2. Signaling Pathways
  3. Cell Cycle/DNA Damage
    Epigenetics
  4. Sirtuin
  5. SIRT2 Isoform
  6. SIRT2 Inhibitor

SIRT2 Inhibitor

SIRT2 Inhibitors (47):

Cat. No. Product Name Effect Purity
  • HY-146013
    Sirt1/2-IN-1
    		Inhibitor
    Sirt1/2-IN-1 (Compound 7) is a SIRT1 and SIRT2 inhibitor with IC50 values of 1.81, 2.10 and 20.5 µg/mL against SIRT1, SIRT2 and SIRT3, respectively. Sirt1/2-IN-1 displays activity in hyperacetylation of α-tubulin protein with an IC50 of 32.05 µg/mL. Sirt1/2-IN-1 shows prominent anticancer activity.
  • HY-160617
    SIRT2-IN-14
    		Inhibitor
    SIRT2-IN-14 (Compound 78) is a selectve inhibitor for SIRT2 with an IC50 of 0.196 μM.
  • HY-149637
    HSP70/SIRT2-IN-1
    		Inhibitor
    HSP70/SIRT2-IN-1 (Compounds 2a) is a dual inhibitor for SIRT2 and HSP70, with IC50 of 17.3±2.0 μM for SIRT2. HSP70/SIRT2-IN-1 has antitumor activity.
  • HY-170402
    SIRT6-IN-4
    		Inhibitor
    SIRT6-IN-4 (Compound 10d) is a selective inhibitor for SIRT6 with an IC50 of 5.68 μM. SIRT6-IN-4 inhibits the proliferation of MCF-7 with an IC50 of 8.30 μM. SIRT6-IN-4 arrests the cell cycle at G2/M phase, inhibits thecell migration and invasion of MCF-7, and induces apoptosis. SIRT6-IN-4 exhibits antitumor efficacy in mouse models.
  • HY-117442
    A2B57
    		Inhibitor
    A2B57 is a selective inhibitor for SIRT 2 with an IC50 of 6.3 µM.
  • HY-W109401
    SIRT-IN-6
    		Inhibitor
    SIRT-IN-6 (Compound 14) is a pan-inhibitor of SIRT1/2/3 with IC50 values of >50 μM. SIRT-IN-6 is promising for research of metabolic, inflammatory, oncologic and neurodegenerative disorders.
  • HY-119889
    A1B11
    		Inhibitor
    A1B11 is a selective SIRT inhibitor (SIRT2:IC50=5.3 μM) that can be used in the study of neurodegenerative diseases.