Prostaglandin Receptor Inhibitor

Prostaglandin Receptor Inhibitors (64):

Cat. No.	Product Name	Effect	Purity

HY-124192

Amogastrin	Inhibitor
Amogastrin is a tetrapeptide that stimulates gastric extraction of ^99mTc pertechnetate. Amogastrin can be used for the research of gastric mucosal disease imaging. Amogastrin stimulates the production of prostate hormones.

HY-B1074

Ethamsylate	Inhibitor	99.49%
Ethamsylate (Etamsylate) is an orally active anti-hemorrhagic compound. Ethamsylate inhibits biosynthesis and action of prostaglandins. Ethamsylate has the potential to maintain early hemostasis as well as restores capillary resistance. Ethamsylate acts as an antiangiogenic factor, inhibiting wound healing and matrigel tubulogenesis..

HY-15342A

Timapiprant sodium	Inhibitor	99.61%
Timapiprant sodium (OC000459 sodium) is a potent, selective, and orally active D prostanoid receptor 2 (DP₂, also known as CRTH2) antagonist. Timapiprant sodium (OC000459 sodium) potently displaces [³H] PGD2 from human recombinant DP₂ (K_i=13 nM), rat recombinant DP₂ (K_i=3 nM), and human native DP₂ (K_i=4 nM). Timapiprant sodium (OC000459 sodium) inhibits mast cell activation of Th2 lymphocytes and eosinophils.

HY-130223

11β-Prostaglandin E2	Inhibitor	≥99.0%
11β-Prostaglandin E2 (11β-Dinoprostone), a Prostanoid derivative, inhibits [^3H]PGE₂ binding to hypothalamic membranes in the rat with a K_i of 53.3 nM.

HY-107795

Benorilate	Inhibitor	99.85%
Benorylate (Salipran) is the esterification product of paracetamol and acetylsalicylic acid. Benorylate has anti-inflammatory, analgesic and antipyretic properties. Benorylate could also inhibit prostaglandin (PG) synthesis.

HY-101813

Laflunimus	Inhibitor	99.76%
Laflunimus (HR325) is an immunosuppressive agent and an analogue of the Leflunomide-active metabolite A77 1726. Laflunimus is an orally active inhibitor of dihydroorotate dehydrogenase (DHODH). Laflunimus suppresses immunoglobulin (Ig) secretion, with IC₅₀ values of 2.5 and 2 µM for IgM and IgG, respectively. Laflunimus also is a prostaglandin endoperoxide H synthase (PGHS) -1 and -2 inhibitor.

HY-138665

HHS-0701	Inhibitor	98.90%
HHS-0701, a sulfur-triazole exchange (SuTEx) ligand, is a potent tyrosine-reactive prostaglandin reductase 2 (PTGR2) inhibitor. HHS-0701 blocks PTGR2 metabolism of the lipid substrate 15-Keto-PGE2.

HY-106080A

Furegrelate sodium	Inhibitor	99.82%
Furegrelate Sodium (U-63557A) is a potent, orally available, and selective thromboxane synthase inhibitor. Furegrelate Sodium inhibits human platelet microsomal thromboxane A2 (TxA2) synthase with an IC₅₀ of 15 nM. Furegrelate Sodium is being developed as an antiplatelet agent.

HY-114564

Satigrel	Inhibitor	99.85%
Satigrel (E5510) is a potent inhibitor of platelet aggregation. Satigrel inhibits collagen- and arachidonic acid-induced platelet aggregation through preventing thromboxane A2 synthesis by selective inhibition of the target enzyme, PGHS1, which exists in platelets. Satigrel inhibits PGHS1 (IC₅₀: 0.081 μM) and PGHS2 (IC₅₀: 5.9 μM). Satigrel is against Type III PDE, Type V and Type II (IC₅₀: 15.7 μM, 39.8 μM and 62.4 μM, respectively).

HY-101438

Darbufelone	Inhibitor	≥98.0%
Darbufelone is a dual inhibitor of cellular PGF_2α and LTB₄ production. Darbufelone potently inhibits PGHS-2 (IC₅₀= 0.19 μM) but is much less potent with PGHS-1 (IC₅₀=20 μM).

HY-Z7721

(Rac)-Beraprost sodium	Inhibitor
(Rac)-Beraprost ((Rac)-ML 1129) sodium is a racemic isomer of Beraprost sodium (HY-13569A). Beraprost sodium is an orally active prostacyclin analog that inhibits the release of Ca²⁺ from intracellular storage sites by binding to prostacyclin membrane receptors (Prostaglandin Receptor), leading to relaxation of smooth muscle cells and vasodilation. Beraprost sodium has vasodilatory, antiplatelet, and cytoprotective effects, making it promising for research in the field of cardiovascular diseases, such as thromboangiitis obliterans and atherosclerosis.

HY-108308

Ibuprofen guaiacol ester	Inhibitor	98.49%
Ibuprofen guaiacol ester (AF 2259; Metoxibutropate) is a potent and orally active prostaglandin synthesis inhibitor. Ibuprofen guaiacol ester has the potential for the research of edema and fever.

HY-17350

Anitrazafen	Inhibitor
Anitrazafen is a topically effective antiinflammatory agent.

HY-129639

L11204	Inhibitor
L11204 (DL-204-IT) is a potent inhibitor of prostaglandin metabolism. L11204 inhibits PMS-induced superovulation and reduced the number of recoverable ova in the oviducts of hamsters. L11204 also inhibits chorionic gonadotrophin-induced ovarian hypertrophy and steroidogenesi in rats. L11204 is promising for research of reproductive system disorders.

HY-106874B

rel-Delequamine	Inhibitor
rel-Delequamine (rel-RS-15385-197) is an orally active, brain-penetrant, potent and selective M₂-adrenoceptor antagonist and α₂-adrenoceptor antagonist. rel-Delequamine has a pK_i of 9.45 for α₂-adrenoceptors in the rat cortex. rel-Delequamine augments K⁺-evoked release of noradrenaline with an EC₅₀ of 1 nM.

HY-165046

1,2,3-Trilinoelaidoyl glycerol	Inhibitor
1,2,3-Trilinoelaidoyl glycerol (TG(18:2(9E,12E)/18:2(9E,12E)/18:2(9E,12E))) is a compound that affects dietary triolein and has an effect on the fatty acid composition of rat organs, prostaglandin biosynthesis and platelet function. Different doses of intake have different effects on related physiological parameters of rats.

HY-106080

Furegrelate	Inhibitor
Furegrelate (U-63557A free acid) is a potent, orally available, and selective thromboxane synthase inhibitor. Furegrelate inhibits human platelet microsomal thromboxane A2 (TxA2) synthase with an IC₅₀ of 15 nM. Furegrelate is being developed as an antiplatelet agent.

HY-133079

Ascorbyl tetra-2-hexyldecanoate	Inhibitor	≥98.0%
Ascorbyl tetra-2-hexyldecanoate (tetra-isopalmitoyl Ascorbic acid; IPAA) is a lipophilic derivative of vitamin C (L-ascorbic acid). Ascorbyl tetra-2-hexyldecanoate (100 μM ) can prevent the decrease in viability of HaCaT keratinocytes induced by UVB, hydrogen peroxide, or tert-butyl hydroperoxide, and reduce the production of IL-1α and prostaglandin E2 (PGE2). Topical application of ascorbyl tetra-2-hexyldecanoate (1%) increases epidermal viability thickness, stratum corneum water content, and skin smoothness, and reduces skin roughness in hairless mice. Ascorbyl tetra-2-hexyldecanoate can be used to develop skin whitening agents in the beauty industry.

HY-W009706B

Alclofenac (lysinate)	Inhibitor
Alclofenac lysinate is a non-steroidal anti-inflammatory agent (NSAID). Alclofenac lysinate is a prostaglandin H2 synthase inhibitor. Alclofenac lysinate can be used for rheumatoid arthritis, degenerative joint disease and ankylosing spondylitis research.

HY-N11566

(+)-Oxypeucedanin methanolate	Inhibitor
(+)-Oxypeucedanin methanolate (compound 9) is a natural compound with inhibitory effect on prostaglandin E2 production.

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