2. Signaling Pathways
  3. Epigenetics
    TGF-beta/Smad
  4. PKC

PKC

Protein kinase C

PKC

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PKC (Protein kinase C) is a family of protein kinase enzymes that are involved in controlling the function of otherproteins through the phosphorylation of hydroxyl groups of serine and threonine amino acid residues on these proteins. PKC enzymes in turn are activated by signals such as increases in the concentration of diacylglycerol (DAG) or calcium ions (Ca2+). Hence PKC enzymes play important roles in several signal transduction cascades. The PKC family consists of 15 isozymes in humans: PKC-α (PRKCA), PKC-β1 (PRKCB), PKC-β2 (PRKCB), PKC-γ (PRKCG), PKC-δ (PRKCD), PKC-δ1 (PRKD1), PKC-δ2 (PRKD2), PKC-δ3 (PRKD3), PKC-ε (PRKCE), PKC-η (PRKCH), PKC-θ (PRKCQ), PKC-ι (PRKCI), PKC-ζ (PRKCZ), PK-N1 (PKN1), PK-N2 (PKN2), PK-N3 (PKN3). PKC is involved in receptor desensitization, in modulating membrane structure events, in regulating transcription, in mediating immune responses, in regulating cell growth, and in learning and memory. These functions are achieved by PKC-mediated phosphorylation of other proteins.

PKC Isoform Specific Products:

PKC Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-155619
    Protein kinase inhibitor 7
    		Inhibitor
    Protein kinase inhibitor 7 is an inhibitor for protein kinase A and protein kinase C. Protein kinase inhibitor 7 affects autocrine motility factor (AMF) signaling pathway, without affecting the cell motility.
    Protein kinase inhibitor 7
  • HY-134963
    SBI-0087702
    SBI-0087702 promots the cytoplasmic localization of ATF2 in melanoma cells. SBI-0087702-induced translocation of ATF2 to the mitochondria results in increased apoptosis due to loss of mitochondrial membrane integrity. SBI-0087702 also inhibits growth and motility of melanoma cells. SBI-0087702 was shown to inhibit ATF2 phosphorylation on Thr52 by PKCε.
    SBI-0087702
  • HY-13502S
    Mitoxantrone-d8
    		Inhibitor
    Mitoxantrone-d8 (mitozantrone-d8) is the deuterium labeled Mitoxantrone. Mitoxantrone is a topoisomerase II inhibitor and also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 μM[1][2].
    Mitoxantrone-d<sub>8</sub>
  • HY-RS11129
    Prkcg Mouse Pre-designed siRNA Set A
    		Inhibitor

    Prkcg Mouse Pre-designed siRNA Set A contains three designed siRNAs for Prkcg gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Prkcg Mouse Pre-designed siRNA Set A
    Prkcg Mouse Pre-designed siRNA Set A
  • HY-RS11130
    Prkcg Rat Pre-designed siRNA Set A
    		Inhibitor

    Prkcg Rat Pre-designed siRNA Set A contains three designed siRNAs for Prkcg gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Prkcg Rat Pre-designed siRNA Set A
    Prkcg Rat Pre-designed siRNA Set A
  • HY-N12466
    3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine
    		Inhibitor
    3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine (Compound 7) is an inhibitor of protein kinases, with IC50s of 0.092, 0.26, 0.77 μM for PKC-α, ROCK, ASK1. 3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine shows potent cytotoxicity against PC-3 cancer cells with an IC50 value of 0.16 μM.
    3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine
  • HY-N0281R
    Daphnetin (Standard)
    		Inhibitor
    Daphnetin (Standard) is the analytical standard of Daphnetin. This product is intended for research and analytical applications. Daphnetin (7,8-dihydroxycoumarin), one coumarin derivative can be found in plants of the Genus Daphne, is a potent, oral active protein kinase inhibitor, with IC50s of 7.67 μM, 9.33 μM and 25.01 μM for EGFR, PKA and PKC in vitro, respectively. Daphnetin triggers ROS-induced cell apoptosis and induces cytoprotective autophagy by modulating the AMPK/Akt/mTOR pathway. Daphnetin has anti-inflammation activitity and inhibits TNF-α, IL-1 , ROS, and MDA production. Daphnetin has schizontocidal activity against malaria parasites. Daphnetin can be used for rheumatoid arthritis , cancer and anti-malarian research.
    Daphnetin (Standard)
  • HY-156793
    hRIO2 kinase ligand-1
    		Ligand 99.95%
    hRIO2 kinase ligand-1 (com 9) is a ligand of hRIO2 kinase, with a Kd value of 520 nM.
    hRIO2 kinase ligand-1
  • HY-P10471B
    Ala-MPSD
    Ala-MPSD is a control peptide for MPSD (HY-P10471). In Ala-MPSD, the four serine residues of MPSD are substituted by alanines.
    Ala-MPSD
  • HY-RS11118
    Prkca Rat Pre-designed siRNA Set A
    		Inhibitor

    Prkca Rat Pre-designed siRNA Set A contains three designed siRNAs for Prkca gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Prkca Rat Pre-designed siRNA Set A
    Prkca Rat Pre-designed siRNA Set A
  • HY-P3816
    PKCε Inhibitor Scramble Peptide
    		Inhibitor
    PKCε Inhibitor Scramble Peptide is a scrambled peptide with identical amino acid composition to PKCε inhibitor peptide.
    PKCε Inhibitor Scramble Peptide
  • HY-112384
    Safingol
    		Inhibitor
    Safingol is a lyso-sphingolipid PKC (protein kinase C ) inhibitor.
    Safingol
  • HY-W013242R
    Gondoic acid (Standard)
    		Inhibitor
    Gondoic acid (Standard) is an analytical standard for Gondoic acid. This product is used for research and analytical applications. Gondoic acid (cis-11-Eicosenoic acid), a monounsaturated long-chain fatty acid, is contained in a variety of plant oils and nuts. Gondoic acid can exert anti-inflammatory activity by inhibiting the production of ROS and the PKCθ/ERK/STAT3 signaling pathway. Gondoic acid can be used as a raw material for medical supplies and a moisturizing ingredient in cosmetic creams.
    Gondoic acid (Standard)
  • HY-P3741
    [Ala9,10, Lys11,12] Glycogen Synthase (1-12)
    [Ala9,10, Lys11,12] Glycogen Synthase (1-12) is a selective substrate for phosphorylation by protein kinase C (PKC). [Ala9,10, Lys11,12] Glycogen Synthase (1-12) can be used to determine the activity of protein kinase C.
    [Ala9,10, Lys11,12] Glycogen Synthase (1-12)
  • HY-P1803
    Protein Kinase C Peptide Substrate
    Protein Kinase C Peptide Substrate is targeted to a specific cellular compartment in a manner dependent on second messengers and on specific adapter proteins in response to extracellular signals that activate G-protein-coupled receptors, tyrosine kinase receptors, or tyrosine kinase-coupled receptors. Protein Kinase C Peptide Substrate then regulates various physiological functions including the activation of nervous, endocrine, exocrine, inflammatory, and immune systems.
    Protein Kinase C Peptide Substrate
  • HY-P1734
    Ac-MBP (1-11)
    Ac-MBP 1-11, a short peptide sequence, is the major encephalitogenic epitope in myelin basic protein (MBP).
    Ac-MBP (1-11)
  • HY-100934
    SC-9
    		Activator
    SC-9 is a PKC activator in the presence of Ca2+.
    SC-9
  • HY-12048R
    Chelerythrine chloride (Standard)
    		Inhibitor
    Chelerythrine (chloride) (Standard) is the analytical standard of Chelerythrine (chloride). This product is intended for research and analytical applications. Chelerythrine chloride is a potent, cell-permeable inhibitor of protein kinase C, with an IC50 of 660 nM. Chelerythrine chloride inhibits the Bcl-XL-Bak BH3 peptide binding with IC50 of 1.5 μM and displaces Bax from Bcl-XL. Chelerythrine chloride induces apoptosis and autophagy.
    Chelerythrine chloride (Standard)
  • HY-164428
    AE 51310
    		Inhibitor
    AE 51310 is an OPN4 inhibitor. AE 51310 inhibits the activation of PKC and the downstream BRAF/MEK/ERKs signaling pathway. AE 51310 can be used for cancer research, such as NSCLC.
    AE 51310
  • HY-119312
    C8 Dihydroceramide
    C8 Dihydroceramide is a negative control of C8 Ceramide. C8-Ceramide (N-Octanoyl-D-erythro-sphingosine) is a cell-permeable analog of naturally occurring ceramides. C8-Ceramide has anti-proliferation properties and acts as a potent chemotherapeutic agent. C8-Ceramide stimulates dendritic cells to promote T cell responses upon virus infections. C8-Ceramide induces slight activation of protein kinase (PKC) in vitro.
    C8 Dihydroceramide
Cat. No. Product Name / Synonyms Application Reactivity
PKC Isoform Comparison

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