2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Phosphatase

Phosphatase

Phosphatase

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Phosphatases are enzyme that remove a phosphate group from a protein. Protein tyrosine phosphatases (PTPs) comprise a diverse family of transmembrane and cytoplasmic enzymes. PTPs play an important role in regulating the proliferative activity of cells and the integrity of cell-cell and cell-matrix contacts. Protein tyrosine phosphatase 1B (PTP1B) is a non-receptor PTP frequently associated with the endoplasmic reticulum and vesicles subjacent to the plasma membrane. PTP1B as a key negative regulator of leptin receptor pathways has been an attractive therapeutic target for the treatment of type 2 diabetes mellitus and obesity. Four major serine/threonine-specific protein phosphatase catalytic subunits are present in the cytoplasm of animal cells. Three of these enzymes, PP1, PP2A, and PP2B, are members of the same gene family, while PP2C appears to be distinct.The alkaline phosphatases comprise a heterogeneous group of enzymes that are widely distributed in mammalian cells. Acid phosphatase enzymes catalyze the hydrolysis of phosphate monoesters following the general equation.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-156659
    NC1
    		Inhibitor
    NC1 is a noncompetitive and allosteric lymphoid-specific tyrosine phosphatase (LYP) inhibitor, with a Ki value 4.3 μM. NC1 inhibits LYP by restricting the movement of the WPD-loop. NC1 inhibits LYP-mediated TCR signaling in T cells.
    NC1
  • HY-D2204
    SHP1-IN-1
    		Inhibitor
    SHP1-IN-1 (compound 5p) is a fluorescent probe for the protein tyrosine phosphatase SHP1 containing the Src homology 2 domain. SHP1-IN-1 has SHP1 inhibitory activity, selectivity for Fe3+ ions and good fluorescence properties. SHP1-IN-1 exhibits aggregation post-quenching (ACQ) effect, good interference immunity and low detection limit (5.55 μM).
    SHP1-IN-1
  • HY-162480
    PTP1B-IN-27
    		Inhibitor
    PTP1B-IN-27 (Compound 7i) is an inhibitor of protein tyrosine phosphatase 1-B (PTP‐1B)(IC50=8.2 µM). PTP1B-IN-27 also inhibits α-Glucosidase (IC50=120 µM) and shows competitive inhibition (Ki=118 µM).
    PTP1B-IN-27
  • HY-149865
    TPE-1p
    TPE-1p is a cascade-activated AIEgen-peptide probe. TPE-1p self-assembles in aqueous solution to exhibit bright fluorescence in response to alkaline phosphatase (ALP) and ChT-L. TPE-1p can be utilized to noninvasively assess the inhibition efficiency of a ChT-L inhibitor in cells.
    TPE-1p
  • HY-160791
    Claramine
    		Inhibitor
    Claramine is a steroid polyamine with blood-brain barrier permeability. Claramine can regulate the properties of lipid membranes and protect cells from various biological toxins, including misfolded protein oligomers and biological protein-based toxins.
    Claramine
  • HY-B0537BR
    Pentamidine (isethionate) (Standard)
    		Inhibitor
    Pentamidine (isethionate) (Standard) is the analytical standard of Pentamidine (isethionate). This product is intended for research and analytical applications. Pentamidine isethionate (MP-601205 isethionate) is an antimicrobial agent and interferes with DNA biosynthetics. Pentamidine isethionate inhibits parasite Leishmania infantum with an IC50 of 2.5 μM. Pentamidine isethionate is a potent and selective protein tyrosine phosphatases (PTPases) and phosphatase of regenerating liver (PRL) inhibitor. Pentamidine isethionate has the potential for Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia treatment. Antitumor and antibacterial activities.
    Pentamidine (isethionate) (Standard)
  • HY-162428
    PTPN2/1-IN-3
    		Inhibitor
    PTPN2/1-IN-3 (compound 4) is a modified, orally active PTPN2/N1 inhibitor based on ABBV-CLS-484 (HY-145923). PTPN2/1-IN-3 has anti-tumor effects, inhibiting PTPN2 with an IC50 of 9.3 nM and having an oral bioavailability of 93% in mice.
    PTPN2/1-IN-3
  • HY-105656
    Hydrocortisone phosphate sodium
    		Substrate 99.11%
    Hydrocortisone phosphate sodium is a soft steroid with low anti-inflammatory properties and a short duration of action. Hydrocortisone phosphate sodium can be used for the research for several ocular conditions and gastric ulcers.
    Hydrocortisone phosphate sodium
  • HY-153938
    PROTAC PTPN2 degrader-2
    PROTAC PTPN2 degrader-2 (example 187B) is a potent PTPN2 degrader with potential for studying cancer or metabolic diseases.
    PROTAC PTPN2 degrader-2
  • HY-113612
    Cytostatin
    		Inhibitor
    Cytostatin is an effective and selective protein phosphatase 2A (PP2A) inhibitor with an IC50 value of 210 nM. Cytostatin exhibits anti-metastatic properties, good antitumor activity, and can induce apoptosis. Cytostatin can also prevent the adhesion of B16 melanoma cells to components of the extracellular matrix (laminin and collagen). Cytostatin belongs to the family of natural product fosriecin.
    Cytostatin
  • HY-D0850R
    Tartaric acid disodium dihydrate (Standard)
    		Inhibitor
    Tartaric acid (disodium dihydrate) (Standard) is the analytical standard of Tartaric acid (disodium dihydrate). This product is intended for research and analytical applications. Tartaric acid disodium dehydrate (L-(+) -tartaric acid) is an orally active weak organic acid that can be isolated from grapes. Tartaric acid disodium dehydrate has vasodilatory and antihypertensive effects. Tartaric acid disodium dehydrate can be used as flavorings and antioxidants in a range of foods and beverages. Tartaric acid disodium dehydrate can be used in laser frequency doubling and optical limiting applications[4].
    Tartaric acid disodium dihydrate (Standard)
  • HY-159694A
    IONIS PTP1BRx sodium
    		Inhibitor
    IONIS PTP1BRx (ISIS 404173) sodium is an antisense inhibitor of protein tyrosine phosphatase 1B (PTP-1B). IONIS PTP1BRx sodium shows antidiabetic activity, and can be used for the study of insulin resistance and type 2 diabetes mellitus associated with obesity.
    IONIS PTP1BRx sodium
  • HY-P990268
    Anti-Mouse CD45.2 Antibody (104.2)
    Anti-Mouse CD45.2 Antibody (104.2) is a mouse-derived IgG2a, κ type antibody inhibitor, targeting to mouse CD45.2.
    Anti-Mouse CD45.2 Antibody (104.2)
  • HY-128024
    VHR-IN-1
    		Inhibitor
    VHR-IN-1 (Compound SA1) is a potent and selective VHR phosphatase inhibitor with an IC50 of 18 nM. VHR-IN-1 can inhibit the proliferation of cervix cancer cells and has anti-tumor activity.
    VHR-IN-1
  • HY-117830
    CX08005
    		Inhibitor
    CX08005 is a competitive PTP1B inhibitor. CX08005 can directly enhance the action of insulin in vivo and in vitro and improve insulin resistance.
    CX08005
  • HY-141524
    RMC-3943
    		Inhibitor
    RMC-3943 is an allosteric SHP2 inhibitor (inhibition of full-length SHP2 in biochemical assay, IC50 = 2.19 nM).
    RMC-3943
  • HY-P5447
    RRLIEDAEpYAARG
    RRLIEDAEpYAARG is a biological active peptide. (Phosphatase substrate.)
    RRLIEDAEpYAARG
  • HY-P1799A
    [pTyr5] EGFR (988-993) (TFA)
    [pTyr5] EGFR (988-993) TFA is derived from the autophosphorylation site (Tyr992) of epidermal growth factor receptor (EGFR 988-993). [pTyr5] EGFR (988-993) TFA is often complexed with the catalytically inactive protein-tyrosine phosphate 1B (PTP1B).
    [pTyr5] EGFR (988-993) (TFA)
  • HY-N15231
    Dipsacus saponin XII
    		Activator
    Dipsacus saponin XII (compound 6) is a triterpenoid saponin that stimulates the proliferation of UMR106 cells and increases alkaline phosphatase activity in UMR106 cells (4 μM).
    Dipsacus saponin XII
  • HY-101047S1
    D-erythro-Sphingosine-13C2,d2
    		Activator
    D-erythro-Sphingosine-13C2,d2 is a deuterated labeled D-erythro-Sphingosine. D-erythro-Sphingosine (Erythrosphingosine) is a very potent activator of p32-kinase with an EC50 of 8 μM, and inhibits protein kinase C (PKC). D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator.
    D-erythro-Sphingosine-<sup>13</sup>C<sub>2</sub>,d<sub>2</sub>
Cat. No. Product Name / Synonyms Species Source
Cat. No. Product Name / Synonyms Application Reactivity