2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. MMP

MMP

Matrix metalloproteinases

MMP

Related Products

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MMPs (Matrix metalloproteinases) are zinc-dependent endopeptidases. The MMPs belong to a larger family of proteases known as the metzincin superfamily. MMPs are capable of degrading all kinds of extracellular matrix proteins, but also can process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands and chemokine/cytokine inactivation. MMPs are also thought to play a major role on cell behaviors such as cell proliferation, migration, differentiation, angiogenesis, apoptosis, and host defense. MMP-2 and MMP-9 are thought to be important in metastasis. MMP-1 is thought to be important in rheumatoid arthritis and osteoarthritis. Recent data suggests active role of MMPs in the pathogenesis of Aortic Aneurysm. Excess MMPs degrade the structural proteins of the aortic wall. Disregulation of the balance between MMPs and TIMPs is also a characteristic of acute and chronic cardiovascular diseases.

MMP Isoform Specific Products:

MMP Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-E70196
    Endoproteinase Asp-N
    		Inhibitor
    Endoproteinase Asp-N (Asp-N) is a metalloprotease that can specifically cleave the N-terminal side of aspartyl and cysteic acid residues.
    Endoproteinase Asp-N
  • HY-147936
    TP0556351
    		Inhibitor
    TP0556351 is a potent and selective matrix metalloproteinase-2 (MMP2) inhibitor with an IC50 value of 0.2 nM. TP0556351 reduces the amount of collagen in the lungs of a Bleomycin-induced pulmonary fibrosis mouse model. TP0556351 can be used for researching idiopathic pulmonary fibrosis (IPF).
    TP0556351
  • HY-N12960
    Artobiloxanthone
    		Inhibitor
    Artobiloxanthone (Compound AA3) exhibits antitumor activity, particularly against oral squamous cell carcinoma (OSCC). Artobiloxanthone inhibits Akt/mTOR pathway and STAT3 pathway, inhibits proliferation of SAS and T.Tn (with IC50 of 11 and 22 μM), and inhibits the cancer cell migration. Artobiloxanthone arrests cell cycle at S phase, and induces apoptosis in OSCC cells through activation of caspase 3/9.
    Artobiloxanthone
  • HY-B0261A
    Meloxicam sodium
    		Inhibitor
    Meloxicam sodium is a non-steroidal anti-inflammatory agent, inhibits COX activity, with IC50s of 0.49 µM and 36.6 µM for COX-2 and COX-1, respectively.
    Meloxicam sodium
  • HY-NP120
    Highly purified Type V collagen, from human placenta
    Highly purified Type V collagen, from human placenta (Human Placenta Type V collagen, immunization grade) is an immune grade collagen derived from human placenta, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs.
    Highly purified Type V collagen, from human placenta
  • HY-NP105
    Highly purified Type IX collagen, from bovine articular cartilage
    Highly purified Type IX collagen, from bovine articular cartilage (Bovine Type IX collagen, immunization grade) is an immune grade collagen derived from bovine articular cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs.
    Highly purified Type IX collagen, from bovine articular cartilage
  • HY-N6860
    Lucidenic acid C
    		Inhibitor
    Lucidenic acid C is a natural compound isolated from Ganoderma lucidum, inhibits PMA-induced MMP-9 activity, with anti-invasive effect on hepatoma cells.
    Lucidenic acid C
  • HY-149700
    ROCK2-IN-7
    ROCK2-IN-7 is a kinase inhibitor targeting to ROCK2. ROCK2-IN-7 inhibits ROCK2/pSTAT3 Signaling. ROCK2-IN-7 suppresses systemic immunity activation and attenuates inflammation in psoriasis model.
    ROCK2-IN-7
  • HY-N0225R
    (-)-Epigallocatechin (Standard)
    		Inhibitor
    (-)-Epigallocatechin (Standard) is the analytical standard of (-)-Epigallocatechin. This product is intended for research and analytical applications. (-)-Epigallocatechin (Epigallocatechin) is the most abundant flavonoid in green tea, can bind to unfolded native polypeptides and prevent conversion to amyloid fibrils.
    (-)-Epigallocatechin (Standard)
  • HY-162453
    Anticancer agent 204
    		Inhibitor
    Anticancer agent 204 (Compound 6), a cinnamide fluorinated derivative, possesses anticancer activity. Anticancer agent 204 can arrest the cell cycle of HepG2 cells in the G1 phase and induce apoptosis by reducing the level of mitochondrial membrane polarization (MMP).
    Anticancer agent 204
  • HY-123736
    Ro 32-7315
    		Inhibitor
    Ro 32-7315 is a TNF-α converting enzyme (TACE) inhibitor.
    Ro 32-7315
  • HY-P10174
    ADAM-17 Substrate
    ADAM-17 Substrate is a fluorescent substrate of ADAM.
    ADAM-17 Substrate
  • HY-NP130
    Highly purified Type II collagen, from goat articular cartilage
    Highly purified Type II collagen, from goat articular cartilage (Goat Type II collagen, immunization grade) is an immune grade collagen derived from goat articular cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs.
    Highly purified Type II collagen, from goat articular cartilage
  • HY-132917
    ADAM8-IN-1
    		Inhibitor
    ADAM8-IN-1 is a potent ADAM8 inhibitor with an IC50 value of 73 nM.
    ADAM8-IN-1
  • HY-NP119
    Highly purified Type V collagen, from human amnion
    Highly purified Type V collagen, from human amnion (Human Amnion Type V collagen, immunization grade) is an immune grade collagen derived from human amnion, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs.
    Highly purified Type V collagen, from human amnion
  • HY-153913
    MMP-9-IN-7
    		Inhibitor
    MMP-9-IN-7 is a potent MMP9 inhibitor with an IC50 of 0.52 μM in proMMP9/MMP3 P126 activation assay. MMP-9-IN-7 is extracted from patent WO2012162468 (example 59), and can be used for MMP9/MMP13 mediated syndrome research.
    MMP-9-IN-7
  • HY-114581
    U27391
    		Inhibitor
    U27391 is a metalloproteinase inhibitor. U27391 inhibits rhIL-1β Induced proteoglycan loss.
    U27391
  • HY-137521
    Z-PDLDA-NHOH
    Z-PDLDA-NHOH is a potent and specific inhibitor of vertebrate collagenase.
    Z-PDLDA-NHOH
  • HY-N0318R
    Salvianolic acid A (Standard)
    Salvianolic acid A (Standard) is the analytical standard of Salvianolic acid A. This product is intended for research and analytical applications. Salvianolic acid A could protect the blood brain barrier through matrix metallopeptidase 9 (MMP-9) inhibition and anti-inflammation.
    Salvianolic acid A (Standard)
  • HY-121096
    Funalenone
    		Inhibitor
    Funalenone (BMS-304245) is a MraY + MurG inhibitor with an IC50 of 25.5 μM in a MraY + MurG membrane plate assay. Funalenone inhibits Staphylococcus aureus (A15090) with an MIC of 64 μg/mL. Funalenone also inhibits MMP-1 with an IC50 of 170 μM.
    Funalenone
Cat. No. Product Name / Synonyms Species Source
Cat. No. Product Name / Synonyms Application Reactivity
MMP Isoform Comparison

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