Ferroptosis

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Ferroptosis is a non-apoptotic form of regulated cell death. It is distinct from other regulated cell death phenotypes, such as apoptosis and necroptosis. Ferroptosis is characterized by extensive lipid peroxidation, which can be suppressed by iron chelators or lipophilic antioxidants. Mechanistically, Ferroptosis inducers are divided into two classes: (1) inhibitors of cystine import via system x_c⁻ (e.g., Erastin), which subsequently causes depletion of glutathione (GSH), and (2) covalent inhibitors (e.g., (1S, 3R)-RSL3) of glutathione peroxidase 4 (GPX4). Since GPX4 reduces lipid hydroperoxides using GSH as a co-substrate, both compound classes ultimately result in loss of GPX4 activity, followed by elevated levels of lipid reactive oxygen species (ROS) and consequent cell death.

Ferroptosis is an iron- and ROS-dependent form of regulated cell death (RCD). Misregulated Ferroptosis has been implicated in multiple physiological and pathological processes, including cancer cell death, neurotoxicity, neurodegenerative diseases, acute renal failure, drug-induced hepatotoxicity, hepatic and heart ischemia/reperfusion injury, and T-cell immunity.

Ferroptosis Related Products (394)
Antibodies (5)
Ferroptosis Signaling Pathway

By Effects:	Inhibitors (167) Activators (121) Inducers (74)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-N0193

Artesunate	Activator	98.09%
Artesunate is an inhibitor of both STAT-3 and exported protein 1 (EXP1).

HY-106376A

L-Buthionine-(S,R)-sulfoximine	Activator	99.94%
L-Buthionine-(S,R)-sulfoximine is a cell-permeable, potent, fast acting and irreversible inhibitor of g-glutamylcysteine synthetase and depletes cellular glutathione levels. The IC₅₀ value of L-Buthionine-(S,R)-sulfoximine on melanoma, breast and ovarian tumor specimens are 1.9 μM, 8.6 μM, and 29 μM, respectively.

HY-100003

ML-210	Activator	99.89%
ML-210 is a selective and covalent glutathione peroxidase 4 (GPX4) inhibitor with an EC₅₀ of 30 nM. ML-210 binds the GPX4 selenocysteine residue. ML-210 has anti-cancer activity.

HY-B0451A

Dopamine hydrochloride	Inhibitor	99.61%
Dopamine hydrochloride (ASL279) is a catecholamine neurotransmitter that is produced in the substantia nigra, ventral tegmental area, and hypothalamus of the brain. Dopamine hydrochloride (ASL279) plays several important roles in the brain and body. Dopamine hydrochloride (ASL279) acts through D2 dopamine receptors to induce endocytosis of VEGFR2/KDR/Flk-1, which is critical for promoting angiogenesis.

HY-50935

Troglitazone	Inhibitor	99.78%
Troglitazone is an orally active PPARγ agonist, with EC₅₀s of 550 nM and 780 nM for human and murine PPARγ receptor, respectively. Troglitazone has anticancer activity, prevents and inhibits the development of type 2 diabetes.

HY-N0111

Coenzyme Q10	Inhibitor	99.69%
Coenzyme Q10 is an essential cofactor of the electron transport chain and a potent antioxidant agent.

HY-19980

Eprenetapopt	Activator	≥98.0%
Eprenetapopt (APR-246) is a first-in-class, small molecule that restores wild-type p53 functions in TP53-mutant cells. Eprenetapopt triggers apoptosis in tumor cells. Eprenetapopt also targets the selenoprotein thioredoxin reductase 1 (TrxR1), a key regulator of cellular redox balance.

HY-N0523

Gallic acid	Activator	99.98%
Gallic acid (3,4,5-Trihydroxybenzoic acid) is a natural polyhydroxyphenolic compound and an free radical scavenger to inhibit cyclooxygenase-2 (COX-2). Gallic acid has various activities, such as antimicrobial, antioxidant, antimicrobial, anti-inflammatory, and anticance activities.

HY-100002

ML162	Activator	99.45%
ML162 is a covalent glutathione peroxidase 4 (GPX4) inhibitor. ML162 has a selective lethal effect on mutant RAS oncogene-expressing cell lines

HY-106376

DL-Buthionine-(S,R)-sulfoximine	Activator	99.67%
DL-Buthionine-(S,R)-sulfoximine is a potent inhibitor of glutamylcysteine synthetase biosynthesis.

HY-B0094

Artemisinin	Activator	≥98.0%
Artemisinin (Qinghaosu), a sesquiterpene lactone, is an anti-malarial agent isolated from the aerial parts of Artemisia annua L. plants. Artemisinin inhibits AKT signaling pathway by decreasing pAKT in a dose-dependent manner. Artemisinin reduces cancer cell proliferation, migration, invasion, tumorigenesis and metastasis and has neuroprotective effects.

HY-10201A

Sorafenib Tosylate	Activator	99.91%
Sorafenib Tosylate (Bay 43-9006 Tosylate) is a potent and orally active Raf inhibitor with IC₅₀s of 6 nM and 20 nM for Raf-1 and B-Raf, respectively. SorafenibTosylate is a multikinase inhibitor with IC₅₀s of 90 nM, 15 nM, 20 nM, 57 nM and 58 nM for VEGFR2/KDR/Flk-1, VEGFR3/Flt-4, PDGFRβ, FLT3 and c-Kit, respectively. Sorafenib Tosylate induces autophagy and apoptosis. Sorafenib Tosylate has anti-tumor activity. Sorafenib Tosylate is a ferroptosis activator.

HY-114481

Imidazole ketone erastin	Inducer	99.83%
Imidazole ketone erastin is a potent, selective, and metabolically stable inhibitor of the cystine-glutamate antiporter, system x_c^- and an activator of ferroptosis. Imidazole ketone erastin has anti-tumor activity.

HY-10257

BAY 11-7085	Activator	99.99%
BAY 11-7085 (BAY 11-7083) is an inhibitor of NF-κB activation and phosphorylation of IκBα; it stabilizes IκBα with an IC₅₀ of 10 μM.

HY-N2329

Piperlongumine	Activator	99.87%
Piperlongumine is a alkaloid, possesses ant-inflammatory, antibacterial, antiangiogenic, antioxidant, antitumor, and antidiabetic activities. Piperlongumine induces ROS, and induces apoptosis in cancer cell lines. Piperlongumine shows anti-cardiac fibrosis activity, suppresses myofibroblast transformation via suppression of the ERK1/2 signaling pathway. Piperlongumin could be used in the study of migrasome.

HY-12298

Setanaxib	Inhibitor	99.45%
Setanaxib (GKT137831) is a selective NADPH oxidase (NOX1/4) inhibitor with K_is of 140 and 110 nM, respectively.

HY-14164

Zileuton	Inhibitor	99.86%
Zileuton is a potent and selective inhibitor of 5-lipoxygenase with antiasthmatic properties.

HY-15836

BAY 87-2243	Activator	99.41%
BAY 87-2243 is a highly potent and selective hypoxia-inducible factor-1 (HIF-1) inhibitor.

HY-17359

Deferasirox	Inhibitor	99.65%
Deferasirox (ICL 670) is an orally available iron chelator used for the management of transfusional iron overload.

HY-Y0520

Itaconic acid	Inducer	99.98%
Itaconic acid, a precursor of polymers, chemicals, and fuels, can be synthesized by many fungi. Itaconic acid also is a macrophage-specific metabolite. Itaconic acid mediates crosstalk between macrophage metabolism and peritoneal tumors. Itaconic acid has anti-inflammatory, anti-microbial and immunomodulatory effect.

Cystine NOX1 DPP4 Glutamine Tf Methionine Homocysteine p53 CBS Cystathionine Cystine CTH GCLC ABCA1 SREBP2 G6PD γ-glutamylcysteine GSS Ac-CoA HMG-CoA HMGCR Mevalonate Isopentenyl-PP Farnesyl-PP Squalene Squalene-2,3-epoxide Cholesterol FDFT1 SQLE AIFM2 NADPH GSH CDKN1A Se GPX4 Se p21 p53 NRF2 KEAP1 p62 CoQ10 PRDX CHMP5 AKR1Cs CHMP6 ESCRT-Ⅲ Lipid ROS PRDX PRDX GLS2 Glutamine VDAC2/3 GOT1 αKG Fumarate Succinate OXPHOS Citrate Malate ROS ACL Ac-CoA NCOA4 Ferritinophagy Iron Import FTH1 FTL Storage Endosome STEAPs ACACA RAB7A FASN Mal-CoA Fatty Acid Lipophagy Lible iron pool Ferritinophagy STEAP3 NCOA4 Ferritin LDs Storage AA/AdA Ferroptocide TXN PRDX ROS ACSL4 AA/AdA-CoA LPCAT3 AA/AdA-PE TPD52 CAV1 TXN POR ALOXs HMOX1 Heme Fenton
reaction ROS PEX10 PEX3 PUFA-plasmalogen Peroxisome Lysosome CTSB DNA damage/H3 cleavage Membrane oxidative damage Ferroptosis RNS p53 BAP1

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Ferroptosis

Ferroptosis

Ferroptosis Related Products (394)

Antibodies (5)

Ferroptosis Signaling Pathway

Ferroptosis Related Products (394):