2. Metabolic Enzyme/Protease
  3. Furin
  4. SSM3 tetraTFA hydrate

SSM3 tetraTFA hydrate is a potent synthetic furin inhibitor with an EC50 and a Ki of 54 nM and 12 nM, respectively. SSM3 tetraTFA hydrate is able to block furin-dependent cell surface processing of anthrax protective antigen-83 in vitro.

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SSM3 tetraTFA hydrate Chemical Structure

SSM3 tetraTFA hydrate Chemical Structure

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Based on 1 publication(s) in Google Scholar

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SSM3 tetraTFA hydrate Related Antibodies

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Description

SSM3 tetraTFA hydrate is a potent synthetic furin inhibitor with an EC50 and a Ki of 54 nM and 12 nM, respectively. SSM3 tetraTFA hydrate is able to block furin-dependent cell surface processing of anthrax protective antigen-83 in vitro[1][2].

IC50 & Target

EC50: 54 nM (furin)
Ki: 12 nM (furin)[1]
In Vitro

SSM3 tetraTFA hydrate is against furin cleavage of the Pyr-RTKR-AMC substrate with an EC50 of 54 nM in vitro cleavage assays and cell-based tests[2].
SSM3 tetraTFA hydrate (0.1-25 μM) inhibits the furin-dependent conversion of PA83 into PA63 in a dose dependent manner, it inhibits PA83 processing in the cleavage reactions[2].
SSM3 tetraTFA hydrate shows comparable potency against furin (Ki=0.012 μM) and PC6B (Ki=0.004 μM), these compounds preferentially inhibited furin over PACE4 (Ki=0.041 μM) by 2- to 10-fold and over PC7 (Ki=0.595 μM) by 11- to 76-fold. In addition, it inhibits LF (Ki=1.241 μM) 25- to 167-fold less effectively than in furin and shows no measurable inhibition against trypsin and MT1-MMP[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SSM3 tetraTFA hydrate Related Antibodies
Molecular Weight

979.70

Formula

C30H36F12N12O10.1.5H2O
Appearance

Solid

Color

White to off-white

SMILES

N=C(N)NC(C=C1)=CC=C1O[C@@H]2[C@H](C[C@@H](NC(N)=N)[C@H](OC3=CC=C(NC(N)=N)C=C3)C2)NC(N)=N.OC(C(F)(F)F)=O.OC(C(F)(F)F)=O.OC(C(F)(F)F)=O.OC(C(F)(F)F)=O.O.[1.5]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 30 mg/mL (30.62 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0207 mL 5.1036 mL 10.2072 mL
5 mM 0.2041 mL 1.0207 mL 2.0414 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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In Vivo Dissolution Calculator
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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.0207 mL 5.1036 mL 10.2072 mL 25.5180 mL
5 mM 0.2041 mL 1.0207 mL 2.0414 mL 5.1036 mL
10 mM 0.1021 mL 0.5104 mL 1.0207 mL 2.5518 mL
15 mM 0.0680 mL 0.3402 mL 0.6805 mL 1.7012 mL
20 mM 0.0510 mL 0.2552 mL 0.5104 mL 1.2759 mL
25 mM 0.0408 mL 0.2041 mL 0.4083 mL 1.0207 mL
30 mM 0.0340 mL 0.1701 mL 0.3402 mL 0.8506 mL
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SSM3 tetraTFA hydrate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SSM3 tetraTFAFurinfibrosarcomaHT1080gliomaU251breastcarcinomaMCF7cellsfurinInhibitorinhibitorinhibit

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