2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Renin

Renin

Renin

Related Products

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Renin is a monospecific enzyme that catalyzes the rate-limiting step in the synthesis of angiotensin II. Amplified enzymatic activity and additional physiological effects occur when renin and pro-renin bind to the (pro)renin receptor. The classical site of renin expression and secretion is the renal juxtaglomerular cell, where its expression is tightly regulated by physiological cues.

Prorenin and renin bound to the (pro)renin receptor not only increase the catalytic conversion of angiotensinogen to angiotensin I (Ang I), but also upregulate the expression of profibrotic genes. Renin plays a critical role in the regulation of blood pressure, electrolyte homeostasis, mammalian renal development, and progression of fibrotic/hypertrophic diseases. Renin inhibitors represent an alternative to angiotensin-converting enzyme inhibitors (ACEI) for the treatment of hypertension.

Renin Related Products (55):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-120455
    PD 125967
    		Inhibitor
    PD 125967 is an oligopeptide renin inhibitor. PD 125967 can be used to low blood pressure.
    PD 125967
  • HY-A0184
    Remikiren
    		Inhibitor
    Remikiren (Ro 42-5892) is an orally active and highly specific renin inhibitor. Remikiren specifically inhibits human reninand human plasma renin with IC50 values of 0.7 and 0.8 nM, respectively. Remikiren also reduces mean arterial blood pressure in sodium-depleted marmosets and squirrel monkeys. Remikiren can be used in study of hypertension.
    Remikiren
  • HY-P5976
    Suc-Arg-Pro-Phe-His-Leu-Leu-Val-Tyr-AMC
    Suc-Arg-Pro-Phe-His-Leu-Leu-Val-Tyr-AMC (Renin Substrate I) is a renin substrate
    Suc-Arg-Pro-Phe-His-Leu-Leu-Val-Tyr-AMC
  • HY-12176R
    Aliskiren (Standard)
    		Inhibitor
    Aliskiren (Standard) is the analytical standard of Aliskiren. This product is intended for research and analytical applications. Aliskiren is an orally active, highly potent and selective renin inhibitor, with IC50 of 1.5 nM. Aliskiren can be used for the research of hypertension, cardiovascular diseases and cancer cachexia.
    Aliskiren (Standard)
  • HY-19145
    PD-134672
    		Inhibitor
    PD-134672 (CI-992) is a renin inhibitor containing a 2-amino-4-thiazolyl substituent. PD-134672 potently inhibits monkey renin in vitro and only weakly inhibits the related aspartic protease bovine feline hepsin D. The compound exhibits oral hypotensive activity in hyperreninemic normotensive monkeys. Based on its superior efficacy and long-lasting effects in vitro and in the normotensive macaque model, PD-134672 was selected for further evaluation in renal hypertensive monkeys.
    PD-134672
  • HY-P2060
    CGP 44099
    		Inhibitor
    CGP 44099 is a renin inhibitor. CGP 44099 can be used to study the ischemic injury and reperfusion arrhythmias in rat hearts.
    CGP 44099
  • HY-129714
    EMD 52297
    		Inhibitor
    EMD 52297 is a Renin inhibitor, with acute hemodynamic and hormonal effects. EMD 52297 also acts as an ACE inhibitor.
    EMD 52297
  • HY-129607
    A-65317
    		Inhibitor
    A-65317 is a primate-selective renin dipeptide inhibitor (IC50 of 0.37 nM) with long hypotensive response.
    A-65317
  • HY-136676
    Cgp 38560 methanesulfonate
    		Inhibitor
    Cgp 38560 methanesulfonate is a well-tolerated renin inhibitor. Cgp 38560 methanesulfonate caused a dose-dependent decrease in angiotensin II and plasma renin activity, and a dose-dependent increase in active renin.
    Cgp 38560 methanesulfonate
  • HY-120756
    PD125754
    		Inhibitor
    PD125754 is an oligopeptide renin inhibitor (IC50: 22 nM).
    PD125754
  • HY-117913
    ES-8891
    ES-8891 is a renin inhibitor. Oral administration of ES-8891 to normotensive sodium-depleted macaques for one week significantly reduced plasma renin activity, immunoreactive renin concentrations, and plasma angiotensin I concentrations, while mean blood pressure decreased significantly, without significant changes in heart rate. ES-8891 regulates blood pressure by inhibiting plasma renin levels and renal renin synthesis.
    ES-8891
  • HY-120586
    SC-46944
    		Inhibitor
    SC-46944 is an orally active renin inhibitor and can be used for study of hypertension.
    SC-46944
  • HY-125625
    ES 6864
    		Inhibitor
    ES 6864 is an orally active, competitive inhibitor for human renin, with an IC50 of 6.9 nM and a Ki of 7.3 nM. ES 6864 exhibits high species-specific and enzyme-specific properties. ES 6864 exhibits metabolic stability in rat tissue homogenates. ES 6864 reduces blood pressure in rats and sodium-depleted awake marmosets.
    ES 6864
  • HY-N2115R
    Araloside A (Standard)
    		Inhibitor
    Araloside A (Standard) is the analytical standard of Araloside A. This product is intended for research and analytical applications. Araloside A (Chikusetsusaponin IV) is a component of Panax japonicus, with low-renin-inhibitory activity, with an IC50 of 77.4 μM.
    Araloside A (Standard)
  • HY-U00262
    ACT 178882
    		Inhibitor
    ACT 178882 is a new Renin inhibitor with an IC50 of 1.4 nM.
    ACT 178882