Neuropeptide Y Receptor

Neuropeptide Y Receptor Related Products (91):

By Effects:	Inhibitors (2) Agonists (41) Antagonists (28) Activator (1) Modulators (4)

Cat. No.	Product Name	Effect	Purity

HY-100717

HT-2157	Antagonist	≥98.0%
HT-2157 (SNAP 37889) is a selective, high-affinity, competitive antagonists of galanin-3 receptor (Gal₃).

HY-108625

SHA 68	Antagonist	99.84%
SHA 68 is a potent and selective non-peptide neuropeptide S receptor (NPSR) antagonist with IC₅₀s of 22.0 and 23.8 nM for NPSR Asn¹⁰⁷ and NPSR Ile¹⁰⁷, respectively. SHA 68 has limited the blood-brain barrier (BBB) penetration and the activity in neuralgia.

HY-P1127

Galanin (1-30), human	Agonist	99.90%
Galanin (1-30), human is a 30-amino acid neuropeptide, and acts as an agonist of GalR1 and GalR2 receptors, with K_is of both 1 nM.

HY-107723

CGP71683 hydrochloride	Antagonist	99.90%
CGP71683 hydrochloride is a competitive neuropeptide Y5 receptor antagonist with a K_i of 1.3 nM, and shows no obvious activity at Y1 receptor (K_i, >4000 nM) and Y2 receptor (K_i, 200 nM) in cell membranes.

HY-P1723

Spexin	Agonist	98.69%
Spexin is a conserved peptide plays roles of neurotransmitter/neuromodulator and endocrine factor. Spexin peptide contains numerous aromatic amino acids and is probably amidated.

HY-P1128

Galanin (swine)	Agonist	98.99%
Galanin (swine), a neuropeptide, consists of 29 amino acids and contains a C-terminal amidated glycine. Galanin (swine) inhibits basal and stimulated insulin secretion both in vivo and in vitro under a variety of experimental conditions. Galanin (swine) is a galanin receptor agonist with pK_is of 9.63, 9.49, 9.02, 8.98, 8.01 and 8.14 at human GAL1, rat GAL1, human GAL2, rat GAL2, human GAL3 and rat GAL3 respectively.

HY-P4060A

Pancreatic polypeptide TFA	Agonist	99.47%
Pancreatic polypeptide TFA is a neuropeptide Y (NPY) Y4/Y5 receptor agonist.

HY-P10291

[Pro34]Neuropeptide Y, porcine	Agonist
[Pro34]Neuropeptide Y, porcine is a selective NPY receptor (Y1 receptor) agonist. [Pro34]Neuropeptide Y, porcine evokes vasoconstrictions in the guinea pig caval vein.

HY-P0198A

Neuropeptide Y (human,rat,mouse) (TFA)		98.60%
Neuropeptide Y (human) TFA is involved in Alzheimer's disease (AD) and protects rat cortical neurons against β-Amyloid toxicity.

HY-P1840

Galanin Receptor Ligand M35	Antagonist	99.84%
Galanin Receptor Ligand M35 is a high-affinity ligand and antagonist of galanin receptor (K_d=0.1 nM). Galanin Receptor Ligand M35 exerts a K_i values of 0.11 and 2.0 nM for human galanin receptor type 1 and 2, respectively.

HY-P1130

M871	Antagonist	99.80%
M871 (Galanin-(2-13)-Glu-His-(Pro)3-(Ala-Leu)2-Ala-amide) is a selective galanin receptor type 2 (GalR2) antagonist. M871 exhibits K_i values of 13.1 nM and 420 nM for GalR2 and GalR1, respectively. M871 can be used for research on GalR2-related diseases (such as epilepsy, pain).

HY-14450

JNJ-31020028	Antagonist	98.02%
JNJ-31020028 is a selective and brain penetrant antagonist of neuropeptide Y Y2 receptor with pIC₅₀ values of 8.07 and 8.22 for human and rat Y2 receptor, respectively. JNJ-31020028 can be used for the research of nervous disease.

HY-P1514

Peptide YY (PYY), human		99.77%
Peptide YY (PYY) is a gut hormone that regulates appetite and inhibits pancreatic secretion. Peptide YY (PYY) can mediate its effects through the Neuropeptide Y receptors.

HY-14423

Velneperit	Antagonist	99.21%
Velneperit (S-2367) is a novel neuropeptide Y (NPY) Y5 receptor antagonist.

HY-P1601

Neuropeptide Y(29-64)		99.47%
Neuropeptide Y(29-64) is a 36 amino acid peptide, a fragment of Neuropeptide Y.

HY-P0198

Neuropeptide Y (human,rat,mouse)		99.38%
Neuropeptide Y (human,rat,mouse) is involved in Alzheimer's disease (AD) and protects rat cortical neurons against β-Amyloid toxicity.

HY-107734

L 152804	Antagonist	99.48%
L 152804 is an orally active and selective neuropeptide Y Y5 receptor (NPY5-R) antagonist, with a K_i of 26 nM for hY5. L 152804 causes weight loss in diet-induced obese mice by modulating food intake and energy expenditure.

HY-P0199

Pancreatic Polypeptide, human	Agonist	99.58%
Pancreatic Polypeptide, human is a C-terminally amidated 36 amino acid peptide, which acts as a neuropeptide Y (NPY) Y4/Y5 receptor agonist.

HY-101986A

BIIE-0246 hydrochloride	Antagonist	≥99.0%
BIIE-0246 hydrochloride (AR-H 053591 hydrochloride) is a potent and selective NPY2R (neuropeptide Y receptor 2) antagonist with an IC₅₀ value of 15 nM for rat [¹²⁵I]PYY_3-36. BIIE-0246 hydrochloride decreases the expression of p-AKT S473, P-p44/42 MAPK under the NPY-stimulated. BIIE-0246 hydrochloride reduces albuminuria in ADR nephropathy.

HY-103536A

Galnon TFA	Agonist	99.15%
Galnon TFA is a selective and non-peptide agonist of galanin GAL1 and GAL2 receptor, with K_is of 11.7 and 34.1 μM respectively. Galnon TFA exhibits anticonvulsant and anxiolytic effects.

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