Enteropeptidase

Enterokinase; Transmembrane serine protease 15; TMPRSS15

Enteropeptidase is an enzyme produced by duodenal cells, which is involved in the digestive processes of humans and other animals and belongs to the serine protease family. Enteropeptidase can specifically cleave trypsinogen, converting it into active trypsin and initiating the protein digestion process. Enteropeptidase can also trigger a digestive enzyme cascade reaction, and the activated trypsin can further activate other digestive enzymes such as chymotrypsinogen. Enteropeptidase plays a crucial role in maintaining the homeostasis of the intestinal environment and ensuring the digestion and absorption of nutrients in the intestine. The deficiency, changes in expression and activity of enteropeptidase can lead to intestinal digestion disorders, exacerbate the inflammatory response in intestinal inflammatory diseases, and promote the proliferation and metastasis of tumor cells in colorectal cancer and other cancers^[1].

References:

[1]. Zheng XL, et al. Enteropeptidase, a type II transmembrane serine protease. Front Biosci (Elite Ed). 2009 Jun 1;1(1):242-9. [Content Brief]

Enteropeptidase Inhibitors (6)

Enteropeptidase Related Products (7):

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-P2660

Gly-Asp-Asp-Asp-Asp-Lys-β-naphthylamide		99.09%
Gly-Asp-Asp-Asp-Asp-Lys-β-naphthylamide (GD4K-na) is a substrate for human enteropeptidase (K_m: 0.16 mM).

HY-132841A

Sucunamostat hydrochloride	Inhibitor	98.14%
Sucunamostat (SCO-792) hydrochloride is an orally active and reversible enteropeptidase inhibitor with IC₅₀s of 4.6 nM and 5.4 nM for rat enteropeptidase and human enteropeptidase, respectively. Sucunamostat hydrochloride can slowly dissociate from enteropeptidase in vitro and inhibit protein digestion in vivo.

HY-130126

Sucunamostat hydrate	Inhibitor
Sucunamostat hydrate (SCO-792) is an orally active and reversible enteropeptidase inhibitor with IC₅₀s of 4.6 nM and 5.4 nM for rat enteropeptidase and human enteropeptidase, respectively. Sucunamostat hydrate can slowly dissociate from enteropeptidase in vitro and inhibit protein digestion in vivo.

HY-132841

Sucunamostat	Inhibitor
Sucunamostat (SCO-792 free acid) is an L-aspartic acid enteropeptidase inhibitor.

HY-147931

Human enteropeptidase-IN-2	Inhibitor
Human enteropeptidase-IN-2 (compound 1c) is a highly potent enteropeptidase inhibitor. Human enteropeptidase-IN-2 can be used for anti-obesity research.

HY-147927

Human enteropeptidase-IN-1	Inhibitor
Human enteropeptidase-IN-1 (compound 6b) is a highly potent, orally active and low systemic exposure enteropeptidase inhibitor. Human enteropeptidase-IN-1 boosts the increase in fecal protein output, and exhibits potent body weight loss in diet-induced obese (DIO) rat model. Human enteropeptidase-IN-1 can be used for anti-obesity research.

HY-149516

Human enteropeptidase-IN-3	Inhibitor
Human enteropeptidase-IN-3 is an enteropeptidase inhibitor. Human enteropeptidase-IN-3 exhibits enteropeptidase activity and long duration of inhibitory state. Human enteropeptidase-IN-3 can be used for intetinal digestive related diseases research.

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