VTP-27999 Hydrochloride

Cat. No.: HY-76652 Purity: 98.18%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

VTP-27999 Hcl is an alkyl amine Renin inhibitor; VTP-27999 is useful for Hypertension and End-Organ Diseases.

For research use only. We do not sell to patients.

VTP-27999 Hydrochloride Chemical Structure

CAS No. : 1264191-73-2

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	USD 159	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	USD 159	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 129	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 200	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 640	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 1020	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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This product is a controlled substance and not for sale in your territory.

Other Forms of VTP-27999 Hydrochloride:

VTP-27999 TFA In-stock
VTP-27999 Get quote

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Biological Activity
Purity & Documentation
References
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Description

VTP-27999 Hcl is an alkyl amine Renin inhibitor; VTP-27999 is useful for Hypertension and End-Organ Diseases. IC50 value: Target: Renin

Clinical Trial

Molecular Weight

561.54

Formula

C₂₆H₄₂Cl₂N₄O₅

CAS No.

1264191-73-2

Appearance

Solid

Color

White to yellow

SMILES

O=C(NC[C@H](C[C@@H]1COCCC1)NC)N(CCC2)C[C@]2([H])[C@](OCCNC(OC)=O)([H])C3=CC(Cl)=CC=C3.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : ≥ 100 mg/mL (178.08 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7808 mL	8.9041 mL	17.8082 mL
5 mM	0.3562 mL	1.7808 mL	3.5616 mL
10 mM	0.1781 mL	0.8904 mL	1.7808 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 98.18%

Select Batch:

Data Sheet (271 KB) SDS (252 KB)

COA (250 KB) LCMS (90 KB)

Handling Instructions (2659 KB)

References

[1]. Lanqi Jia et al. Discovery of VTP-27999, an Alkyl Amine Renin Inhibitor with Potential for Clinical Utility ACS Med. Chem. Lett., 2011, 2 (10), pp 747-751

[2]. New renin inhibitor VTP-27999 alters renin immunoreactivity and does not unfold prorenin. Hypertension. 2013 May;61(5):1075-1082. [Content Brief]

[3]. Ishchenko A, et al. Structure-based design technology contour and its application to the design of Renin inhibitors.J Chem Inf Model. 2012 Aug 27;52(8):2089-97. Epub 2012 Jul 25. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	1.7808 mL	8.9041 mL	17.8082 mL	44.5204 mL
	5 mM	0.3562 mL	1.7808 mL	3.5616 mL	8.9041 mL
	10 mM	0.1781 mL	0.8904 mL	1.7808 mL	4.4520 mL
	15 mM	0.1187 mL	0.5936 mL	1.1872 mL	2.9680 mL
	20 mM	0.0890 mL	0.4452 mL	0.8904 mL	2.2260 mL
	25 mM	0.0712 mL	0.3562 mL	0.7123 mL	1.7808 mL
	30 mM	0.0594 mL	0.2968 mL	0.5936 mL	1.4840 mL
	40 mM	0.0445 mL	0.2226 mL	0.4452 mL	1.1130 mL
	50 mM	0.0356 mL	0.1781 mL	0.3562 mL	0.8904 mL
	60 mM	0.0297 mL	0.1484 mL	0.2968 mL	0.7420 mL
	80 mM	0.0223 mL	0.1113 mL	0.2226 mL	0.5565 mL
	100 mM	0.0178 mL	0.0890 mL	0.1781 mL	0.4452 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.