2. Signaling Pathways
  3. GPCR/G Protein
  4. GnRH Receptor

GnRH Receptor

Gonadotropin releasing hormone receptor; GNRHR

GnRH Receptor

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The GnRH receptor (Gonadotropin-releasing hormone receptor, GNRHR) is a member of the rhodopsin-like G protein-coupled receptor (GPCR) family and consists of seven transmembrane helical domains connected via extra- and intra-cellular segments. GnRH receptor is located on the plasma membrane of gonadotrophs, pituitary cells that synthesize the gonadotrophins LH and FSH.

Mammalian type I and II GnRH receptors show differential ligand preference for GnRH-I (also named as LHRHR) and GnRH-II, respectively. All GnRH receptors activate the Gq/11 family of G proteins, which activate phospholipase C-catalyzed production of second messengers that activate protein kinase C (PKC). GnRH receptor activated by GnRH analogues stimulates the synthesis and release of LH and FSH. GnRH receptors can be used for the research of breast and prostate cancer, regulation of fertility, endometriosis and a range of other medical and veterinary uses.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P3664
    [D-Phe2,D-Ala6]-LH-RH
    [D-Phe2,D-Ala6]-LH-RH is a potent LH-RH antagonist. [D-Phe2,D-Ala6]-LH-RH shows anti-LH/FSH-RH and antiovulatory activities.
    [D-Phe2,D-Ala6]-LH-RH
  • HY-P3641
    Kisspeptin 13
    		Activator
    Kisspeptin 13 inhibits glucose-induced insulin secretion with an IC50 of 1.2 nM. Kisspeptin 13 activates the hypothalamic-pituitary-adrenal (HPA) axis, causes hyperthermia, motor behavior and anxiety in rats. Kisspeptin 13 interacts with α2-adrenergic and 5-HT2 serotonin receptors, exhibits antidepressant efficacy. Kisspeptin 13 is an activator for GPR54 and GnRH receptor, which enhances memory and can be used in Alzheimer's disease research.
    Kisspeptin 13
  • HY-P3670
    [D-Leu6, Val7]-LH-RH (1-9) Ethyl Amide
    [D-Leu6, Val7]-LH-RH (1-9) Ethyl Amide is a LHRH peptide analogue.
    [D-Leu6, Val7]-LH-RH (1-9) Ethyl Amide
  • HY-P4432
    (Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH (salmon)
    		Activator
    (Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH (salmon) is a GnRH analog that induces ovulation and/or spawning in farmed fish.
    (Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH (salmon)
  • HY-P4463
    (Des-Pyr1)-LHRH
    (Des-Pyr1)-LHRH is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development.
    (Des-Pyr1)-LHRH
  • HY-P4447
    (Des-Gly10,D-Pyr1,D-Leu6,Pro-NHEt9)-LHRH
    (Des-Gly10,D-Pyr1,D-Leu6,Pro-NHEt9)-LHRH is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development.
    (Des-Gly10,D-Pyr1,D-Leu6,Pro-NHEt9)-LHRH
  • HY-P3672
    [D-Ala6]-LH-RH
    		Agonist
    [D-Ala6]-LH-RH is a Luteinizing-hormone-releasing hormone (LHRH) analogue. [D-Ala6]-LH-RH acts as a GnRH receptor agonist.
    [D-Ala6]-LH-RH
  • HY-16474S
    Relugolix-d6
    		Antagonist
    Relugolix-d6 is deuterium labeled Relugolix. Relugolix (TAK-385) is a potent, orally active, nonpeptidic gonadotropin-releasing hormone (GnRH) antagonist. Relugolix possesses high affinity and potent antagonistic activity for human receptor (binding IC50=0.33 nM) and monkey receptor (IC50=0.32 nM) compared with TAK-013 (HY-100209)[1]. Relugolix is used for the study of sex-hormone-dependent diseases, such as including endometriosis, uterine fibroids and prostate cancer et al[2].
    Relugolix-d<sub>6</sub>
  • HY-P3946
    Prolactin-Releasing Peptide (1-31), bovine
    Prolactin-Releasing Peptide (1-31), bovine is a fragment of the prolactin releasing peptide (PrRP).
    Prolactin-Releasing Peptide (1-31), bovine
  • HY-P4440
    (Des-Gly10,Des-Ser4,D-Leu6,Pro-NHEt9)-LHRH
    (Des-Gly10,Des-Ser4,D-Leu6,Pro-NHEt9)-LHRH is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development.
    (Des-Gly10,Des-Ser4,D-Leu6,Pro-NHEt9)-LHRH
  • HY-107850A
    5α-Pregnane-3α,20α-diol
    5α-Pregnane-3α,20α-diol (Allopregnanediol) is a derivative of progesterone and is one of the various steroids secreted by the ovaries of rats. 5α-Pregnane-3α,20α-diol can significantly stimulate the release of luteinizing hormone (LH) in castrated rats that have been pre-treated with estrogen, while simultaneously inhibiting the secretion of follicle-stimulating hormone (FSH).
    5α-Pregnane-3α,20α-diol
  • HY-P4445
    (Des-Gly10,D-Leu6,Orn8,Pro-NHEt9)-LHRH
    (Des-Gly10,D-Leu6,Orn8,Pro-NHEt9)-LHRH is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development.
    (Des-Gly10,D-Leu6,Orn8,Pro-NHEt9)-LHRH
  • HY-P1628
    Ganirelix
    		Antagonist
    Ganirelix is a competitive and selective gonadotropin releasing hormone (GnRH) antagonist. Ganirelix prevents endogenous GnRH from inducing luteinising hormone (LH) and follicle stimulating hormone relea.
    Ganirelix
  • HY-16168
    Degarelix acetate
    		Antagonist
    Degarelix acetate (FE 200486) is a decapeptide that shows high affinity/selectivity to human gonadotropin-releasing hormone (GnRH) receptor (IC50 = 3 nM). Degarelix acetate (FE 200486) is used for the research of prostate cancer.
    Degarelix acetate
  • HY-P2110
    RS-18286
    		Antagonist
    RS-18286 is a potent luteinizing-hormone (LH)-releasing hormone (LHRH) antagonist. RS-18286 blocks the pituitary LHRH receptor and suppresses pituitary luteinizing-hormone (LH) secretion and reduce serum concentrations of gonadal steroids.
    RS-18286
  • HY-P4538
    (D-Leu6,Pro-NHEt9)-LHRH (4-9)
    (D-Leu6,Pro-NHEt9)-LHRH (4-9) is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development.
    (D-Leu6,Pro-NHEt9)-LHRH (4-9)
  • HY-14369R
    Elagolix sodium (Standard)
    		Antagonist
    Elagolix sodium (Standard) is the analytical standard of Elagolix sodium. This product is intended for research and analytical applications. Elagolix sodium is a human GnRH receptor (GnRHR) antagonist with an IC50 and Ki of 0.25 and 3.7 nM, respectively.
    Elagolix sodium (Standard)
  • HY-107534
    AG-045572
    		Antagonist 99.52%
    AG-045572 is a GnRH receptor antagonist with Kis of 6.0 nM and 3.8 nM for human and rat GnRH receptor, respectively. AG-045572 is metabolized by CYP3A and ressuppresses testosterone.
    AG-045572
  • HY-17405R
    Alarelin (Acetate) (Standard)
    		Agonist
    Alarelin (Acetate) (Standard) is the analytical standard of Alarelin (Acetate). This product is intended for research and analytical applications. Alarelin acetate is a synthetic GnRH agonist.
    Alarelin (Acetate) (Standard)
  • HY-117982
    SKI2496
    		Antagonist
    SKI2496 is an orally active GnRH receptor antagonist (IC50: 0.25 nM for hGnRHR, 13.2 nM for monkey GnRHR, 279.2 nM for rat GnRHR). SKI2496 blocks Ca2+ flux with an IC50 value of 0.76 nM. SKI2496 inhibits ERK1/2 phosphorylation with an IC50 value of 2.6 nM. SKI2496 inhbits serum LH concentrations, and can be used for research of sex hormone-dependent disorders.
    SKI2496
Cat. No. Product Name / Synonyms Application Reactivity