2. Membrane Transporter/Ion Channel
  3. P2X Receptor
  4. Sivopixant

Sivopixant  (Synonyms: S-600918)

Cat. No.: HY-137451 Purity: 99.90%
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Sivopixant (S-600918) is a potent and selective P2X3 receptor antagonist (P2X3 IC50=4.2 nM; P2X2/3 IC50=1100 nM). Sivopixant shows strong analgesic effect.

For research use only. We do not sell to patients.

Sivopixant Chemical Structure

Sivopixant Chemical Structure

CAS No. : 2414285-40-6

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1 mg USD 180 In-stock
5 mg USD 450 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Sivopixant:

Sivopixant Related Antibodies

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Description

Sivopixant (S-600918) is a potent and selective P2X3 receptor antagonist (P2X3 IC50=4.2 nM; P2X2/3 IC50=1100 nM). Sivopixant shows strong analgesic effect[1].

In Vivo

Sivopixant (S-600918) (i.v.;1 mg/kg) shows a longer half-life (T1/2= 10.1 hours) and a strong analgesic effect in the rat Seltzer model of allodynia (ED50=0.4 mg/kg)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

507.93

Formula

C25H22ClN5O5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N(C1=O)C[C@H](C)C(O)=O)N/C(N1CC2=CC=C(C=C2)Cl)=N\C3=CC=C(C=C3)OC4=CC=CC=N4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (196.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9688 mL 9.8439 mL 19.6878 mL
5 mM 0.3938 mL 1.9688 mL 3.9376 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9688 mL 9.8439 mL 19.6878 mL 49.2194 mL
5 mM 0.3938 mL 1.9688 mL 3.9376 mL 9.8439 mL
10 mM 0.1969 mL 0.9844 mL 1.9688 mL 4.9219 mL
15 mM 0.1313 mL 0.6563 mL 1.3125 mL 3.2813 mL
20 mM 0.0984 mL 0.4922 mL 0.9844 mL 2.4610 mL
25 mM 0.0788 mL 0.3938 mL 0.7875 mL 1.9688 mL
30 mM 0.0656 mL 0.3281 mL 0.6563 mL 1.6406 mL
40 mM 0.0492 mL 0.2461 mL 0.4922 mL 1.2305 mL
50 mM 0.0394 mL 0.1969 mL 0.3938 mL 0.9844 mL
60 mM 0.0328 mL 0.1641 mL 0.3281 mL 0.8203 mL
80 mM 0.0246 mL 0.1230 mL 0.2461 mL 0.6152 mL
100 mM 0.0197 mL 0.0984 mL 0.1969 mL 0.4922 mL
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Sivopixant Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sivopixant2414285-40-6S-600918S600918S 600918P2X ReceptorP2XRsselectiveanalgesicsciaticnerveligationpainInhibitorinhibitorinhibit

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