2. Signaling Pathways
  3. Epigenetics
  4. SF3B1

SF3B1

Splicing Factor 3b Subunit 1

 
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-16399
    Pladienolide B
    		Inhibitor ≥99.0%
    Pladienolide B is a potent cancer cell growth inhibitor that targets the SF3B1 subunit of the spliceosome. Pladienolide B exerts antitumor activities mediated through the inhibition of pre-mRNA splicing. Pladienolide B induces apoptosis.
    Pladienolide B
  • HY-141881
    PROTAC-O4I2
    		Degrader 99.66%
    PROTAC-O4I2 is a PROTAC targets splicing factor 3B1 (SF3B1). PROTAC-O4I2 induces FLAG-SF3B1 degradation with an IC50 value of 0.244 μM in K562 cells. PROTAC-O4I2 also induces cellular apoptosis in K562 WT cells.
    PROTAC-O4I2
  • HY-111517
    H3B-8800
    		Inhibitor 98.85%
    H3B-8800 is a potent and orally active SF3B splicing modulator. H3B-8800 direct interaction with the SF3b complex and shows anti-cancer activity. H3B-8800 has the potential for the research of acute myeloid leukemia (AML) with SF3B1 mutant.
    H3B-8800
  • HY-16466
    Spliceostatin A
    Spliceostatin A, the FR901464 (HY-16212) methylated derivative, is a potent anti-tumor agent. Spliceostatin A inhibits splicing and promotes pre-mRNA accumulation by binding SF3B1. SF3B1 is a subcomplex of U2 small nuclear ribonucleoprotein in the spliceosome. Spliceostatin A induces Apoptosis in chronic lymphocytic leukemia (CLL) cells.
    Spliceostatin A
Cat. No. Product Name / Synonyms Application Reactivity