2. Signaling Pathways
  3. Cell Cycle/DNA Damage
    Cytoskeleton
  4. Kinesin
  5. Kinesin Isoform

Kinesin

 

Kinesin Related Products (25):

Cat. No. Product Name Effect Purity
  • HY-115570
    GW406108X
    		Inhibitor ≥98.0%
    GW406108X is a specific Kif15 (Kinesin-12) inhibitor with an IC50 of 0.82 uM in ATPase assays. GW406108X, a potent autophagy inhibitor, shows ATP competitive inhibition against ULK1 with a pIC50 of 6.37 (427 nM). GW406108X inhibits ULK1 kinase activity and blocks autophagic flux, without affecting the upstream signaling kinases mTORC1 and AMPK.
  • HY-13224
    AZD4877
    		Inhibitor 98.15%
    AZD4877 is another isostere to Ispinesib (HY-50759)and also a kinesin spindle protein (Eg5) inhibitor with IC50 of 2 nM.AZD4877 arrests cell mitosis, leads to the formation of the monopolar spindle phenotype and induces apoptosis. AZD4877 inhibits circulating peripheral blood mononuclear cells (PBMCs) and has anti-cancer activity.
  • HY-110208
    BRD9876
    		98.82%
    BRD9876 is the “rigor” inhibitor that locks kinesin-5 (Eg5) in a state with enhanced microtubules (MTs) binding, leading to bundling and stabilization of MTs. BRD9876 interacts with the tyrosine 104 residue that is part of the α4-α6 allosteric binding pocket. BRD9876 specifically targets microtubule-bound Eg5 and selectively inhibits myeloma over CD34 cells. BRD9876 has the potential for multiple myeloma (MM) research.
  • HY-15187A
    (R)-Filanesib
    		Inhibitor 98.80%
    (R)-Filanesib ((R)-ARRY-520) is the R-enantiomer of Filanesib (HY-15187). Filanesib is a synthetic kinesin spindle protein (KSP) inhibitor with an IC50 of 6 nM.
  • HY-160441
    MC-Val-Cit-PAB-Ispinesib
    		Inhibitor 99.85%
    MC-Val-Cit-PAB-Ispinesib (Compound 509) is a potent inhibitor of Eg5. MC-Val-Cit-PAB-Ispinesib is a click chemistry reagent.
  • HY-115570A
    (Z/E)-GW406108X
    		Inhibitor
    (Z/E)-GW406108X is a mixture of different configurations of GW406108X (HY-115570). GW406108X is a specific Kif15 (Kinesin-12) inhibitor with an IC50 of 0.82 uM.
  • HY-162518
    Eg5-IN-3
    		Inhibitor
    Eg5-IN-3 (5) is an Eg5 inhibitor that targets the novel allosteric pocket (α4/α6/L11). Eg5-IN-3 (5) causes tubulin assembly distortion with irregular morphology, resulting in a typical mitotic arrest similar to Monastrol (HY-101071A).
  • HY-14846A
    Litronesib Racemate
    		99.20%
    Litronesib Racemate (LY2523355 Racemate) is the racemate of litronesib. Litronesib is a selective, allosteric inhibitor of kinesin Eg5.
  • HY-118961
    SR31527 chloride
    		Inhibitor
    SR31527 chloride is a potent KIFC1 inhibitor with an IC50 value of 6.6 µM. SR31527 chloride decreases cell viability and colony formation.
  • HY-101071
    (S)-Monastrol
    		Inhibitor
    (S)-Monastrol ((+)-Monastrol) is an allosteric inhibitor of the mitotic kinesin Eg5 that exhibits an antiproliferative effect against several cancer cell lines. (S)-Monastrol arrests mammalian cells in mitosis with monopolar spindles.
  • HY-15187B
    Filanesib TFA
    		Inhibitor
    Filanesib TFA (ARRY-520 TFA) is a selective kinesin spindle protein (KSP) inhibitor, with an IC50 of 6 nM for human KSP. Filanesib TFA induces cell death by apoptosis in vitro. Filanesib TFA has potent anti-proliferative activity.
  • HY-14661
    SB-743921 free base
    		Inhibitor
    SB-743921 free base is a potent selective inhibitor of the mitotic kinesin KSP (Eg5), with a Ki of 0.1 nM. SB-743921 free base can induce mitotic arrest, block cell cycle progression, induce apoptosis, and can be used in the research of myeloma, leukemia and other diseases.
  • HY-146146
    Kolavenic acid analog
    		Inhibitor
    Kolavenic acid analog (KAA) is an anticancer agent. Kolavenic acid analog shows strong activity against HSET-overproducing yeast cells. Kolavenic acid analog inhibits centrosome clustering in human cancer cells containing high HSET levels and supernumerary centrosomes.
  • HY-N11128
    Solidagonic acid
    		Inhibitor
    Solidagonic acid inhibits HSET motor activity by promoting the conversion from abnormal monopolar to bipolar spindles. Solidagonic acid suppresses fission yeast cell death and enables reversion of the mitotic spindles from a monopolar to bipolar morphology. Solidagonic acid showed the growth inhibitory activity on the seedlings of Lactuca sativa L. and Lolium multiflorum Lam.
  • HY-155134
    Eg5-IN-1
    		Inhibitor
    Eg5-IN-1 (compound 6c) is a potent kinesin family motor protein (Eg5) inhibitor with an IC50 value of 1.97 µM. Eg5-IN-1 can be used in research of cancer.
  • HY-RS07257
    Kif12 Mouse Pre-designed siRNA Set A
    		Inhibitor

    Kif12 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Kif12 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
  • HY-RS07255
    KIF11 Human Pre-designed siRNA Set A
    		Inhibitor

    KIF11 Human Pre-designed siRNA Set A contains three designed siRNAs for KIF11 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
  • HY-RS07258
    Kif12 Rat Pre-designed siRNA Set A
    		Inhibitor

    Kif12 Rat Pre-designed siRNA Set A contains three designed siRNAs for Kif12 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
  • HY-RS07256
    KIF12 Human Pre-designed siRNA Set A
    		Inhibitor

    KIF12 Human Pre-designed siRNA Set A contains three designed siRNAs for KIF12 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
  • HY-15187C
    Filanesib hydrochloride
    		Inhibitor
    Filanesib (ARRY-520) hydrochloride is a selective and noncompetitive kinesin spindle protein (KSP) inhibitor, with an IC50 of 6 nM for human KSP. Filanesib induces cell death by apoptosis in vitro. Filanesib has potent anti-proliferative activity.