2. Signaling Pathways
  3. Epigenetics
  4. HuR

HuR

Human Antigen R

Human Antigen R (HuR), also known as ELAV-like protein 1 (ELAVL1), is an RNA-binding protein that plays a crucial role in the process of RNA metabolism within cells. HuR enhances the stability of mRNA and guides the mRNA to be transported from the nucleus to the cytoplasm through the nuclear pore complex, ensuring that the mRNA reaches the ribosomes for translation. HuR can also interact with translation initiation factors to promote the binding of ribosomes to mRNA, thereby regulating the translation efficiency of mRNA and affecting protein synthesis. By regulating the stability, transportation, and translation of the mRNAs of related genes, HuR plays an important role in tumors, neurodegenerative diseases, and inflammatory diseases[1][2].

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-124828
    CMLD-2
    		Inhibitor 98.99%
    CMLD-2, an inhibitor of HuR-ARE interaction, competitively binds HuR protein disrupting its interaction with adenine-uridine rich elements (ARE)-containing mRNAs (Ki=350 nM). CMLD-2 induces apoptosis exhibits antitumor activity in different cancer cells as colon, pancreatic, thyroid and lung cancer cell lines. Hu antigen R (HuR) is an RNA binding protein, can regulate target mRNAs stability and translation.
    CMLD-2
  • HY-134601
    KH-3
    		Inhibitor 98.91%
    KH-3 is a potent RNA-binding protein Hu antigen R (HuR) inhibitor with an IC50 value of 0.35 μM. KH-3 has anti-proliferative activity. KH-3 suppresses breast cancer cell invasion as well as delays the initiation of lung colonies by disrupting HuR-FOXQ1 mRNA interaction.
    KH-3
  • HY-148853
    SRI-42127
    		Inhibitor 99.80%
    SRI-42127 is a HuR translocation inhibitor. HuR is an RNA regulator that binds to AREs, and HuR translocations promote the production of inflammatory cytokines in glial cells. However, SRI-42127 can destroy mRNA stability and inhibit gene promoter activation. SRI-42127 also inhibits microglial cell activation and attenuates recruitment/chemotaxis of neutrophils and monocytes.
    SRI-42127
  • HY-163759
    HuR degrader 2
    		Degrader
    HuR degrader 2 (Compound 3) is a molecule glue, which targets RNA-binding protein Hu antigen R (HuR) and degrades 30% HuR at 0.1 μM. HuR degrader 2 inhibits the proliferation of cancer cell Colo-205, with IC50≤200 nM. HuR degrader 2 exhibits a high affinity with cereblon, with an HTRF ratio < 0.02.
    HuR degrader 2
  • HY-160783
    SRI-43265
    		Inhibitor 99.08%
    SRI-43265 (compound 40) is an inhibitor of human antigen R protein (HuR) dimerization, and HuR multimers have been implicated in cancer and inflammatory pathogenesis.
    SRI-43265
  • HY-163760
    ZM-32
    		Inhibitor
    ZM-32 is an inhibitor for human antigen R (HuR), that downregulates the expression of VEGF-A and MMP9, and thus inhibits breast cancer tumor angiogenesis. ZM-32 exhibits broad-spectrum anti-proliferative effects in a variety of cancer cell lines, and exhibits antitumor efficacy against MDA-MB-231 in mouse models.
    ZM-32
  • HY-124844
    Azaphilone-9
    		Inhibitor
    Azaphilone-9 (AZA-9) is an inhibitor of HuR-ARE RNA interaction (IC50=1.2 μM) by binding RNA-binding protein Hu antigen R (HuR). The HuR-RNA interactions stabilize many oncogenic mRNAs in tumors. Thus Azaphilone-9 potentially inhibit cancer cell growth and progression.
    Azaphilone-9
  • HY-101112
    Okicenone
    		Inhibitor
    Okicenone is a Hu protein R (HuR) inhibitor. Okicenone inhibits HuR oligomerization, interferes with HuR RNA binding, HuR trafficking, cytokine expression and T-cell activation.
    Okicenone
  • HY-168539
    TM11
    		Inhibitor
    TM11, a Tanshinone mimic, is a potent HuR inhibitor that can inhibit HuR-RNA complex formation. TM11 reduces LPS-induced inflammatory response in murine macrophages.
    TM11
Cat. No. Product Name / Synonyms Application Reactivity