2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Renin

Renin

Renin

Related Products

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Renin is a monospecific enzyme that catalyzes the rate-limiting step in the synthesis of angiotensin II. Amplified enzymatic activity and additional physiological effects occur when renin and pro-renin bind to the (pro)renin receptor. The classical site of renin expression and secretion is the renal juxtaglomerular cell, where its expression is tightly regulated by physiological cues.

Prorenin and renin bound to the (pro)renin receptor not only increase the catalytic conversion of angiotensinogen to angiotensin I (Ang I), but also upregulate the expression of profibrotic genes. Renin plays a critical role in the regulation of blood pressure, electrolyte homeostasis, mammalian renal development, and progression of fibrotic/hypertrophic diseases. Renin inhibitors represent an alternative to angiotensin-converting enzyme inhibitors (ACEI) for the treatment of hypertension.

Renin Related Products (49):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-129714
    EMD 52297
    		Inhibitor
    EMD 52297 is a Renin inhibitor, with acute hemodynamic and hormonal effects. EMD 52297 also acts as an ACE inhibitor.
    EMD 52297
  • HY-129607
    A-65317
    		Inhibitor
    A-65317 is a primate-selective renin dipeptide inhibitor (IC50 of 0.37 nM) with long hypotensive response.
    A-65317
  • HY-136676
    Cgp 38560 methanesulfonate
    		Inhibitor
    Cgp 38560 methanesulfonate is a well-tolerated renin inhibitor. Cgp 38560 methanesulfonate caused a dose-dependent decrease in angiotensin II and plasma renin activity, and a dose-dependent increase in active renin.
    Cgp 38560 methanesulfonate
  • HY-120756
    PD125754
    		Inhibitor
    PD125754 is an oligopeptide renin inhibitor (IC50: 22 nM).
    PD125754
  • HY-123415
    PD 134922
    		Inhibitor
    PD 134922 is a potent renin and HIV-1 protease inhibitor with an IC50 of 15 nM against HIV-1 protease.
    PD 134922
  • HY-117913
    ES-8891
    ES-8891 is a renin inhibitor. Oral administration of ES-8891 to normotensive sodium-depleted macaques for one week significantly reduced plasma renin activity, immunoreactive renin concentrations, and plasma angiotensin I concentrations, while mean blood pressure decreased significantly, without significant changes in heart rate. ES-8891 regulates blood pressure by inhibiting plasma renin levels and renal renin synthesis.
    ES-8891
  • HY-120586
    SC-46944
    		Inhibitor
    SC-46944 is an orally active renin inhibitor and can be used for study of hypertension.
    SC-46944
  • HY-125625
    ES 6864
    		Inhibitor
    ES 6864 is an orally active, competitive inhibitor for human renin, with an IC50 of 6.9 nM and a Ki of 7.3 nM. ES 6864 exhibits high species-specific and enzyme-specific properties. ES 6864 exhibits metabolic stability in rat tissue homogenates. ES 6864 reduces blood pressure in rats and sodium-depleted awake marmosets.
    ES 6864
  • HY-U00262
    ACT 178882
    		Inhibitor
    ACT 178882 is a new Renin inhibitor with an IC50 of 1.4 nM.
    ACT 178882