2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Endogenous Metabolite

Endogenous Metabolite

Endogenous Metabolite

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Metabolite results when a drug is metabolized into a modified form which continues to produce effects. A metabolome in a given body fluid is influenced by endogenous factors such as age, sex, body composition and genetics as well as underlying pathologies.The levels of the enormous array of unique small-molecule metabolites are usually kept tightly regulated by the activity of a very large array of enzymes and transporters responsible for the production, transformation, degradation, and compartmentalization of these small molecules.The levels of the endogenous small molecules present in the brain are normally tightly regulated.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-113448
    CE(20:3(8Z,11Z,14Z))
    Cholesteryl homo-γ-linolenate is a cholesterol ester. It accumulates in the adrenal gland of rabbits fed a diet high in linolenic acid.1 Levels of cholesteryl homo-γ-linolenate are decreased and positively correlate with cognitive decline in HIV-infected humans.
    CE(20:3(8Z,11Z,14Z))
  • HY-B0275R
    Oxytetracycline (Standard)
    Oxytetracycline (Standard) is the analytical standard of Oxytetracycline. This product is intended for research and analytical applications. Oxytetracycline is an antibiotic belonging to the tetracycline class. Oxytetracycline potent inhibits Gram-negative and Gram-positive bacteria. Oxytetracycline is a protein synthesis inhibitor and prevents the binding from aminoacil-tRNA to the complex m-ribosomal RNA. Oxytetracycline also possesses anti-HSV-1 activity.
    Oxytetracycline (Standard)
  • HY-139101
    Guanosine 5'-triphosphate-5'-adenosine
    Guanosine 5'-triphosphate-5'-adenosine (GpppA), a 5′ cap analog, can be used for RNA synthesis in vitro. Guanosine 5'-triphosphate-5'-adenosine is a fluorescent substrate analog.
    Guanosine 5'-triphosphate-5'-adenosine
  • HY-101240
    Propranolol glycol
    Propranolol glycol is a metabolite of propranolol (HY-B0573B). Propranolol glycol shows instantaneous anticonvulsant activity.
    Propranolol glycol
  • HY-W750600
    Acetonitrile-15N
    Acetonitrile-15N (Methyl cyanide-15N) is a stable isotope labeled organic compound with important applications in metabolic research and molecular labeling. Acetonitrile-15N is used in biolabeling experiments to track metabolic pathways and help understand the chemical reaction mechanisms in organisms. Acetonitrile-15N is also widely used in environmental science to study the migration and transformation processes of pollutants.
    Acetonitrile-<sup>15</sup>N
  • HY-W654020
    Propyl paraben-13C6
    Propyl paraben-13C6 (Propyl parahydroxybenzoate-13C6) is 13C labeled Propylparaben. Propylparaben (Propyl parahydroxybenzoate) is an antibacterial preservative that can be produced by plants and bacteria. Propylparaben is commonly used in cosmetics, pharmaceuticals and foods. Propylparaben disrupts follicular growth and steroidogenic function by altering cell cycle, apoptosis and steroidogenic pathways. Propylparaben also reduced sperm count and motility in rats.
    Propyl paraben-<sup>13</sup>C<sub>6</sub>
  • HY-168373
    1-Stearoyl-2-Eicosapentaenoyl-sn-glycero-3-PC
    1-Stearoyl-2-eicosapentaenoyl-sn-glycero-3-PC is a phospholipid that can be found in human red blood cells (RBCs).
    1-Stearoyl-2-Eicosapentaenoyl-sn-glycero-3-PC
  • HY-W698343
    NG-Hydroxy-L-arginine acetate
    NG-Hydroxy-L-arginine acetate (NOHA acetate) serves as a physiological inhibitor of arginase, playing a crucial role in the conversion of arginine to nitric oxide and citrulline by nitric oxide synthase.
    NG-Hydroxy-L-arginine acetate
  • HY-W016498R
    Paraxanthine (Standard)
    Paraxanthine (Standard) is the analytical standard of Paraxanthine. This product is intended for research and analytical applications. Paraxanthine, a caffeine metabolite, provides protection against Dopaminergic cell death via stimulation of Ryanodine Receptor Channels.
    Paraxanthine (Standard)
  • HY-18258R
    Berberine (chloride) (Standard)
    Berberine (chloride) (Standard) is the analytical standard of Berberine (chloride). This product is intended for research and analytical applications. Berberine chloride is an alkaloid that acts as an antibiotic. Berberine chloride induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Antineoplastic properties.
    Berberine (chloride) (Standard)
  • HY-W106641
    (Z)-7-Dodecen-1-ol
    (Z)-7-Dodecen-1-ol inhibits the effect of the attractant Z-7-dodecen-1-yl acetate.
    (Z)-7-Dodecen-1-ol
  • HY-168360
    Bufotenidine iodide
    Bufotenidine iodide is a component found in toad venom and belongs to the indole alkaloid class.
    Bufotenidine iodide
  • HY-113018
    Ibuprofen acyl-β-D-glucuronide
    Ibuprofen acyl-β-D-glucuronide (Ibuprofen glucuronide) is a selective TRPA1 antagonis. Ibuprofen acyl-β-D-glucuronide reduces AITC-evoked calcium response with an IC50 value of 60μM.
    Ibuprofen acyl-β-D-glucuronide
  • HY-17438A
    Cidofovir dihydrate
    Cidofovir (GS 0504; HPMPC; (S)-HPMPC) dihydrate is an acyclic monophosphate nucleotide analogue and CMV inhibitor with antiviral activity. Cidofovir dihydrate inhibits cytomegalovirus (CMV) replication by selectively inhibiting viral DNA polymerase. Cidofovir dihydrate induces apoptosis and can be used in studies of AIDS cytomegalovirus retinitis, herpes, and cancer. Cidofovir dihydrate also has anti-orthopoxvirus and anti-variola activities.
    Cidofovir dihydrate
  • HY-W753582
    1-Methyl-2-azaadamantane-N-oxyl
    1-Methyl-2-azaadamantane-N-oxyl (1-Me-AZADO), a less sterically hindered nitroxyl radical renowned for its stability and outstanding catalytic performance.
    1-Methyl-2-azaadamantane-N-oxyl
  • HY-W040268S1
    1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine-d9
    1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine-d9 is deuterium labeled 1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine. 1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine is a phospholipid that is a major component of the lipid bilayer that surrounds cells and provides stability to the membrane.
    1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine-d<sub>9</sub>
  • HY-W015466S1
    Acetylvaline-13C2
    Acetylvaline-13C2 is the 13C-labeled Acetylvaline. Acetylvaline is an endogenous metabolite.
    Acetylvaline-<sup>13</sup>C<sub>2</sub>
  • HY-W744160
    Stigmasterol-d6
    Stigmasterol-d6 is deuterium-labeled Stigmasterol (HY-N0131).
    Stigmasterol-d<sub>6</sub>
  • HY-W654000
    Cyclic GMP-13C,15N2
    Cyclic GMP-13C,15N2 is 13C and 15N labeled Cyclic GMP. Cyclic GMP (cGAMP) is an endogenous second messenger that triggers interferon production in response to cytoplasmic DNA. Cyclic GMP activates the stimulator of interferon genes (STING), activating a signaling cascade that leads to the production of type I interferons and other immune mediators.
    Cyclic GMP-<sup>13</sup>C,<sup>15</sup>N<sub>2</sub>
  • HY-B0660S1
    Eicosapentaenoic acid 1,2,3,4,5-13C5
    Eicosapentaenoic acid 1,2,3,4,5-13C5 (EPA 1,2,3,4,5-13C, FA 20:5-13C5) is 13C labeled Eicosapentaenoic Acid. Eicosapentaenoic Acid (EPA) is an orally active Omega-3 long-chain polyunsaturated fatty acid (ω-3 LC-PUFA). Eicosapentaenoic Acid exhibits a DNA demethylating action that promotes the re-expression of the tumor suppressor gene CCAAT/enhancer-binding protein δ (C/EBPδ). Eicosapentaenoic Acid activates RAS/ERK/C/EBPβ pathway through H-Ras intron 1 CpG island demethylation in U937 leukemia cells. Eicosapentaenoic Acid can promote relaxation of vascular smooth muscle cells and vasodilation.
    Eicosapentaenoic acid 1,2,3,4,5-<sup>13</sup>C<sub>5</sub>
Cat. No. Product Name / Synonyms Application Reactivity