P2X Receptor Antagonist

P2X Receptor Antagonists (30):

Cat. No.	Product Name	Effect	Purity

HY-136026

Camlipixant	Antagonist	99.94%
Camlipixant (BLU-5937) a potent, selective, non-competitive and orally active P2X3 homotrimeric receptor antagonist with an IC₅₀ of 25 nM against hP2X3 homotrimeric. Camlipixant shows potent anti-tussive effect and no taste alteration. Camlipixant can be used for the research of unexplained, refractory chronic cough.

HY-W033577

Tricarbonyldichlororuthenium(II) dimer	Antagonist	≥98.0%
Tricarbonyldichlororuthenium(II) dimer is a pharmacological donor of CO releasing. CO releases from Tricarbonyldichlororuthenium(II) dimer prevents gastric mucosal oxidative damage induced by ischemia/reperfusion (I/R) improving gastric blood flow (GBF), decreasing DNA oxidation and inflammatory response on systemic level.

HY-150270A

NP-1815-PX sodium	Antagonist	99.62%
NP-1815-PX sodium is a potent and selective P2X4R antagonist. NP-1815-PX sodium has anti-inflammatory activity, and can relieve pain in chronic pain models. NP-1815-PX sodium also inhibits guinea pig tracheal/bronchial smooth muscle (TSM and BSM) contractions.

HY-137451

Sivopixant	Antagonist	99.90%
Sivopixant (S-600918) is a potent and selective P2X3 receptor antagonist (P2X3 IC₅₀=4.2 nM; P2X2/3 IC₅₀=1100 nM). Sivopixant shows strong analgesic effect.

HY-14483A

AF-353 hydrochloride	Antagonist
AF-353 hydrochloride is a potent, selective and orally bioavailable P2X3/P2X2/3 receptor antagonist, with a pIC₅₀ of 8.0 for both human and rat P2X3, and with a pIC₅₀ of 7.3 for human P2X2/3.

HY-161914

P2X3 antagonist 39	Antagonist
P2X3 antagonist 39 (compound 26a) is a selective P2X3 receptor antagonist with an IC₅₀ value of 54.9 nM. P2X3 antagonist 39 can be used in the study of neuropathic pain model.

HY-123481

JNJ-42253432	Antagonist	98.15%
JNJ-42253432 is a CNS-penetrant, high-affinity and orally active P2X7 antagonist, with pK_i values of 9.1 and 7.9 for rat and human P2X7 channels, respectively.

HY-108667

TNP-ATP triethylammonium	Antagonist	98.7%
TNP-ATP triethylammonium is a selective P2X receptor antagonist. TNP-ATP triethylammonium shows antinociceptive effects in rats.

HY-108671

NF110	Antagonist
NF110 is a P2X₃ receptor antagonist (K_i = 36 nM) and inactive toward P2Y receptors stably expressed (IC₅₀s > 10 M). NF110 blocks alphabeta-methylene-ATP-induced currents (IC₅₀ = 527 nM) in rat dorsal root ganglia neurons.

HY-109173

Filapixant	Antagonist	98.78%
Filapixant is a purinoreceptor antagonist extracted from patent WO2016091776A1, example 348. Filapixant is the active reference substance of Eliapixant.

HY-137451A

(E/Z)-Sivopixant	Antagonist	98.64%
(E/Z)-Sivopixant ((E/Z)-S-600918) is a potent P2X3 receptor antagonist with an IC₅₀ of 4 nM. (E/Z)-Sivopixant can be used for respiratory diseases research.

HY-150059

P2X7 receptor antagonist-2	Antagonist	99.21%
P2X7 receptor antagonist-2 is a potent P2X7 receptor antagonist with a pIC₅₀ value of 6.5-7.5. P2X7 receptor antagonist-2 has efficacy of combating neuroinflammation.

HY-108673

Ro 0437626	Antagonist
Ro 0437626 is a selective purinergic (P2X₁) receptor antagonist (IC₅₀ = 3 μM), but shows low affinity for P2X2, P2X3 and P2X2/3 receptors (IC₅₀ > 100 μM).

HY-151546

MRS4596	Antagonist
MRS4596 is a potent and selective P2X4 receptor antagonist with an IC₅₀ value of 1.38 μM for human P2X4 receptor. MRS4596 has neuroprotective and neuro-rehabilitative activities in ischemic stroke model. MRS4596 can be used in research of ischemic stroke .

HY-143890

MRS4738	Antagonist
MRS4738 is a potent and high affinity P2Y14R antagonist. MRS4738 exhibits anti-hyperallodynic and antiasthmatic activity in vivo.

HY-101077

Iso-PPADS tetrasodium	Antagonist
Iso-PPADS tetrasodium is a P2X-purinoceptor antagonist. Iso-PPADS tetrasodium inhibits P2X1 and P2X3 receptor with IC₅₀s of 43 nM and 84 nM. Iso-PPADS tetrasodium is protective against ventilator-induced brain injury (VIBI).

HY-124300

JNJ-54166060	Antagonist
JNJ-54166060 is a potent and selective P2X7 receptor antagonist, with IC₅₀s of 4/115/72 nM for human/rat/mouse P2X7 receptor, respectively.

HY-151547

MRS4719	Antagonist
MRS4719 is a potent P2X4 receptor antagonist with an IC₅₀ value of 0.503 μM for human P2X4 receptor. MRS4719 can reduce infarct volume and reduce brain atrophy, showing neuroprotective and neuro-rehabilitative activities in ischemic stroke model. MRS4719 also reduces ATP-induced [Ca²⁺]_i influx in primary human monocyte-derived macrophages. MRS4719 can be used to research ischemic stroke.

HY-159832

Relicpixant	Antagonist
Relicpixant is a potent purinoreceptor (P2X) antagonist.

HY-143576

P2X3 antagonist 37	Antagonist
P2X3 antagonist 37 is a potent P2X3 receptor antagonist with an IC₅₀ of 32.45 nM for hP2X3 (WO2021115225A1, example 68).

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