GGTase

Geranylgeranyl Transferase

GGTase belongs to the family of isoprenyltransferases. It can transfer the geranylgeranyl group of GGPP to the cysteine residues of specific proteins. This post-translational modification can change the properties and functions of proteins, affecting their intracellular localization, stability, and interactions with other molecules, etc. GGTase is involved in cell signal transduction. By geranylgeranylating small G proteins, it can activate downstream signaling pathways, thus regulating processes such as cell proliferation and differentiation. In addition, GGTase is also involved in vesicle transport and the regulation of the cytoskeleton organization, which can alter cell morphology and migration ability. Abnormalities in its function or changes in its expression are closely related to tumors, neurodegenerative diseases, and cardiovascular diseases^[1]^[2].

References:

[1]. Marchwicka A, et al. Protein Prenyltransferases and Their Inhibitors: Structural and Functional Characterization. Int J Mol Sci. 2022 May 12;23(10):5424. [Content Brief]

[2]. Sjogren AK, et al. GGTase-I deficiency reduces tumor formation and improves survival in mice with K-RAS-induced lung cancer. J Clin Invest. 2007 May;117(5):1294-304. [Content Brief]

GGTase Inhibitor (1)

GGTase Related Products (1):

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-16229A

GGTI-2154 hydrochloride	Inhibitor	98.93%
GGTI-2154 hydrochloride is a potent and selective inhibitor geranylgeranyltransferase I (GGTase I), with an IC₅₀ of 21 nM. GGTI-2154 hydrochloride shows more than 200-fold selectivity for GGTase I over FTase (IC50=5600 nM). GGTI-2154 hydrochloride can be used for the research of cancer.

Name
Email *

	Sorry, but the email address you supplied was invalid.