Carbonic Anhydrase

Carbonic Anhydrase Related Products (150):

By Effects:	Inhibitors (141) Modulator (1)

Cat. No.	Product Name	Effect	Purity

HY-108316

Sultiame	Inhibitor	99.11%
Sultiame is a carbonic anhydrase inhibitor, widely used as an antiepileptic agent.

HY-123179

Mefruside	Inhibitor	≥99.0%
Mefruside is an orally active diuretic and has a mild hypotensive effect. Mefruside inhibits the synthesis of urea in an isolated rat liver perfusion model. Mefruside can be used in studies of oedema and hypertension.

HY-B0109

Dorzolamide	Inhibitor
Dorzolamide (L671152) is a potent carbonic anhydrase II inhibitor, with IC₅₀ values of 0.18 nM and 600 nM for red blood cell CA-II and CA-I respectively. Dorzolamide possesses anti-tumor activity.

HY-B0124A

Zonisamide sodium	Inhibitor
Zonisamide (AD 810) sodium is an orally active carbonic anhydrase inhibitor, with K_is of 35.2 and 20.6 nM for hCA II and hCA V, respectively. Zonisamide sodium exerts neuroprotective effects through anti-apoptosis and upregulating MnSOD levels. Zonisamide sodium also increases the expression of Hrd1, thereby improving cardiac function in AAC rats. Zonisamide sodium can be used in studies of seizure, parkinson’s disease and cardiac hypertrophy.

HY-B0124S

Zonisamide-d₄	Inhibitor	99.38%
Zonisamide-d₄ is the deuterium labeled Zonisamide. Zonisamide (AD 810) is an inhibitor of zinc enzyme carbonic anhydrase (CA), with Kis of 35.2 nM and 20.6 nM for human mitochondrial isozyme hCA II and hCA V, respectively. Zonisamide has antiepileptic activity. Zonisamide can be used for the rsearch for epilepsy, seizures and Parkinson's disease[1][2].

HY-B0283A

Acipimox sodium
Acipimox (K-9321) sodium, a nicotinic acid analogue, is an antilipolytic compound. Acipimox sodium stimulates leptin releas, inhibits lipolysis and suppresses systemic levels of free fatty acids (FFAs) and improves insulin sensitivity.

HY-147986

hCA I-IN-2	Inhibitor
hCA I-IN-2 (Compound 6d) is a selective human carbonic anhydrase I (hCA I) inhibitor with K_i values of 18.8, 375.1, 1721 and 283.9 nM against hCA I, hCA II, hCAIX and hCAXII, respectively.

HY-B0122A

Topiramate lithium	Inhibitor
Topiramate (McN 4853) lithium is a broad-spectrum antiepileptic agent. Topiramate lithium is a GluR5 receptor antagonist. Topiramate produces its antiepileptic effects through enhancement of GABAergic activity, inhibition of kainate/AMPA receptors, inhibition of voltage-sensitive sodium and calcium channels, increases in potassium conductance, and inhibition of carbonic anhydrase.

HY-155522

WES-1	Inhibitor
WES-1 (Compound 8g) is an inhibitor of carbonic anhydrase IX (K_i: 55.9 μM). WES-1 has broad spectrum anti-proliferative activity against the cancer cells, such as leukemia (K-562 and MOLT-4), non-small cell lung cancer (NCI–H460), colon cancer (HCT 116 and HCT-15) and melanoma (LOX IMVI) cell lines.

HY-168124

Carbonic anhydrase inhibitor 26	Inhibitor
Carbonic anhydrase inhibitor 26 (compund 6T) is a carbonic anhydrase II inhibitor with IC₅₀ of 9.10 ± 0.26 μM.

HY-155271

hCAXII-IN-7	Inhibitor
hCAXII-IN-7 (compound 6e) is a hCA XII inhibitor. hCAXII-IN-7 has BBB permeability. hCAXII-IN-7 induces 786-0, SF-539 and HS 578 T cells apoptotic.

HY-161174

Carbonic anhydrase inhibitor 17	Inhibitor
Carbonic anhydrase inhibitor 17 (compound 7c) ,pyridazine-tethered sulfonamide, is a carbonic anhydrase II inhibitor with IC₅₀ of 0.63 nM.

HY-155760

hCA/VEGFR-2-IN-3	Inhibitor
hCA/VEGFR-2-IN-3 (compound 8j) is an indolinonylbenzenesulfonamide and a potential dual inhibitor of cancer-associated hCA IX/XII and VEGFR-2. hCA/VEGFR-2-IN-3 inhibits VEGFR-2 (IC₅₀=358 nM), has high binding activity to hCAs with Ki of 4.2 nM (hCA IX), 22.9 nM (hCA II), 25.1 nM (hCA I), 28.0 nM (hCA XII), respectively. hCA/VEGFR-2-IN-3 has antiproliferative activity against VEGFR-2 overexpressing breast cancer cells.

HY-120677

AHR-15010	Inhibitor
AHR-15010 is an oral active carbonic anhydrase inhibitor with the IC₅₀ of 0.13 μM. AHR-15010 shows anti-arthritic activity and can be used for study of arthritis .

HY-156013

CA inhibitor 2	Inhibitor
CA inhibitor 2 (Compound 4H) is a carbonic anhydrase inhibitor (IC₅₀: 0.033 μM).

HY-147828

hCAIX-IN-11	Inhibitor
hCAIX-IN-11 (Compound 5d) is a selective carbonic anhydrase IX and XII inhibitor with K_i s of 32.7 and 623.5 nM for hCA IX and hCA XII, respectively. hCA IX and hCA XII are transmembrane isoforms which have been characterized as biomarkers for several types of tumors. The hCA XII assists in maintenance of acid-base homoeostasis in normal as well as tumor cells.

HY-19213

L-693612	Inhibitor
L-693612 (Compd 1) is an orally active and topical carbonic anhydrase inhibitor.

HY-146983

hCAIX-IN-3	Inhibitor
hCAII-IN-3 (compound 7e) is a potent and selective inhibitor of carbonic anhydrase (CA II/IX) with K_is of 124.2 and 30.5 nM, respectively. hCAII-IN-3 has the potential for the research of cancer diseases.

HY-126117

(+)-Xylariamide A	Inhibitor
(+)-Xylariamide A (compound 6b) is a mycobacterial and fungal carbonic anhydrase probe with inhibitory activity against pathogen β-carbonic anhydrases.

HY-155694

hCA/VEGFR-2-IN-1	Inhibitor
hCA/VEGFR-2-IN-1 (compound 13a) is a potent dual Carbonic Anhydrase(CA) IX/XII with K_i values of 4.7 nM and 8.3 nM for hCA XII and hCA IX, respectively. hCA/VEGFR-2-IN-1 (compound 13a) is a potent VEGFR-2 inhibitor with IC₅₀ values 26.3 nM. hCA/VEGFR-2-IN-1 has anticancer activity.

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