1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. GGTase

GGTase

Geranylgeranyl Transferase

GGTase belongs to the family of isoprenyltransferases. It can transfer the geranylgeranyl group of GGPP to the cysteine residues of specific proteins. This post-translational modification can change the properties and functions of proteins, affecting their intracellular localization, stability, and interactions with other molecules, etc. GGTase is involved in cell signal transduction. By geranylgeranylating small G proteins, it can activate downstream signaling pathways, thus regulating processes such as cell proliferation and differentiation. In addition, GGTase is also involved in vesicle transport and the regulation of the cytoskeleton organization, which can alter cell morphology and migration ability. Abnormalities in its function or changes in its expression are closely related to tumors, neurodegenerative diseases, and cardiovascular diseases[1][2].

GGTase Related Products (1):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-16229A
    GGTI-2154 hydrochloride
    Inhibitor 98.93%
    GGTI-2154 hydrochloride is a potent and selective inhibitor geranylgeranyltransferase I (GGTase I), with an IC50 of 21 nM. GGTI-2154 hydrochloride shows more than 200-fold selectivity for GGTase I over FTase (IC50=5600 nM). GGTI-2154 hydrochloride can be used for the research of cancer.
    GGTI-2154 hydrochloride