2. Signaling Pathways
  3. Cell Cycle/DNA Damage
    Cytoskeleton
  4. Microtubule/Tubulin

Microtubule/Tubulin

Microtubule/Tubulin

Related Products

PDF 0.04 MB

Microtubules are a component of the cytoskeleton, found throughout the cytoplasm. These tubular polymers of tubulin can grow as long as 50 micrometres, with an average length of 25 µm, and are highly dynamic. The outer diameter of a microtubule is about 24 nm while the inner diameter is about 12 nm. Microtubules are found in eukaryotic cells and are formed by the polymerization of a dimer of two globular proteins, alpha and beta tubulin. Tubulin is one of several members of a small family of globular proteins. The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family which is present only in kinetoplastid protozoa. The most common members of the tubulin family are α-tubulin and β-tubulin, the proteins that make up microtubules. Microtubules are very important in a number of cellular processes. They are involved in maintaining the structure of the cell.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-147725
    Microtubule inhibitor 4
    		Inhibitor
    Microtubule inhibitor 4 (compound 2) is a potent microtubule inhibitor. Microtubule inhibitor 4 shows cytotoxicity with IC50s of 4.0, 3.2, 2.1 nM for NCI-H460, BxPC-3, HT-29 cells, respectively. Microtubule inhibitor 4 shows the inhibition of tubulin polymerization.
    Microtubule inhibitor 4
  • HY-P3894
    P34cdc2 Kinase Fragment
    		Modulator
    P34cdc2 Kinase Fragment is associated with the completion of DNA replication in yeast mitosis. P34cdc2 Kinase can phosphorylate mitogen-activated protein 2 (MAP2) to regulate microtubules polymerization in Xenopus oocytes meiosis.
    P34cdc2 Kinase Fragment
  • HY-147887
    Tubulin inhibitor 28
    		Inhibitor
    Tubulin inhibitor 28 (compound 2g) is a potent tubulin inhibitor with an IC50 value of 1.2 µM. Tubulin inhibitor 28 shows anti-proliferative activity for MCF-7 cells.
    Tubulin inhibitor 28
  • HY-B0621S
    Triclabendazole-d3
    Triclabendazole-d3 is the deuterium labeled 4-Methoxybenzylamine[1].
    Triclabendazole-d<sub>3</sub>
  • HY-159653
    MASTL-IN-5
    		Inhibitor
    MASTL-IN-5 (compound 11) is a MASTL (microtubule-associated serine/threonine kinase-like) inhibitor, with a Ki of 0.018 nM.
    MASTL-IN-5
  • HY-146377
    Tubulin polymerization-IN-19
    		Inhibitor
    Tubulin polymerization-IN-19 (compound 4) is a potent inhibitor of tubulin polymerization. Tubulin polymerization-IN-20 has the potential for the research of breast cancers and chemoresistant colon cancers.
    Tubulin polymerization-IN-19
  • HY-125374A
    Larotaxel dihydrate
    		Inhibitor
    Larotaxel (dihydrate) (XRP9881 (dihydrate)), a new taxane compound prepared by partial synthesis from 10-deacetyl baccatin III, is active against tumors.
    Larotaxel dihydrate
  • HY-146358
    Anticancer agent 49
    		Inhibitor
    Anticancer agent 49 (compound 69) is a broad spectrum anticancer agent. Anticancer agent 49 inhibits tubulin polymerization. Anticancer agent 49 shows antiproliferative activity. Anticancer agent 49 has the potential for the research of solid and hematological tumors.
    Anticancer agent 49
  • HY-105529
    Indicine N-oxide
    Indicine N-oxide (NSC 132319), a pyrrolizidine alkaloid, is an antitumor agent for pediatric cancer and solid tumors research.
    Indicine N-oxide
  • HY-161075
    Microtubule inhibitor 8
    		Inhibitor
    Microtubule inhibitor 8 (MP-HJ-1b) is a potent inhibitor of microtubule. Microtubule inhibitor 8 triggers cell death through ferroptosis. Microtubule inhibitor 8 has anti-tumor effect.
    Microtubule inhibitor 8
  • HY-N3950
    Glochidiol
    		Inhibitor
    Glochidiol is an orally active tubulin polymerization inhibitor with an IC50 of 2.76 μM. Glochidiol shows anti-cancer activity.
    Glochidiol
  • HY-169418
    Tubulin polymerization-IN-71
    		Inhibitor
    Tubulin polymerization-IN-71 (Compound 4k) is an inhibitor for tubulin polymerization with an IC50 of 3.06 μM. Tubulin polymerization-IN-71 inhibits the proliferation of cancer cell MG-63 and U2OS with IC50 of 0.08-0.14 μM. Tubulin polymerization-IN-71 arrests the cell cycle at G2/M phase, and induces apoptosis in MG-63.
    Tubulin polymerization-IN-71
  • HY-116915
    Synstab A
    		Modulator
    Synstab A is a mitosis modulator to promote interactions between α- and β-tubulin. Synstab A can polymerizes microtubules from purified tubulin, and produces microtubule bundles in interphase cells.
    Synstab A
  • HY-118588
    Diminutol
    		Inhibitor
    Diminutol is an inhibitor for NADP-dependent quinone oxidoreductase (NQO1), that is involved in microtubule morphogenesis and cell devision.
    Diminutol
  • HY-77574
    7-xylosyltaxol
    		Inhibitor
    7-xylosyltaxol(Taxol-7-xyloside) is a taxol (Paclitaxel) derivative; Paclitaxel binds to tubulin and inhibits the disassembly of microtubules.
    7-xylosyltaxol
  • HY-147947
    Tubulin polymerization-IN-30
    		Inhibitor
    Tubulin polymerization-IN-30 (compound 6e) is a potent Tubulin polymerization inhibitor. Tubulin polymerization-IN-30 is a colchicine binding site inhibitor. Tubulin polymerization-IN-30 can disrupt intracellular microtubule organization, arrest cell cycle at the G2/M phase. Tubulin polymerization-IN-30 exhibits the high potency against the cancer cell lines including SGC-7901, A549 and HeLa, with IC50 values of 2.16, 2.21, and 0.403 μM.
    Tubulin polymerization-IN-30
  • HY-144299
    Tubulin polymerization-IN-5
    		Inhibitor
    Tubulin polymerization-IN-5 (compound 20q) is a potent tubulin inhibitor with potential anticancer activities. Tubulin polymerization-IN-5 can arrest ESCC cells at G2/M phase and cause cells apoptosis.
    Tubulin polymerization-IN-5
  • HY-162625
    Tubulin inhibitor 47
    		Inhibitor
    Tubulin inhibitor 47 (compound C11) is a potent tubulin inhibitor. Tubulin inhibitor 47 induces apoptosis and cell cycle arrest at the M phase. Tubulin inhibitor 47 shows anti-tumor activity.
    Tubulin inhibitor 47
  • HY-161747
    Tubulin inhibitor 46
    		Inhibitor
    Tubulin inhibitor 46 (Compound 21) is a potent tubulin assembly inhibitor. Tubulin inhibitor 46 has antiproliferative activities, with GI50 values of 0.0095-33 μM for cancer and non-cancerous cells. Tubulin inhibitor 46 can be used for the reserch of cancer.
    Tubulin inhibitor 46
  • HY-173039
    α-Tubulin polymerization-IN-1
    		Inhibitor
    α-Tubulin polymerization-IN-1 (Compound 8l) is an inhibitor for α-Tubulin polymerization. α-Tubulin polymerization-IN-1 modulates the NRF2/KEAP-1 signaling pathway, induces ROS generation in PC-3 cell, thereby inducing apoptosis in PC-3. α-Tubulin polymerization-IN-1 inhibits the proliferation of PC-3 cell with a GI50 of 0.17 µM, arrests the cell cycle at G2/M phase. α-Tubulin polymerization-IN-1 exhibits antitumor efficacy in mouse model.
    α-Tubulin polymerization-IN-1
Cat. No. Product Name / Synonyms Application Reactivity