2. Signaling Pathways
  3. Protein Tyrosine Kinase/RTK
  4. IGF-1R
  5. IGF-1R Antagonist

IGF-1R Antagonist

IGF-1R Antagonists (3):

Cat. No. Product Name Effect Purity
  • HY-P991042
    Anti-IGFBP2 Antibody (M14)
    		Antagonist
    Anti-IGFBP2 Antibody (M14) is an human anti-IGFBP2 monoclonal inhibitory antibody, which binds IGFBP2 with high affinity and blocks its binding with IGF1. Anti-IGFBP2 Antibody (M14) inhibits human endothelial cell recruitment, thus blocks the tumor progression of human metastatic cancer.
  • HY-P99274
    Xentuzumab
    		Antagonist 99.71%
    Xentuzumab (Anti-Human IGF1 and IGF2 Recombinant Antibody; BI836845) is a recombinant a human monoclonal antibody that targets IGF ligands IGF1 and IGF2. Xentuzumab inhibits both of IGF1 and IGF2 growth-promoting signalling and suppresses AKT activation.
  • HY-P3226
    JB-1
    		Antagonist
    JB-1, an IGF-1 peptide analog, is a selective and potent IGF-1R antagonist. JB-1 competes with IGF-1 by binding the IGF-1 receptor. JB-1 prevents the autophosphorylation of IGF-1R, and has no activity in IGF-II.