2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Phospholipase
  5. Phospholipase Isoform

Phospholipase

 

Phospholipase Related Products (169):

Cat. No. Product Name Effect Purity
  • HY-138871
    cPLA2α-IN-derivative 1
    		Control
    cPLA2α-IN-derivative 1 is an inactive alcohol derivative of a highly potent Cytosolic phospholipase A2α (cPLA2α) inhibitor.
  • HY-155343
    A4333
    		Inhibitor
    A4333 is biotinylated compound of A3373 (HY-155342) that inhibits Phospholipase D1 (PLD1), but not PLD2. A4333 plays an important role in antitumor activity.
  • HY-153561A
    Lp-PLA2-IN-16
    		Inhibitor
    Lp-PLA2-IN-16 (example 1) is a lipoprotein-associated phospholipase A2 (Lp-PLA 2) inhibitor, which can be used in the research of Alzheimer's disease, etc.
  • HY-B0470R
    Neomycin (sulfate) (Standard)
    		Inhibitor
    Neomycin (sulfate) (Standard) is the analytical standard of Neomycin (sulfate). This product is intended for research and analytical applications. Neomycin sulfate, an aminoglycoside antibiotic, exerts antibacterial activity through irreversible binding of the nuclear 30S ribosomal subunit, thereby blocking bacterial protein synthesis. Neomycin sulfate is a known phospholipase C (PLC) inhibitor. Neomycin sulfate potently inhibits both nuclear translocation of angiogenin and angiogenin-induced cell proliferation and angiogenesis.
  • HY-N0134R
    Tanshinone I (Standard)
    		Inhibitor
    Tanshinone I (Standard) is the analytical standard of Tanshinone I. This product is intended for research and analytical applications. Tanshinone I is an inhibitor of type IIA human recombinant sPLA2 (IC50=11 μM) and rabbit recombinant cPLA2 (IC50=82 μM).
  • HY-19151C
    Fuzapladib calcium
    		Inhibitor
    Fuzapladib calcium, an orally active leukocyte-function-associated antigen type 1 (LFA-1) activation inhibitor, is a leukocyte adhesion molecule. Fuzapladib calcium is also a phospholipase A2 (PLA2) inhibitor. Fuzapladib calcium exerts anti-inflammatory effects by inhibiting leukocyte migration into the inflammatory site.
  • HY-23909
    7,7-Dimethyl-(5Z,8Z)-eicosadienoic acid
    		Inhibitor
    7,7-Dimethyl-(5Z,8Z)-eicosadienoic acid (DEDA), a phospholipase inhibitor, is a non-metabolizable analog of arachidonic or eicosadienoic acid. 7,7-Dimethyl-(5Z,8Z)-eicosadienoic acid (DEDA) inhibits P388D1 cell phospholipase A2 (PLA2) (IC50 = 16 µM) and snake venom PLA2 (IC50 = 14 µM).
  • HY-138990
    GK563
    		Inhibitor
    GK563 is a selective Ca2+-independent phospholipase A2 (GVIA iPLA2) inhibitor with an IC50 value of 1 nM. GK563 is 22000 times more active against GVIA iPLA2 than GIVA cPLA2. GK563 reduces β-cell apoptosis induced by proinflammatory cytokines, raising the possibility that it can be beneficial in countering autoimmune diseases, such as type 1 diabetes.
  • HY-19041
    CGP-35949 sodium
    		Inhibitor
    CGP-35949 sodium is a LTD4 antagonist with phospholipase inhibitory activity. CGP-35949 sodium can be used for research of asthma.
  • HY-W396889
    (R)-N-(1-Hydroxypropan-2-yl)palmitamide
    		Inhibitor
    (R)-N-(1-Hydroxypropan-2-yl)palmitamide (compound 24) is a substrate analog inhibitor of phospholipase A2.
  • HY-17485R
    Alminoprofen (Standard)
    		Inhibitor
    Alminoprofen (Standard) is the analytical standard of Alminoprofen. This product is intended for research and analytical applications. Alminoprofen (EB-382) is a nonsteroidal anti-inflammatory agent (NSAID) of the phenylpropionic acid class. Alminoprofen possesses a dual anti-inflammatory action, by inhibiting both secretory phospholipase A2 (sPLA2) and COX-2.
  • HY-136177R
    Tris(2,4-di-tert-butylphenyl)phosphate (Standard)
    		Inhibitor
    Tris(2,4-di-tert-butylphenyl)phosphate (Standard) is the analytical standard of Tris(2,4-di-tert-butylphenyl)phosphate. This product is intended for research and analytical applications. Tris(2,4-di-tert-butylphenyl)phosphate is an active compound from the leaves of Vitex negundo L. shows anti-inflammatory activity with evidence of inhibition for secretory Phospholipase A2 (sPLA2) through molecular docking.
  • HY-19920
    AVX001
    		Inhibitor
    AVX001 is an inhibitor of phospholipase A2 (cPLA2α) that can be used in the research of psoriasis.
  • HY-171033
    ASM-IN-3
    		Inhibitor
    ASM-IN-3 (Compound 21b) is a selective and BBB-penetrating acid sphingomyelinase (ASM) inhibitor (IC50: 3.37 μM for pure human ASM). ASM-IN-3 improves depression-like behaviors by inhibiting ASM activity and increasing neurogenesis in hippocampus in Reserpine (HY-N0480)-induced depressed rats.
  • HY-18570R
    1-Naphthaleneacetic acid (Standard)
    		Inhibitor
    1-Naphthaleneacetic acid (Standard) is the analytical standard of 1-Naphthaleneacetic acid. This product is intended for research and analytical applications. 1-Naphthaleneacetic acid (1-Naphthylacetic acid), a auxin, can promote plant growth. 1-Naphthaleneacetic acid is also an inhibitor of PLA2, with an IC50 of 13.16 μM.
  • HY-170650
    SMase-IN-1
    		Inhibitor
    SMase-IN-1 (Compound 4) is a bacterial sphingomyelinase enzyme (SMase) inhibitor (IC50 value for B. cereus SMase is 6.43 µM). SMase-IN-1 also inhibits eqBuChE (59.50% inhibition rate at 50 µM concentration). SMase-IN-1 forms a complex with Cu2+ in biometal interactions. SMase-IN-1 reduces B. cereus-induced hemolysis on sheep erythrocytes.
  • HY-116273
    ML299
    		Inhibitor
    ML299 is a selective allosteric modulator and a dual inhibitor of phospholipases D1 and D2 (IC50 values are 6 and 12 nM, respectively). ML299 decreases invasive migration in U87-MG glioblastoma cells.
  • HY-P10658
    ARF1 (2-17)
    		Inhibitor
    ARF1 (2-17) inhibits both ARF-independent (PLC-β) and ARF-dependent (PLD) pathways. ARF1 (2-17) inhibits GTP-γ-S-stimulated PLD activity, phospholipase C-β (PLC-β), and exocytosis.
  • HY-17569R
    Difluprednate (Standard)
    		Inhibitor
    Difluprednate (Standard) is the analytical standard of Difluprednate. This product is intended for research and analytical applications. Difluprednate is a topical corticosteroid, which is thought to act by the induction of phospholipase A2 inhibitory proteins (lipocortins). Difluprednate is used for the symptomatic treatment of inflammation and pain associated with ocular surgery.
  • HY-115855
    Ro 31-4639
    		Inhibitor
    Ro 31-4639 is a potent phospholipase A2 inhibitor with an IC50 of 1.5 μM.