2. Metabolic Enzyme/Protease
  3. Enteropeptidase
  4. Sucunamostat hydrochloride

Sucunamostat hydrochloride  (Synonyms: SCO-792 hydrochloride)

Cat. No.: HY-132841A Purity: 98.40%
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Sucunamostat (SCO-792) hydrochloride is an orally active and reversible enteropeptidase inhibitor with IC50s of 4.6 nM and 5.4 nM for rat enteropeptidase and human enteropeptidase, respectively. Sucunamostat hydrochloride can slowly dissociate from enteropeptidase in vitro and inhibit protein digestion in vivo.

For research use only. We do not sell to patients.

Sucunamostat hydrochloride Chemical Structure

Sucunamostat hydrochloride Chemical Structure

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5 mg USD 670 In-stock
10 mg USD 1070 In-stock
25 mg USD 2150 In-stock
50 mg USD 3450 In-stock
100 mg USD 5500 In-stock
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Based on 1 publication(s) in Google Scholar

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Sucunamostat hydrochloride Related Antibodies

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Description

Sucunamostat (SCO-792) hydrochloride is an orally active and reversible enteropeptidase inhibitor with IC50s of 4.6 nM and 5.4 nM for rat enteropeptidase and human enteropeptidase, respectively. Sucunamostat hydrochloride can slowly dissociate from enteropeptidase in vitro and inhibit protein digestion in vivo[1].

IC50 & Target

IC50: 4.6 nM (rat enteropeptidase), 5.4 nM (human enteropeptidase)[1]
In Vivo

Sucunamostat hydrochloride (10 and 30 mg/kg; PO, single dosage) effectively and dose-dependently inhibits plasma branched-chain amino acids (BCAA) elevations induced by oral protein dosing in rats[1].
Pharmacokinetic Parameters of Sucunamostat hydrochloride in male Sprague-Dawley rats[1]

PO (10 mg/kg) IV (2 mg/kg)
Cmax (ng/mL) 6.60 ± 1.36 564 ± 58
Tmax (h) 1.7 ± 0.6
AUC0-24 (ng/mL·h) 54.1 ± 7.5 303 ± 23
AUCinf (ng/mL·h) 49.8 ± 5.4 304 ± 30
VdSS (mL/kg) 1290 ± 299
CLp (mL/min/kg) 663 ± 66
bioavailability (%) 0.4

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

506.89

Formula

C22H23ClN4O8
Appearance

Solid

Color

White to off-white

SMILES

[H]Cl.OC(C[C@@H](C(O)=O)NC(C[C@H]1C2=CC=C(OC(C3=CC=C(C=C3)NC(N)=N)=O)C=C2OC1)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 125 mg/mL (246.60 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9728 mL 9.8641 mL 19.7281 mL
5 mM 0.3946 mL 1.9728 mL 3.9456 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9728 mL 9.8641 mL 19.7281 mL 49.3204 mL
5 mM 0.3946 mL 1.9728 mL 3.9456 mL 9.8641 mL
10 mM 0.1973 mL 0.9864 mL 1.9728 mL 4.9320 mL
15 mM 0.1315 mL 0.6576 mL 1.3152 mL 3.2880 mL
20 mM 0.0986 mL 0.4932 mL 0.9864 mL 2.4660 mL
25 mM 0.0789 mL 0.3946 mL 0.7891 mL 1.9728 mL
30 mM 0.0658 mL 0.3288 mL 0.6576 mL 1.6440 mL
40 mM 0.0493 mL 0.2466 mL 0.4932 mL 1.2330 mL
50 mM 0.0395 mL 0.1973 mL 0.3946 mL 0.9864 mL
60 mM 0.0329 mL 0.1644 mL 0.3288 mL 0.8220 mL
80 mM 0.0247 mL 0.1233 mL 0.2466 mL 0.6165 mL
100 mM 0.0197 mL 0.0986 mL 0.1973 mL 0.4932 mL
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Sucunamostat hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SucunamostatSCO-792SCO792SCO 792EnteropeptidaseEnterokinaseTransmembrane serine protease 15TMPRSS15Inhibitorinhibitorinhibit

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