2. Protein Tyrosine Kinase/RTK
  3. IGF-1R
  4. Xentuzumab

Xentuzumab  (Synonyms: BI 836845; Anti-Human IGF1 and IGF2 Recombinant Antibody)

Cat. No.: HY-P99274 Purity: 95.00%
COA

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Xentuzumab (Anti-Human IGF1 and IGF2 Recombinant Antibody; BI836845) is a recombinant a human monoclonal antibody that targets IGF ligands IGF1 and IGF2. Xentuzumab inhibits both of IGF1 and IGF2 growth-promoting signalling and suppresses AKT activation.

For research use only. We do not sell to patients.

CAS No. : 1417158-65-6

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5 mg USD 1090 In-stock
10 mg USD 1745 In-stock
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Based on 1 publication(s) in Google Scholar

Xentuzumab Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Xentuzumab

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  • References

  • Customer Review

Description

Xentuzumab (Anti-Human IGF1 and IGF2 Recombinant Antibody; BI836845) is a recombinant a human monoclonal antibody that targets IGF ligands IGF1 and IGF2. Xentuzumab inhibits both of IGF1 and IGF2 growth-promoting signalling and suppresses AKT activation[1].

IC50 & Target

IGF1, IGF2[1]
In Vitro

Xentuzumab (0.01-1 mM; 96 h) inhibits IGF type 1 receptor signaling and (0.1 μM; 48 h) AKT serine/threonine kinase (AKT) phosphorylation in VCaP, DuCaP, and MDA PCa 2b cell in a dose-dependent manner[1].
Xentuzumab (0.01-1 mM; 5-10 d) losses of antiproliferative activity against PTEN-null LNCaP or PC-3 cells when PTEN knockdown[1].
Xentuzumab (1 μM; 24-72 h) arrests cell cycle at sub-G1 phase and induces apoptosis in VCaP cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Xentuzumab Related Antibodies

Western Blot Analysis[1]

Cell Line: Prostate cancer VCaP cells
Concentration: 0.1 μM
Incubation Time: 24 h and 48 h
Result: Increased in cleaved caspase 3/7 and PARP.
Decreased the level of phosphorylation of FoxO3a (S253)/FoxO1 (T24).

Cell Cycle Analysis[1]

Cell Line: Prostate cancer VCaP cells
Concentration: 1 μM
Incubation Time: 24 h, 48 h, and 72 h
Result: Increased in cleaved caspase 3/7 and induces cell apoptosis.
Increased the sub-G1 cell population.
In Vivo

Xentuzumab (200 mg/kg i.p., once weekly for 10 weeks) in inhibits tumor growth in LuCaP 96CR patient-derived xenograft model in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Fox Chase CB17 severe combined immunodeficiency (SCID; CB17/lcr-Prkdc scid/lcrlcoCrl) male mice with LuCaP 96CR cell (s.c.)[1]
Dosage: 200 mg/kg
Administration: Intraperitoneal injection; once weekly for 10 weeks; sacrificed 6 hours after the last dose
Result: Resulted in significant reductions in tumor volume.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Xentuzumab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 lambda2
Purity & Documentation

Purity: 95.00%

COA (231 KB)

Inhibitory Antibodies User Guide (602 KB)
References
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Xentuzumab Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Xentuzumab1417158-65-6BI 836845 Anti-Human IGF1 and IGF2 Recombinant AntibodyBI836845BI-836845IGF-1RInsulin-like growth factor-1 receptorVCaPDuCaPMDA PCa 2bPTEN-null LNCaPInhibitorinhibitorinhibit

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