Neurokinin Receptor

Neurokinin Receptor Related Products (162):

By Effects:	Inhibitors (12) Controls (2) Agonists (23) Antagonists (84) Activator (1) Modulators (4)

Cat. No.	Product Name	Effect	Purity

HY-19429A

SLV-317	Antagonist
SLV-317 is an antagonist of the neurokinin-1 receptor with oral activity. SLV-317 can effective antagonist of substance P-induced effects.

HY-109171S

Elinzanetant-d₃	Antagonist
Elinzanetant-d₃ (NT-814-d₃) is deuterium labeled Elinzanetant. Elizanetant (NT-814) is an orally active, selective NK-1,3 receptor antagonist. Elizanetant can reduce the levels of estradiol and progesterone, and is used in the study of vascular motor symptoms and sleep disorders related to menopause in women.

HY-107693

SSR 146977 hydrochloride	Antagonist
SSR 146977 hydrochloride is a potent and selective antagonist of the tachykinin NK₃ receptor. SSR 146977 hydrochloride can be used in the study of psychiatric disorders and airway inflammation.

HY-120308

(R)-Nolpitantium	Antagonist
(R)-Nolpitantium is the R-enantiomer of Nolpitantium (HY-108479). Nolpitantium (SR140333) is a potent, selective, competitive, non-peptide tachykinin NK₁ receptor antagonist. Nolpitantium blocks the activation of rat thalamic neurons after nociceptive stimulation.

HY-169501

WIN 62577	Antagonist
WIN 62577 is a species-selective tachykinin NK1 receptor antagonist. WIN 62577 is also an allosteric enhancer with micromolar potency at M3 receptors. WIN 62577 exhibits potent antiviral activity against SARS-CoV-2.

HY-14751R

Rolapitant (Standard)	Antagonist
Rolapitant (Standard) is the analytical standard of Rolapitant. This product is intended for research and analytical applications. Rolapitant (SCH619734) is a potent, selective, long-acting and orally active neurokinin 1 (NK1) receptor antagonist with a K_i of 0.66 nM. Rolapitant does not interact with CYP3A4. Rolapitant shows potent anti-emetic activity in a ferret emesis model.

HY-118378

ZD6021	Antagonist
ZD6021 is an orally active Neurokinin 1 Receptor antagonist, with K_i values of 0.12 nM for NK1 and 0.62 nM for NK2. At a concentration of 100 nM, ZD6021 has a pK_B value of 8.9 for human pulmonary artery NK1 receptors, and a pK_B value of 7.3 for human bronchial NK2 receptors. ZD6021 effectively reduces ASMSP-induced plasma protein extravasation in guinea pigs, with an ED₅₀ of 0.5 mg/kg, and also decreases NK2 mediated bronchoconstriction, with an ED₅₀ of 13 mg/kg.

HY-16346R

Netupitant (Standard)	Antagonist
Netupitant (Standard) is the analytical standard of Netupitant. This product is intended for research and analytical applications. Netupitant (CID-6451149) is a highly potent, selective and orally active neurokinin-1 (NK₁) receptor antagonist with a K_i of 0.95 nM for hNK₁ in CHO cells. Netupitant has antiemetic affect.

HY-116958

SCH 206272	Antagonist
SCH 206272 is a selective antagonist of the tachykinin (NK) receptor. SCH 206272 inhibits binding at human tachykinin NK(1), NK(2), and NK(3) receptors (K_i = 1.3, 0.4, and 0.3 nM, respectively). SCH 206272 has an orally active.

HY-105264

FK224	Antagonist
FK224 is a tachykinin receptor antagonist. FK224 reduces the tracheal plasma extravasation induced by substance P (SP) and neurokinin A (NKA).

HY-117216

L-703606	Antagonist
L-703606 is a potent, selective antagonist of NK1 receptor. L-703606 can be used for study of gastric acid secretion.

HY-P0061B

Vapreotide diacetate	Antagonist
Vapreotide diacetate is a neurokinin-1 (NK1) receptor antagonist, with an IC₅₀ of 330 nM.

HY-G0012S

Monohydroxy Netupitant-d₆	Agonist
Monohydroxy Netupitant-d₆ is the deuterium labeled Monohydroxy Netupitant, which is a metabolite of Netupitant.

HY-14407AR

Fosaprepitant (dimeglumine) (Standard)	Antagonist
Fosaprepitant (dimeglumine) (Standard) is the analytical standard of Fosaprepitant (dimeglumine). This product is intended for research and analytical applications. Fosaprepitant dimeglumine (MK-0517) is a proagent of Aprepitant (HY-10052). Fosaprepitant dimeglumine is a neurokinin-1 receptor antagonist, which is development for the prevention of chemotherapy-induced nausea and vomiting (CINV).

HY-P2603

Bz-Dab(NBD)-AwFpP-Nle-NH2	Antagonist
Bz-Dab(NBD)-AwFpP-Nle-NH2 (Compound 5B) is a potent fluorescent antagonist of NK2 receptor, with a pK_i of 8.87 nM (Ex=340 nm, Em=505 nm).

HY-G0012

Netupitant metabolite Monohydroxy Netupitant	Agonist
Monohydroxy Netupitant is the metabolite of Netupitant, which is a highly selective NK1 receptor antagonist.

HY-P2436

L-659837	Antagonist
L-659837 is a NK2 receptor antagonist, and can antagonize GR 64349 (HY-P1278)-induced contraction. L-659837 can be used for study of urinary bladder disorders.

HY-118356

WIN 62,577	Antagonist
WIN 62,577 is a rat-specific, but non-human, NK1 receptor antagonist. WIN 62,577 interacts with M1-M4 mAChRs and is an allosteric enhancer of acetylcholine affinity targeting the M3 receptor.

HY-P0250

Kassinin
Kassinin is a peptide derived from the Kassina frog. It belongs to tachykinin family of neuropeptides. It is secreted as a defense response, and is involved in neuropeptide signalling.

HY-P0236

Neurokinin A(4-10)	Agonist
Neurokinin A (4-10) is a tachykinin NK₂ receptor agonist.

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