    Cyclosporin A-Derivative 1 Free base
    		Inhibitor 98.80%
    Cyclosporin A-Derivative 1 (Free base) is a crystalline intermediate derived from the opening of cyclosporin A extracted from patent WO 2013167703 A1. Cyclosporin A is an immunosuppressive agent which can bind to the cyclophilin and inhibit calcineurin.
  • HY-148992
    APX879
    		Inhibitor
    APX879 is a fungal-specific calcineurin inhibitor that has less immunosuppressive activities and toxicities. APX879 is a C22-modified FK506 (HY-13756) analog, which maintains broad-spectrum antifungal activity.
  • HY-P1354
    Cyclosporin A-Derivative 2
    		Inhibitor
    Cyclosporin A-Derivative 2 is a novel derivative from cyclosporin A. Cyclosporin A is an immunosuppressive agent which can bind to the cyclophilin and inhibit calcineurin.
  • HY-135700
    Mevalonolactone
    		Inhibitor ≥98.0%
    Mevalonolactone is a sesquiterpene lactone that displays calcineurin inhibitory activity towards p-Nitrophenyl phosphate (HY-116022) (IC50 of 134.29 μM).
  • HY-N9736
    6,4'-Dihydroxy-7-methoxyflavanone
    		Inhibitor
    6,4'-Dihydroxy-7-methoxyflavanone, a flavonoid, is a nature product that could be isolated from Heartwood Dalbergia odorifera. 6,4'-Dihydroxy-7-methoxyflavanone inhibits receptor activators of nuclear factor kappa-B ligand (RANKL) induced osteoclastogenesis. 6,4'-Dihydroxy-7-methoxyflavanone has antioxidant, anti-inflammatory and neuroprotective effects. 6,4'-Dihydroxy-7-methoxyflavanone can be used in research of osteoporosis.
  • HY-P1355
    Cyclosporin A-Derivative 1
    		Inhibitor
    Cyclosporin A-Derivative 1 is a crystalline intermediate derived from the opening of cyclosporin A extracted from patent WO 2013167703 A1. Cyclosporin A is an immunosuppressive agent which can bind to the cyclophilin and inhibit calcineurin.