STAT

STAT Isoform Specific Products:

STAT Isoform Comparison

STAT Related Products (414)
Antibodies (25)
STAT Isoform Comparison

By Effects:	Controls (2) Inhibitors (335) Agonists (3) Degraders (9) Antagonist (1) Activators (23) Modulators (4)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-13818

Stattic	Inhibitor	99.58%
Stattic is a potent STAT3 inhibitor and inhibits STAT3 phosphorylation (at Y705 and S727). Stattic inhibits the binding of a high affinity phosphopeptide for the SH2 domain of STAT3. Stattic ameliorates the renal dysfunction in Alport syndrome (AS) mice.

HY-B0069

Fludarabine	Inhibitor	99.85%
Fludarabine (NSC 118218) is a DNA synthesis inhibitor and a fluorinated purine analogue with antineoplastic activity in lymphoproliferative malignancies. Fludarabine inhibits the cytokine-induced activation of STAT1 and STAT1-dependent gene transcription in normal resting or activated lymphocytes.

HY-12000

AG490	Inhibitor	99.86%
AG490 (Tyrphostin AG490) is a tyrosine kinase inhibitor that inhibits EGFR, Stat-3 and JAK2/3.

HY-16141

Cilengitide	Inhibitor	99.80%
Cilengitide (EMD 121974) is a potent integrins antagonist with IC₅₀s of 0.61 nM (α_νβ₃), 8.4 nM (α_νβ₅) and 14.9 nM (α₅β₁), respectively. Cilengitide inhibits the binding of α_νβ₃ and α_νβ₅ to Vitronectin with IC₅₀s of 4 nM and 79 nM, respectively. Cilengitide inhibits TGF-β/Smad signaling, mediates PD-L1 expression. Cilengitide also induces apoptosis, shows antiangiogenic effect in the research against glioblastoma and other cancers.

HY-14944

Homoharringtonine	Inhibitor	99.96%
Homoharringtonine (Omacetaxine mepesuccinate;HHT) is a cytotoxic alkaloid with antitumor properties which acts by inhibiting translation elongation.

HY-169179

AK-1690	Degrader
AK-1690 is a potent and selective STAT6 PROTAC degrader. AK-1690 reduces the levels of STAT6 protein in cells (DC₅₀=1 nM) and depletes STAT6 protein in mouse tissues. AK-1690 can be used for the research of cancer. (Pink: ligand for target protein STAT6 (HY-169182); Black: linker (HY-W459522); Blue: ligand for E3 ligase (HY-131318).

HY-120113

SC-2001	Inhibitor
SC-2001 is a compound structurally related to obatoclax that has better antitumor effects than obatoclax in liver cancer cell lines, downregulating Mcl-1 protein levels, inhibiting STAT3 phosphorylation, inducing apoptosis, and enhancing SHP1 expression and activity.

HY-P10201A

Ac-GpYLPQTV-NH2 acetate	Inhibitor	99.38%
Ac-GpYLPQTV-NH2 acetate is a STAT3 inhibitor with an IC₅₀ value of 0.33 μM. Ac-GpYLPQTV-NH2 acetate has antitumor activity.

HY-100614

AS1517499	Inhibitor	99.17%
AS1517499 is a potent and brain-permeable STAT6 phosphorylation inhibitor with an IC₅₀ of 21 nM.

HY-B0497

Niclosamide	Inhibitor	99.91%
Niclosamide (BAY2353) is an orally active antihelminthic agent used in parasitic infection research. Niclosamide is a STAT3 inhibitor with an IC₅₀ of 0.25 μM in HeLa cells. Niclosamide has biological activities against cancer, inhibits DNA replication in Vero E6 cells.

HY-N0193

Artesunate	Inhibitor	99.84%
Artesunate is an inhibitor of both STAT-3 and exported protein 1 (EXP1).

HY-112288

C188-9	Inhibitor	99.90%
C188-9 (TTI-101) is a STAT3 inhibitor, with a K_d of 4.7 nM. C188-9 inhibits G-CSF-induced STAT3 activation and STAT3-dependent gene expression. C188-9 induces apoptosis in AML cell lines and primary samples and inhibits colony formation by primary AML blasts.

HY-107632

GYY4137	Inhibitor	98.08%
GY4137 is a sustained-release H2S donor possessing vasodilatory, antihypertensive, and anti-inflammatory activities. GY4137 can inhibit cell growth, induce apoptosis, and cause cell cycle arrest by blocking the STAT3 pathway, demonstrating potent anticancer activity.

HY-15146

NSC 74859	Inhibitor	98.35%
NSC 74859 (S3I-201) is a selective Stat3 inhibitor with an IC₅₀ of 86 μM.

HY-N2334

Glycochenodeoxycholic acid	Activator	99.25%
Glycochenodeoxycholic acid (Chenodeoxycholylglycine) is a relatively toxic bile salt generated in the liver from chenodeoxycholic acid and glycine. Glycochenodeoxycholic acid inhibits Autophagosome formation and impairs lysosomal function by inhibiting lysosomal proteolysis and increasing lysosomal pH in human normal liver cells, leading to the Apoptosis of human hepatocyte cells. Glycochenodeoxycholic acid induces stemness and chemoresistance via activating STAT3 signaling pathway in hepatocellular carcinoma cells (HCC). Glycochenodeoxycholic acid is promising for research in the field of cholestasis desease, hepatocellular carcinoma and primary sclerosing cholangitis (PSC).

HY-148748

Butyzamide	Activator	99.62%
Butyzamide is an orally active activator of Mpl, a thrombopoietin (TPO) receptor. Butyzamide increases the phosphorylation level of JAK2, STAT3, STAT5 and MAPK. Butyzamide increases the level of human platelets in mouse xenotransplantation assay.

HY-P1061

Colivelin	Activator	99.27%
Colivelin is a brain penetrant neuroprotective peptide and a potent activator of STAT3, suppresses neuronal death by activating STAT3 in vitro. Colivelin exhibits long-term beneficial effects against neurotoxicity, Aβ deposition, neuronal apoptosis, and synaptic plasticity deficits in neurodegenerative disease. Colivelin has the potential for the treatment of alzheimer's disease and ischemic brain injury

HY-B2163

Astaxanthin	Inhibitor	≥98.0%
Astaxanthin, the red dietary carotenoid, is an orally effective and potent antioxidant. Astaxanthin inhibits NF-κB and down-regulates VEGF in blood glucose. Astaxanthin exerts anti-cancer cell proliferation, increases apoptosis, impairs migration and invasion by activating PPARγ and reducing the expression of STAT3. Astaxanthin also has neuroprotective and anti-inflammatory activity and can be used in studies of cancer, diabetic retinopathy, cardiovascular disease, and in the coloring of animal feed.

HY-10074

TPCA-1	Inhibitor	99.66%
TPCA-1 is a potent and selective inhibitor of IKK-2 with IC₅₀ of 17.9 nM. TPCA-1 is an effective inhibitor of STAT3 phosphorylation, DNA binding, and transactivation.

HY-15312

WP1066	Inhibitor	99.77%
WP1066 is an inhibitor of JAK2 and STAT3, and also shows effect on STAT5 and ERK1/2, without affecting JAK1 and JAK3.

Stattic	STAT3				99.58%
AG490	Stat-3				99.86%
Cilengitide	STAT3 (^[3])				99.80%
Homoharringtonine	STAT3				99.96%
Ac-GpYLPQTV-NH2 acetate	STAT3, IC₅₀: 0.33 μM				99.38%
AS1517499			STAT6, IC₅₀: 21 nM		99.17%
Niclosamide	STAT3, IC₅₀: 0.25 μM (in HeLa cells)				99.91%
Artesunate	Stat-3				99.84%
C188-9	STAT3, Kd: 4.7 nM				99.90%
GYY4137	Stat-3				98.08%
NSC 74859	STAT3, IC₅₀: 86 μM				98.35%
Butyzamide	STAT3	STAT5			99.62%
Colivelin	STAT3				99.27%
Astaxanthin	STAT3				≥98.0%
TPCA-1	STAT3				99.66%
WP1066	STAT3				99.77%
Scutellarin	STAT3				99.04%
Napabucasin	STAT3				99.94%
Cryptotanshinone	STAT3, IC₅₀: 4.6 μM				98.80%
STAT5-IN-1		STAT5β, IC₅₀: 47 μM			98.35%
Pimozide	STAT3	STAT5			99.91%
Colivelin TFA	STAT3				99.52%
SD-36	STAT3, Kd: 50 nM				99.73%
Diosgenin	STAT3				99.35%
Saikosaponin D	STAT3				98.76%
AC-4-130		STAT5			99.93%
Cucurbitacin I	STAT3				99.44%
AS2863619		STAT5			99.94%
Morusin	STAT3				99.94%
SH-4-54	STAT3, Kd: 300 nM	STAT5, Kd: 464 nM			99.45%
Alantolactone	STAT3				99.94%
BP-1-102	STAT3, IC₅₀: 6.8 μM				99.52%
SI-109	STAT3, Ki: 9 nM				99.91%
Nifuroxazide	STAT3				99.90%
SC-43	p-STAT3				99.02%
YM-341619			STAT6, IC₅₀: 0.70 nM		99.06%
STAT3-IN-1	Stat-3, IC₅₀: 1.82 μM (in HT29 cells) Stat-3, IC₅₀: 2.14 μM (in MDA-MB 231 cells)
AK-2292		STAT5, DC₅₀: 0.10 μM			99.73%
AS1810722			STAT6, IC₅₀: 1.9 nM		98.14%
Erasin	STAT3, IC₅₀: 9.7 μM			STAT1, IC₅₀: 24 μM
NSC-370284	STAT3	STAT5
1-Stearoyl-sn-glycero-3-phosphocholine	p-STAT3				99.53%
Peramivir	STAT3				99.32%
Atractylenolide II	p-STAT3				99.94%
Stafia-1		STAT5a, Ki: 10.9 μM STAT5a, IC₅₀: 22.2 μM			99.37%
Brevilin A	STAT3, IC₅₀: 10.6 μM				99.81%
Broussonin E	STAT3				98.18%
Flubendazole	STAT3				99.33%
HJC0152	STAT3				99.76%
STAT3-IN-3	STAT3				98.40%
HO-3867	STAT3				99.67%
Perindopril erbumine	STAT3				99.98%
BD750		STAT5			99.10%
Picroside I			STAT6		99.55%
LLL12	p-STAT3				99.45%
GMB-475		STAT5			98.98%
STX-0119	STAT3, IC₅₀: 74 μM (STAT3 transcription)				99.21%
Garcinone D	p-STAT3				99.88%
Stafib-1		STAT5b, IC₅₀: 154 nM			≥98.0%
OSM-SMI-10B	p-STAT3				99.28%
IST5-002		STAT5a, IC₅₀: 1.5 μM STAT5b, IC₅₀: 3.5 μM			99.36%
Cenisertib		STAT5			99.86%
inS3-54A18	STAT3				99.53%
STAT3-IN-25	STAT3				99.36%
Triacetylresveratrol	STAT3				99.58%
Ginkgolic acid C17:1	STAT3				99.90%
Mogrol	STAT3				99.76%
Corylifol A	STAT3, IC₅₀: 0.81 μM				99.90%
STAT3-IN-12	STAT3				99.92%
STAT5-IN-2		STAT5, EC₅₀: 9 μM (in K562 cells) STAT5, EC₅₀: 5 μM (in KU812 cells )			99.08%
Ochromycinone	STAT3				98.29%
Perindopril	STAT3				98.11%
Reticuline	STAT3				98.91%
Golotimod hydrochloride	STAT3				99.79%
Garcinone C	Stat-3				99.66%
Arnicolide D	STAT3				99.69%
HODHBt		STAT5			99.93%
Protosappanin A	STAT3				99.98%
LL-K8-22				STAT1	99.76%
Tetramethylcurcumin	STAT3				99.91%
Balsalazide	STAT3				99.34%
STAT3-IN-15	STAT3				98.99%
YMU1	STAT3				99.19%
KT-333	STAT3
HJC0416 hydrochloride	STAT3				98.68%
AS2863619 free base		STAT5			99.87%
STAT3-IN-17	STAT3				≥98.0%
SC99	STAT3				98.96%
Golotimod	STAT3				98.04%
PROTAC FLT-3 degrader 1		STAT5			99.74%
ASP3026	STAT3				99.88%
OK2	p-STAT3
Equisetin	STAT3				99.40%
1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea	p-STAT3				98.02%
SB02024				STAT1	99.7%
Balsalazide sodium hydrate	STAT3				99.61%
WB436B	STAT3				99.93%
MNK8	STAT3				99.76%
ENMD-1198	STAT3				98.87%
UC-514321	STAT3	STAT5			≥98.0%
SH5-07	STAT3, IC₅₀: 3.9 μM				≥98.0%
Syk-IN-6	STAT3	STAT5
SD-1029	STAT3
Vanicoside B	STAT3				99.82%
APTSTAT3-9R	STAT3				99.55%
Iminostilbene	STAT3				99.34%
Pimozide-d₄	STAT3	STAT5			≥98.0%
Galiellalactone	STAT3, IC₅₀: 250-500 nM
Biflorin				STAT1	99.54%
Stafia-1-dipivaloyloxymethyl ester		STAT5a			98.31%
Eupalinolide K	STAT3				99.20%
Eflepedocokin alfa	STAT3				≥99.0%
Niclosamide monohydrate	STAT3, IC₅₀: 0.25 μM (in HeLa cells)
SD-1008	STAT3				99.10%
STAT3-IN-8	STAT3
KT-333 diammonium	STAT3
YSY01A	Stat-3
c-Met-IN-24	STAT3, IC₅₀: 4.7 μM
STAT3-IN-37	STAT3
STAT3 HiBiT degrader 1	STAT3
STAT3-IN-38	STAT3, Kd: 45.33 μM
STAT3-IN-29	STAT3
VEGFR-2/STAT-3-IN-1	STAT3, IC₅₀: 5.63 nM
8α-Tigloyloxyhirsutinolide 13-O-acetate	STAT3
STAT1/3-IN-1	STAT3			STAT1
KT-333 ammonium	STAT3
WR-S-462	STAT3, Kd: 58 nM
JAK1/STAT3-IN-1	STAT3
FLT3-IN-28		STAT5
SD-436	STAT3, IC₅₀: 19 nM	STAT5, IC₅₀: >10 μM	STAT6, IC₅₀: >10 μM	STAT1, IC₅₀: 270 nM
STAT3/AKT-IN-1	Stat-3
ROCK2-IN-7	Stat-3
Anti-inflammatory agent 92	STAT3
STAT3-IN-41	STAT3
Golotimod TFA	STAT3
HJC0416	STAT3
HJC0123	STAT3
HAT-SIL-TG-1&AT	STAT3	STAT5
7-epi-Isogarcinol	STAT3
Cernuumolide J	Stat-3
Atractylenolide II (Standard)	p-STAT3
Antitumor agent-73	STAT3
STAT3-IN-5	p-STAT3, EC₅₀: 170 nM
K882	Stat-3
STAT3-IN-32	STAT3
WB518	STAT3 p-STAT3
Hsp110-STAT3 interaction-IN-2	STAT3
Ac-GpYLPQTV-NH2	STAT3, IC₅₀: 0.33 μM
STAT3-IN-9	STAT3
PROTAC STAT3 degrader-2	STAT3, ID₅₀: 3.54 μM
Ascochlorin	STAT3
Tyk2-IN-22-d₃		STAT5
1-Stearoyl-sn-glycero-3-phosphocholine-d₃₅	p-STAT3
NW16	STAT3, Kd: 11.0 μM
15(R)-Lipoxin A4			STAT6
Furowanin A	STAT3
Antitumor agent-195	STAT3, IC₅₀: 0.52 μM
STAT3-IN-10	STAT3, IC₅₀: 5.18 μM
Balsalazide disodium	STAT3
GYY4137 (GMP)	Stat-3
CHMFL-48		STAT5
DETD-35	Stat-3
STAT3-IN-39	STAT3
TM-233	Stat-3
BP-1-108		STAT5, Ki: 8.3 μM
PMMB-187	Stat-3, IC₅₀: 1.81 μM

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STAT

STAT

STAT Isoform Specific Products:

STAT Isoform Specific Products:

STAT Related Products (414)

Antibodies (25)

STAT Isoform Comparison

STAT Related Products (414):