2. Signaling Pathways
  3. Cell Cycle/DNA Damage
    Epigenetics
  4. Sirtuin

Sirtuin

Sirtuin

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Sirtuin (Sir2 proteins) are a class of proteins that possess either mono-ADP-ribosyltransferase, or deacylase activity, including deacetylase, desuccinylase, demalonylase, demyristoylase and depalmitoylase activity. Sirtuins regulate important biological pathways in bacteria, archaeaand eukaryotes. Sirtuins have been implicated in influencing a wide range of cellular processes like aging, transcription, apoptosis, inflammation and stress resistance, as well as energy efficiency and alertness during low-calorie situations. Sirtuins can also control circadian clocks and mitochondrial biogenesis.

Sirtuin Isoform Specific Products:

Sirtuin Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-149525
    SIRT5 inhibitor 9
    		Inhibitor
    SIRT5 inhibitor 9 (compound 14) is a competitive inhibitor (IC50: 4.07 μM) of sirtuin SIRT5 with anticancer potential.
    SIRT5 inhibitor 9
  • HY-150727
    SIRT5 inhibitor 4
    		Inhibitor
    SIRT5 inhibitor 4 (compound 11) is a potent, selective SIRT5 inhibitor with IC50 values of 26.4 and >400μM for SIRT5 and other SIRT subtype, respectively.
    SIRT5 inhibitor 4
  • HY-123033AR
    Nicotinamide riboside chloride (Standard)
    		Activator
    Nicotinamide riboside (chloride) (Standard) is the analytical standard of Nicotinamide riboside (chloride). This product is intended for research and analytical applications. Nicotinamide riboside Chloride, an orally active NAD+ precursor, increases NAD+ levels and activates SIRT1 and SIRT3. Nicotinamide riboside Chloride is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities[1]. Nicotinamide riboside Chloride reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease[2].
    Nicotinamide riboside chloride (Standard)
  • HY-123033B
    Nicotinamide riboside tartrate
    		Activator
    Nicotinamide riboside tartrate, an orally active NAD+ precursor, increases NAD+ levels and activates SIRT1 and SIRT3. Nicotinamide riboside tartrate is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities. Nicotinamide riboside tartrate reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease.
    Nicotinamide riboside tartrate
  • HY-169159
    SIRT6 activator 2
    		Activator
    SIRT6 activator 2 (compound 31) is a sirtuin 6 activator with anti-lipid accumulation properties. SIRT6 activator 2 significantly downregulates LXR, SREBP-1c, and their target genes associated with lipogenesis, and can be used for research related to lipid metabolism-related diseases.
    SIRT6 activator 2
  • HY-RS12955
    Sirt7 Rat Pre-designed siRNA Set A
    		Inhibitor

    Sirt7 Rat Pre-designed siRNA Set A contains three designed siRNAs for Sirt7 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Sirt7 Rat Pre-designed siRNA Set A
    Sirt7 Rat Pre-designed siRNA Set A
  • HY-155392
    Mz325
    		Inhibitor
    Mz325 is a dual inhibitor of HDAC and Sirt2, with the IC50 of 9.7 μM to Sirt2, that play an important role in pathogenesis of cancer and neurodegeneration.
    Mz325
  • HY-119857
    AGK7
    AGK7 is a potent inhibitor of sirtuin 2 (SIRT2). AGK7 rescues alpha-synuclein toxicity and modified inclusion morphology in a cellular model of Parkinson's disease. AGK7 protects against dopaminergic cell death both in vitro and in a Drosophila model of Parkinson's disease.
    AGK7
  • HY-146013
    Sirt1/2-IN-1
    		Inhibitor
    Sirt1/2-IN-1 (Compound 7) is a SIRT1 and SIRT2 inhibitor with IC50 values of 1.81, 2.10 and 20.5 µg/mL against SIRT1, SIRT2 and SIRT3, respectively. Sirt1/2-IN-1 displays activity in hyperacetylation of α-tubulin protein with an IC50 of 32.05 µg/mL. Sirt1/2-IN-1 shows prominent anticancer activity.
    Sirt1/2-IN-1
  • HY-156023
    Sirtuin modulator 7
    		Modulator 99.28%
    Sirtuin modulator 7 is a sirtuin-modulating compound which may increase the lifespan of a cell, and may be used for research of diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and flushing which would benefit from increased mitochondrial activity.
    Sirtuin modulator 7
  • HY-163676
    MI-217
    		Inhibitor
    MI-217 is a potent SIRT3 inhibitor. MI-217 induces MDA-MB-231 apoptosis. MI-217 can be used in the study of breast cancer.
    MI-217
  • HY-169051
    SIRT-IN-5
    		Inhibitor
    SIRT-IN-5 is a SIRT3 inhibitor, with an IC50 value of 2.88 μM. SIRT-IN-5 can promote the differentiation of multiple myeloma cells, along with an increase in the expression of the differentiation antigen CD49e and human immunoglobulin light chains λ and κ.
    SIRT-IN-5
  • HY-148312
    Sirtuin modulator 4
    		Inhibitor
    Sirtuin modulator 4 (compound 12) is a sirtuin modulator. Sirtuin modulator 4 shows inhibitory effect to SIRT1 with an EC50 value of 51-100 μM. Sirtuin modulator 4 may be used for the research of increasing the lifespan of a cell, and preventing a wide variety of diseases and disorders including, for example, diabetes, obesity, neurodegenerative diseases, cardiovascular diseases, inflammation and cancer.
    Sirtuin modulator 4
  • HY-149638
    HSP70/SIRT2-IN-2
    		Inhibitor
    HSP70/SIRT2-IN-2 (Compounds 1a) is a dual inhibitor for SIRT2 and HSP70, with IC50 of 45.1±5.0 μM for SIRT2. HSP70/SIRT2-IN-2 has antitumor activity.
    HSP70/SIRT2-IN-2
  • HY-136204
    Resveratrol analog 2
    		Agonist
    Resveratrol analog 2 is an analog of Resveratrol (HY-16561). Resveratrol is a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties.
    Resveratrol analog 2
  • HY-169809
    SIRT1-IN-5
    		Inhibitor
    SIRT1-IN-5 (215) is a NAD-dependent protein deacetylase sirtuin-1 modulator.
    SIRT1-IN-5
  • HY-160617
    SIRT2-IN-14
    		Inhibitor
    SIRT2-IN-14 (Compound 78) is a selectve inhibitor for SIRT2 with an IC50 of 0.196 μM.
    SIRT2-IN-14
  • HY-155729
    Sirt1/2-IN-4
    		Inhibitor
    Sirt1/2-IN-4 (compound PS3) is a triple inhibitor of SIRT1/2/3 with IC50s of 1.2 μM (SIRT1), 1.9 μM (SIRT2), and 18.6 μM (SIRT3), respsectivley. Sirt1/2-IN-4 completely blocks p53 deacetylation, with potential anti-cancer activity.
    Sirt1/2-IN-4
  • HY-RS12949
    Sirt5 Rat Pre-designed siRNA Set A
    		Inhibitor

    Sirt5 Rat Pre-designed siRNA Set A contains three designed siRNAs for Sirt5 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Sirt5 Rat Pre-designed siRNA Set A
    Sirt5 Rat Pre-designed siRNA Set A
  • HY-RS12954
    Sirt7 Mouse Pre-designed siRNA Set A
    		Inhibitor

    Sirt7 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sirt7 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Sirt7 Mouse Pre-designed siRNA Set A
    Sirt7 Mouse Pre-designed siRNA Set A
Cat. No. Product Name / Synonyms Application Reactivity
Sirtuin Isoform Comparison

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