Proteasome

Related Products

Proteasomes are very large protein complexes inside all eukaryotes and archaea, and in some bacteria. In eukaryotes, they are located in the nucleus and the cytoplasm. The main function of the proteasome is to degrade unneeded or damaged proteins by proteolysis, a chemical reaction that breaks peptide bonds. Enzymes that carry out such reactions are called proteases. Proteasomes are part of a major mechanism by which cells regulate the concentration of particular proteins and degrade misfolded proteins. The degradation process yields peptides of about seven to eight amino acids long, which can then be further degraded into amino acids and used in synthesizing new proteins. Proteins are tagged for degradation with a small protein called ubiquitin. The tagging reaction is catalyzed by enzymes called ubiquitin ligases. Once a protein is tagged with a single ubiquitin molecule, this is a signal to other ligases to attach additional ubiquitin molecules. The result is a polyubiquitin chain that is bound by the proteasome, allowing it to degrade the tagged protein.

Proteasome Related Products (171)
Antibodies (21)

By Effects:	Inhibitors (134) Degrader (1) Activators (8) Modulator (1)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-N11621

Sadopeptins B	Inhibitor
Sadopeptins B is a nature product that could be isolated from Streptomyces sp. Sadopeptins B is a potent proteasome inhibitor.

HY-P1081A

Acetyl-Calpastatin(184-210)(human) TFA	Inhibitor
Acetyl-Calpastatin(184-210)(human) TFA is a potent, selective and reversible calpain inhibitor with K_i values of 0.2 nM and 6 μM for µ-calpain and cathepsin L, respectively.

HY-168048

ZINC09518833	Inhibitor
ZINC09518833 is a α-ketoamide nonpeptidic proteasome inhibitor with an IC₅₀ value of 12.4 μM. ZINC09518833 binds both primed and nonprimed sites of the proteasome. ZINC09518833 is promising for research of multiple myeloma (MM).

HY-P3690

Ac-Leu-Leu-Norleucinol	Inhibitor
Ac-Leu-Leu-Norleucinol (ALLN) is a calpain inhibitor, can be used for research of Acetaminophen (HY-66005) induced acute liver damage, and lowers glutamic-oxalacetic transaminease (ALT) and glutamic-pyruvic transaminase (AST).

HY-P5379

Calpastatin subdomain B
Calpastatin subdomain B is a biological active peptide. (inhibit calpain activity)

HY-163770

Anticancer agent 233	Inhibitor
Anticancer agent 233 (compound 5g) is a 3,5-bis(arylmethylene)-4-piperidinone derivative with anticancer activity, with GI₅₀ of 0.25 and 0.23 μM for cervical cancer (HeLa) and colon cancer (HCT116) cell lines, respectively. The chlorine atom on the aromatic ring of Anticancer agent 233 interacts well with the catalytic site of 20S proteasome, inhibiting the activity of 20S proteasome to exert its anticancer effect.

HY-158412

BT317	Inhibitor
BT317 is a blood-brain transmissible mitochondrial Lon peptidase I (LonP1) and CT-L proteasome inhibitor. BT317 can increase the production of reactive oxygen species (ROS) and induce apoptosis in astrocytoma cells. BT317 has antitumor activity.

HY-137286

Z-Leu-Leu-Glu-βNA
Z-Leu-Leu-Glu-βNA (Z-Leu-Leu-Glu-β-naphthylamide) is a substrate for determination of the glutamylpeptidyl-peptide hydrolase activity of the 20S proteasome.

HY-113221AS

Isovalerylcarnitine-d₃ chloride
Isovalerylcarnitine-d₃ (chloride) is the deuterium labeled Isovalerylcarnitine chloride[1].

HY-150591

20S Proteasome-IN-3	Inhibitor
20S Proteasome-IN-3 is a 20S proteasome β5 subunit inhibitor (IC₅₀=1.64 μM). 20S Proteasome-IN-3 shows anti-tumor proliferation activity.

HY-158150

20S Proteasome-IN-5	Inhibitor
20S Proteasome-IN-5 (Compound 5) is a macrocyclic inhibitor of the 20S Proteasome, with IC₅₀ values of 0.19 and 52.5 μM for ChT-L and PGPH-L activity, respectively.

HY-157035

Proteasome β2c/i-IN-1	Inhibitor
Proteasome β2c/i-IN-1 (compound 37) is a subunit-selective human proteasome β2c and β2i inhibitor .

HY-115753

Calpain Inhibitor-1	Inhibitor
Calpain Inhibitor-1 (compound 36) is a potent and selective cysteine protease calpain 1 (Cal1) inhibitor (IC₅₀=100 nM; K_i=2.89 μM).

HY-138096

Z-LLF-CHO	Inhibitor
Z-LLF-CHO (Z-Leu-Leu-Phe-CHO) is a potent inhibitor of the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex (K_i = 460 nM). Z-LLF-CHO is also a NF-κB nuclear translocation inhibitor.

HY-157212

PARP-1/Proteasome-IN-1	Inhibitor
PARP-1/Proteasome-IN-1 (compound 42i) is a dual PARP-1 and proteasome inhibitor with significant inhibitory effects on breast cancer. PARP-1/Proteasome-IN-1 can downregulate the expression of BRCA1 and RAD51 to inhibit homologous recombination repair function and induce apoptosis.

HY-N2166A

Tomatine hydrochloride	Inhibitor
Tomatine hydrochloride is a glycoalkaloid, found in the tomato plant (Lycopersicon esculentum Mill.). Tomatine hydrochloride elicits neurotoxicity in RIP1 kinase and caspase-independent manner. Tomatine hydrochloride promotes the upregulation of nuclear apoptosis inducing factor (AIF) in neuroblastoma cells. Tomatine hydrochloride also inhibits 20S proteasome activity.

HY-108549

clasto-Lactacystin β-lactone	Inhibitor
Clasto-Lactacystin β-lactone, a natural active metabolite of lactacystin, which is a metabolite of Streptomyces, acts as an irreversible 20S proteasome inhibitor.

HY-P4284

Z-GGF-CMK	Inhibitor
Z-GGF-CMK is a protease inhibitor, inhibits ClpP1P2 and proteasome. Z-GGF-CMK exhibits cytotoxic activity against HepG2 cells with a CC₅₀ value of 125 μM.

HY-156605

Davelizomib	Inhibitor
Davelizomib is proteasome inhibitor with antineoplastic effect.

HY-157032

Proteasome-IN-5	Inhibitor
Proteasome-IN-5 (compound 5) is a proteasome inhibitor.

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Proteasome

Proteasome

Proteasome Related Products (171)

Antibodies (21)

Proteasome Related Products (171):