ERK

ERK Related Products (279):

By Type:	Pan (26) Selective (3)
By Effects:	Inhibitors (177) Control (1) Agonists (5) Activators (55) Modulators (6) Chemical (1) Inducers (7)

Cat. No.	Product Name	Effect	Purity

HY-145028

ERK1/2 inhibitor 6	Inhibitor
ERK1/2 inhibitor 6 is a potent inhibitor of ERK1/2. Mitogen-activated protein kinase (MAPK) plays an extremely important role in the signal transduction pathway, and extracellular signal regulated kinase (ERK) is a member of the MAPK family. ERK1/2 inhibitor 6 has the potential for the research or prevention of cancer, inflammation or other proliferative diseases (extracted from patent WO2021063335A1, compound 1).

HY-N10802

6-O-Isobutyrylbritannilactone	Inhibitor
6-O-Isobutyrylbritannilactone is a natural melanogenesis inhibitor. 6-O-Isobutyrylbritannilactone, a sesquiterpene, can be isolated from the flowers of Inula britannica. 6-O-Isobutyrylbritannilactone inhibits IBMX (HY-12318)-induced melanin production in B16F10 cells. 6-O-Isobutyrylbritannilactone also regulates ERK, PI3K/AKT, and CREB, shows antimelanogenic activity in zebrafish embryos models.

HY-N6246R

Asperulosidic Acid (Standard)	Inhibitor
Asperulosidic Acid (Standard) is the analytical standard of Asperulosidic Acid. This product is intended for research and analytical applications. Asperulosidic Acid (ASPA), a bioactive iridoid glycoside, is extracted from the herbs of Hedyotis diffusa Willd. Asperulosidic Acid (ASPA) has anti-tumor, anti-oxidant, and anti-inflammatory activities. ASPA is related to the inhibition of inflammatory cytokines (TNF-α, IL-6) and mediators via suppression of the NF-κB and mitogen-activated protein kinase (MAPK) signaling pathways.

HY-W011727AR

Pyridoxal 5'-phosphate (monohydrate) (Standard)	Activator

HY-169332

Piezo1 agonist 1-d₂	Activator
Piezo1 agonist 1-d₂ (Compound 12a) is an agonist for Piezo1 with an EC₅₀ of 2.21 μM. Piezo1 agonist 1-d₂ activates the Ca²⁺-related ERK signaling pathway, and thus promotes the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs). Piezo1 agonist 1-d₂ ameliorates disuse osteoporosis in the hindlimb-unloading (HU) rat model.

HY-B1037R

Salbutamol (Standard)	Activator
Salbutamol (Standard) is the analytical standard of Salbutamol. This product is intended for research and analytical applications. Salbutamol (Albuterol) is a short-acting beta-2 adrenergic receptor agonist with oral activity. Salbutamol promotes tumorigenesis of gastric cancer cells through the β2-AR/ERK/EMT pathway. Salbutamol is used to study bronchospasms caused by asthma and chronic obstructive pulmonary disease (COPD).

HY-144253

AKT-IN-11
AKT-IN-11 is one of the most effective antibacterial agents against human hepatoma BEL-7402 cell line with an IC₅₀ value of 1.15μM.

HY-P4159B

Endothelin-1 (1-31) (Human) acetate	Activator
Endothelin-1 (1-31) (Human) acetate is a potent vasoconstrictor and hypertensive agent. Endothelin-1 (1-31) (Human) acetate is derived from the selective hydrolysis of big ET-1 by chymase.

HY-130176

UFP-512	Activator
UFP-512 is a selective and potent σ-opioid receptor (DOP receptor) peptidic agonist with antidepressant- and anxiolytic-like effects. UFP-512 exhibits as a potent agonist on adenylyl cyclase inhibition and Erk1/2 activation. UFP-512 induces phosphorylation of DOP receptors on Ser³⁶³ with a low desensitization of the cAMP pathway. UFP-512 is promising for research of mood disorders.

HY-P5440

ERKtide
ERKtide is a biological active peptide. (ERKtide is a peptide substrate for ERK2. Extracellular regulated protein kinase 2 (ERK2) is a eukaryotic protein kinase whose activity is regulated by mitogenic stimuli.)

HY-W838814

ERK1/2 inhibitor 12	Inhibitor
ERK1/2 inhibitor 12 (compound 76.3) is a ERK1/2 inhibitor which inhibits ERK-mediated phosphorylation of caspase-9 and the p90Rsk-1 kinase. ERK1/2 inhibitor 12 exhibits anti-cancer activity and can be utilized in cancer research.

HY-N3775

Dodoviscin I	Inhibitor
Dodoviscin I (Dodoviscin A) is an adipogenic agent that increases triglyceride content in 3T3L1 mouse fibroblasts. Dodoviscin I inhibits ERK2 with an IC₅₀ of 10.79 μM.

HY-168171

ERK1/2 inhibitor 11	Inhibitor
ERK1/2 inhibitor 11 (compound L6) is a dual inhibitor of ERK1/2, lending to DSB accumulation and ERK1/2 expression degradation. ERK1/2 inhibitor 11 lowers the levels of BCL-2, and induces DNA damage by inhibiting PARP and ERK1/2. ERK1/2 inhibitor 11 activates caspase 3 to inducing apoptosis..

HY-116504

WB-308	Inhibitor
WB-308 is a novel small molecule that was identified as an inhibitor of EGFR by an in vitro EGFR kinase activity system. WB-308 was able to reduce the proliferation and clonogenicity of NSCLC cells, causing G2/M phase arrest and apoptosis. In addition, WB-308 inhibited tumor growth in two in vivo animal models (lung orthotopic transplantation model and patient-derived clonal mouse model). WB-308 impaired the phosphorylation of EGFR, AKT, and ERK1/2 proteins. Compared with Gefitinib, WB-308 had lower cytotoxicity. This study showed that WB-308 is a new EGFR-TKI that may be considered as an alternative to Gefitinib in the clinical treatment of NSCLC.

HY-N7830

7α,15-Dihydroxydehydroabietic acid	Inhibitor
7α,15-Dihydroxydehydroabietic acid is a natural abietane-type diterpenoid with antiangiogenic effects.

HY-N2312R

Mogrol (Standard)	Inhibitor
Mogrol (Standard) is the analytical standard of Mogrol. This product is intended for research and analytical applications. Mogrol is a biometabolite of mogrosides, and acts via inhibition of the ERK1/2 and STAT3 pathways, or reducing CREB activation and activating AMPK signaling.

HY-112469

ERK Inhibitor II (Negative control)	Inhibitor
ERK Inhibitor II (Negative control) is an effective inhibitor of extracellular signal-regulated kinase (ERK). ERK Inhibitor II (Negative control) inhibits the activation of insulin receptor, which can be used in the study of diabetes.

HY-N11262

Sudachitin	Inhibitor
Sudachitin, a polymethoxyflavone that can be isolated from Citrus sudachi, suppresses lipopolysaccharide-induced inflammatory responses in mouse macrophage-like RAW264 cells. Sudachitin can activate the p38MAPK pathway and inhibit the ERK1/2 pathway in HaCaT cells.

HY-RS08112

Mapk15 Rat Pre-designed siRNA Set A	Inhibitor
Mapk15 Rat Pre-designed siRNA Set A contains three designed siRNAs for Mapk15 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-19696S1

Tauroursodeoxycholate-d₄	Inhibitor
Tauroursodeoxycholate-d₄ is deuterium labeled Tauroursodeoxycholate. Tauroursodeoxycholate (Tauroursodeoxycholic acid) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.

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