2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Endonuclease

Endonuclease

 
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-116770
    PFM01
    		Inhibitor 99.68%
    PFM01, N-alkylated Mirin derivative, is a MRE11 endonuclease inhibitor. PFM01 can regulate double-strand break repair (DSBR) by nonhomologous end-joining (NHEJ) versus homologous recombination (HR).
    PFM01
  • HY-145758
    FEN1-IN-SC13
    		Inhibitor 98.21%
    FEN1-IN-SC13 is a potent DNA fragmentation endonuclease 1 (FEN1) inhibitor with antitumor activity. FEN1-IN-SC13 interferes with DNA replication and repair in vitro and in cells.
    FEN1-IN-SC13
  • HY-120951
    PFM39
    		Inhibitor 99.01%
    PFM39, a Mirin analog, is a potent and selective MRE11 exonuclease inhibitor. PFM39 inhibits phosphate rotation for dsDNA exonuclease activity. PFM39 does not inhibit TmMre11 or human MRE11/MRN endonuclease activity.
    PFM39
  • HY-P2863
    Deoxyribonuclease II
    		Inhibitor
    Deoxyribonuclease II (DNase II) is an endonuclease that hydrolyzes the phosphodiester bonds of deoxyribonucleotides in native and denatured DNA, producing 3' phosphate and 5'-hydroxyl termini. Deoxyribonuclease II works best at acidic pH and is commonly used in biochemical research.
    Deoxyribonuclease II
  • HY-148078
    PFM03
    		Inhibitor 98.04%
    PFM03 is a MRE11 Endonuclease inhibitor. PFM03 regulates DNA double-strand break repair (DSBR) by nonhomologous end-joining (NHEJ).
    PFM03
  • HY-108882A
    Recombinant DNase I (RNase-free)
    Recombinant DNase I (RNase-free) is a recombinant deoxyribonuclease that degrades DNA. Recombinant DNase I is essential for limiting inflammatory responses and maintaining homeostasis.
    Recombinant DNase I (RNase-free)
  • HY-163699
    MUS81-IN-1
    		Inhibitor 99.42%
    MUS81-IN-1 (compound 23) is a MUS81 inhibitor. MUS81-IN-1 can be used in cancer research.
    MUS81-IN-1
  • HY-108860
    Oncaspar
    Oncaspar (PEG-L-asparaginase; Pegasparaginase), a pegylated form of native Escherichia coli-derived L-asparaginase, breaks down the amino acid asparagine that are circulating in the bloodstream. Oncaspar plays an important role in acute lymphoblastic leukemia (ALL).
    Oncaspar
  • HY-108858
    Dornase alfa
    Dornase alfa (rhDNase) is a recombinant human deoxyribonuclease I (rhDNase), an enzyme which selectively cleaves DNA. Dornase alfa hydrolyzes the DNA present in sputum/mucus and reduces viscosity in the lungs, promoting improved clearance of secretions. Dornase alfa plays an important role in cystic fibrosis.
    Dornase alfa
  • HY-137721
    Cyclic tri-AMP
    		Activator
    Cyclic tri-AMP is a component of the cyclic oligonucleotide-based anti-phage signaling system (CBASS), and acts as the second messenger in the immune response against viral infection. Cyclic tri-AMP binds to and activates DNA endonuclease NucC, results in cell death and exhibits antiviral activity.
    Cyclic tri-AMP
  • HY-157329
    AD16
    		Inhibitor
    AD16 (Acetamide) is a LINE-1 retrotransposon endonuclease inhibitor with the IC50 of 4.7 μM. AD16 (Acetamide) reduce LINE-1 retrotransposition, L1-induced DNA damage, and inflammation reinforced by L1 in senescent cells.
    AD16
  • HY-E70381
    dsDNase
    dsDNase is a highly specific double-strand DNA (dsDNA) endonuclease that quickly and efficiently removes contaminating DNA from PCR master mixes.
    dsDNase
  • HY-146125
    CGCG/CGG ligand 1
    		Inhibitor
    CGCG/CGG ligand 1 (compound 10), an anthracenone derivative, is a CGCG or CGG short spacer-ligand. CGCG/CGG ligand 1 can protect cleavable sites of DNA with the multiple CGCG or continuous CGG sites from the restriction enzyme.
    CGCG/CGG ligand 1
Cat. No. Product Name / Synonyms Application Reactivity