2. Signaling Pathways
  3. GPCR/G Protein
  4. Guanylate Cyclase
  5. Guanylate Cyclase Activator

Guanylate Cyclase Activator

Guanylate Cyclase Activators (36):

Cat. No. Product Name Effect Purity
  • HY-P3769
    Prepro-ANF (56-92), human
    		Activator 99.93%
    Prepro-ANF (56-92), human is a human atrial natriuretic factor precursor. Prepro-ANF (56-92), human is also a guanylate cyclase activator that enhances particulate guanylate cyclase activity in the renal membrane and renal unit.
  • HY-P1179
    Guanylin(human)
    		Activator
    Guanylin(human), a 15-amino acid peptide, is an endogenous intestinal guanylate cyclase activator. Guanylin(human) is mainly found in gastrointestinal tract which regulates electrolytead water transport in intestinal and renal epithelia through cyclic GMP-dependent mechanism.
  • HY-U00172
    Ipramidil
    		Activator ≥98.0%
    Ipramidil (C80-1324)?是一种血管扩张剂，在离体心脏的冠脉循环中具有显着的活性扩张。Ipramidil?可引起?NO?释放增加，并刺激鸟苷酸环化酶活性。
  • HY-137446
    Mosliciguat
    		Activator
    Mosliciguat is a guanylate cyclase activator.
  • HY-117962A
    BI 703704
    		Activator
    BI 703704 is a potent soluble guanylate cyclase (sGC) activator. BI 703704 inhibits the progression of diabetic nephropathy in the ZSF1 rat.
  • HY-111516
    MGV354
    		Activator
    MGV354 is a soluble guanylate cyclase (sGC) activator with EC50s of <0.5 nM, and 5 nM in CHO and GTM-3 E cells, respectively.
  • HY-153092
    Avenciguat
    		Activator
    Avenciguat (BI-685509) is a potent and orally active sGC activator. Avenciguat restores cyclic guanosine monophosphate (cGMP) and improves functionality of nitric oxide (NO) pathways. Avenciguat can be used in research of chronic kidney disease (CKD) and diabetic kidney disease (DKD).
  • HY-117962
    (Rac)-BI 703704
    		Activator
    (Rac)-BI 703704 is a potent soluble guanylyl cyclase (sGC) activator. (Rac)-BI 703704 reduces progression of renal damage in the ZSF1 rat, and highlight the potential of sGC activation as an effective therapy for diabetic nephropathy.
  • HY-159523
    Nurandociguatum
    		Activator
    Nurandociguatum (Nurandociguat) is a guanylate cyclase activator.
  • HY-147377
    N-Salicyloyltryptamine
    		Activator
    N-Salicyloyltryptamine acts on voltage-dependent Na+, Ca2+, and K+ ion channels inhibitor. N-Salicyloyltryptamine inhibits K+ currents with an IC50 value of 34.6 μM (Ito). N-Salicyloyltryptamine also exhibits anticonvulsant, anti-inflammatory, analgesic, and vasorelaxation effect-.
  • HY-100295
    (4-Acetamidocyclohexyl) nitrate
    		Activator
    (4-Acetamidocyclohexyl) nitrate (BM121307) is a guanylate cyclase activator.
  • HY-P5077
    Guanylin (mouse, rat)
    		Activator
    Guanylin (mouse, rat), a petide, is composed of 15 amino acids. Guanylin (mouse, rat) is an activator of intestinal guanylate cyclase. Guanylin (mouse, rat) can be used for the research of diarrhea.
  • HY-14779R
    Riociguat (Standard)
    		Activator
    Riociguat (Standard) is the analytical standard of Riociguat. This product is intended for research and analytical applications. Riociguat is an oral stimulator of soluble guanylate cyclase (sGC) used in the treatment of pulmonary hypertension.
  • HY-16774R
    Vericiguat (Standard)
    		Activator
    Vericiguat (Standard) is the analytical standard of Vericiguat. This product is intended for research and analytical applications. Vericiguat (BAY1021189) is a potent, orally available and soluble guanylate cyclase stimulator.
  • HY-107548
    A-350619 hydrochloride
    		Activator
    A-350619 hydrochloride is a soluble guanylate cyclase (sGC) activator. A-350619 hydrochloride can be used in the study of erectile dysfunction.
  • HY-161681
    Formycin triphosphate
    		Activator
    Formycin triphosphate is a fluorescent analogue of ATP which on binding to enzyme active sites exhibits enhanced fluorescence. Formycin triphosphate is an ATP-competitive chicken liver pyruvate carboxylase inhibitor. Formycin triphosphate potentiates atrial natriuretic factor (ANF)-stimulated guanylate cyclase activity with an EC50 at about 90 μM and inhibits ATP-stimulated guanylate cyclase activity with an IC50 at about 100 μM.