2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Furin

Furin

Furin

Furin belongs to the proprotein convertase (PC) family. Furin is able to recognize specific amino acid sequences and cleave the protein precursors at these sequences, thereby converting inactive precursor proteins into mature proteins with functional activity. Furin is involved in the processing and maturation of intracellular proteins, such as coagulation factor Ⅷ and angiotensinogen. By cleaving cell surface receptors and signaling molecules, Furin participates in cell signaling transduction and regulates various vital activities of cells, such as cell proliferation, differentiation, and apoptosis. In addition, during viral infections, Furin can cleave the glycoproteins on the surface of the virus, promoting the fusion of the virus with the host cell membrane and facilitating the entry of the virus into the host cell. Furin plays an important role in a variety of diseases, including cardiovascular diseases, tumors, neurodegenerative diseases, and infectious diseases[1][2].

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-147140
    BOS-318
    		98.45%
    BOS-318 is a potent, slowly dissociating, highly selective, and cell-permeable furin inhibitor with IC50 value of 1.9 nM. BOS-318 protects ENaC from subsequent activation by neutrophil elastase. BOS-318 can be used for the rsearch for CF lung disease.
    BOS-318
  • HY-P4548
    Boc-Arg-Val-Arg-Arg-AMC hydrochloride
    		99.18%
    Boc-Arg-Val-Arg-Arg-AMC hydrochloride (Boc-RVRR-AMC) is a synthetic fluorogenic substrate that is efficiently cleaved by furin.
    Boc-Arg-Val-Arg-Arg-AMC hydrochloride
  • HY-P5062A
    DEC-RVRK-CMK TFA
    		Inhibitor
    DEC-RVRK-CMK (Decanoyl-Arg-Val-Arg-Lys-chloromethylketone) TFA is a peptide-based CMK (chloromethylketone) inhibitor that targets and inactivates the secreted soluble kexin (Kex2) (Ki=8.45 μM). The yeast enzyme Kex2 (kexin, EC 3.4.21.61) is a calcium-dependent transmembrane protease and belongs to the mammalian protease family of the serine protease subtilisin family. The binding mechanism of Kex2 with different CMK inhibitors depends on substrate selectivity, particularly the selective differences between lysine and arginine at the P1 position.
    DEC-RVRK-CMK TFA
  • HY-110147B
    SSM3 tetraTFA hydrate
    		≥99.0%
    SSM3 tetraTFA hydrate is a potent synthetic furin inhibitor with an EC50 and a Ki of 54 nM and 12 nM, respectively. SSM3 tetraTFA hydrate is able to block furin-dependent cell surface processing of anthrax protective antigen-83 in vitro.
    SSM3 tetraTFA hydrate
  • HY-P5062
    DEC-RVRK-CMK
    		Inhibitor
    DEC-RVRK-CMK (Decanoyl-Arg-Val-Arg-Lys-chloromethylketone) is a peptide-based CMK (chloromethylketone) inhibitor that targets and inactivates the secreted soluble kexin (Kex2) (Ki=8.45 μM). The yeast enzyme Kex2 (kexin, EC 3.4.21.61) is a calcium-dependent transmembrane protease and belongs to the mammalian protease family of the serine protease subtilisin family. The binding mechanism of Kex2 with different CMK inhibitors depends on substrate selectivity, particularly the selective differences between lysine and arginine at the P1 position.
    DEC-RVRK-CMK
  • HY-110147A
    SSM3 tetraTFA
    SSM3 tetraTFA is a potent synthetic furin inhibitor with an EC50 and a Ki of 54 nM and 12 nM, respectively. SSM3 tetraTFA is able to block furin-dependent cell surface processing of anthrax protective antigen-83 in vitro.
    SSM3 tetraTFA
  • HY-P3797
    Furin Substrate
    Furin Substrate is an peptide. Furin Substrate can be used for the research of various biochemical.
    Furin Substrate
  • HY-163738
    Furin-IN-2
    		Inhibitor
    Furin-IN-2 (compound P3) is a potent inhibitor of furin, with the IC50 of 35 μM. Furin-IN-2 shows antiviral activity.
    Furin-IN-2
Cat. No. Product Name / Synonyms Application Reactivity