2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Thrombin

Thrombin

Thrombin

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Thrombin is a Na+-activated, serine protease which is activated by the enzymatic cleavage of two sites on prothrombin by activated Factor X. Thrombin exists in two allosteric forms, slow (S) and fast (F), target toward anticoagulant and procoagulant activities.

Thrombin is the main effector protease in primary hemostasis by activating platelets and plays a key role in secondary hemostasis. Besides its well-known functions in hemostasis, thrombin also plays a role in various non-hemostatic biological and pathophysiologic processes, predominantly mediated through activation of protease-activated receptors (PARs). PAR-1, PAR-3, and PAR-4 are cleaved by thrombin, whereas PAR-2 is cleaved by trypsin. Thrombin also plays a crucial role in the migration and metastasis of human cancer cells.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-12586
    AZD6564
    		Inhibitor
    AZD6564 is an orally active inhibitor for fibrinolysis through disruption of plasma kinase-fibrin interaction. AZD6564 dissolves human plasma clot with an IC50 of 0.44 μM. AZD6564 ameliorates hemorrhage in rats with EC50 of 1.62 μM, and exhibits good pharmacokinetic characteristics in rats.
    AZD6564
  • HY-P4593
    Z-Gly-Pro-Arg-4MβNA
    Z-Gly-Pro-Arg-4MβNA is the cleavage of the substrate of thrombin to release free 4-methoxy-2-naphthylamine (4MβNA). Free 4MβNA can be captured by 5-nitrosalicylaldehyde to produce an insoluble yellow fluorescent and marks the site of thrombin activity.
    Z-Gly-Pro-Arg-4MβNA
  • HY-10163S3
    Dabigatran-13C,d3
    		Inhibitor
    Dabigatran-13C,d3 is the 13C- and deuterium labeled Dabigatran. Dabigatran (BIBR 953), an oral anticoagulant, is a reversible, potent, competitive direct thrombin inhibitor (Ki=4.5 nM). Dabigatran (BIBR 953) also inhibits thrombin-induced platelet aggregation (IC50=10 nM)[1][2].
    Dabigatran-<sup>13</sup>C,d<sub>3</sub>
  • HY-120563
    LY135305
    		Inhibitor
    LY 135305 is a thrombin activation inhibitor. LY 135305 inhibits spontaneous metastasis and increases animal survival.
    LY135305
  • HY-19373
    RWJ-445167
    		Inhibitor
    RWJ-445167 (3DP-10017) is a dual inhibitor of thrombin and factor Xa with Ki of 4.0 nM and 230 nM, respectively, exhibiting potent antithrombotic activity.
    RWJ-445167
  • HY-B0209S
    Metolazone-d7
    		Inhibitor 99.90%
    Metolazone-d7 is deuterium labeled Metolazone. Metolazone (SR-720-22) is primarily used to treat congestive heart failure and high blood pressure.
    Metolazone-d<sub>7</sub>
  • HY-125528
    Ro 09-1679
    		Inhibitor
    Ro 09-1679 is a thrombin inhibitor, with an IC50 of 33.6 μM. Ro 09-1679 inhibits the enzyme activities, with IC50 values of 3.3, 0.04 and 0.0346 μM for factor Xa, trypsin and papain, respectively.
    Ro 09-1679
  • HY-114164G
    Murine Thrombin
    Murine Thrombin is a Na+-activated, allosteric serine protease that plays opposing functional roles in blood coagulation. Thrombin recognition sequence and can be used to digest GST-tagged proteins.
    Murine Thrombin
  • HY-10163S2
    Dabigatran-13C6
    Dabigatran-13C6 is the 13C labeled Dabigatran[1]. Dabigatran (BIBR 953), an oral anticoagulant, is a reversible, potent, competitive direct thrombin inhibitor (Ki=4.5 nM). Dabigatran (BIBR 953) also inhibits thrombin-induced platelet aggregation (IC50=10 nM)[2][3].
    Dabigatran-<sup>13</sup>C<sub>6</sub>
  • HY-170485
    Thrombin inhibitor 13
    		Inhibitor
    Thrombin inhibitor 13 (Compound 13a) is a covalent and reversible inhibitor for thrombin (FIIa) with an IC50 of 0.7 nM. Thrombin inhibitor 13 prolongs the activated partial thromboplastin time (aPTT) and prothrombin time (PT), exhibits antithrombotic and anticoagulant activities.
    Thrombin inhibitor 13
  • HY-111766
    YD-3
    YD-3 is a platelet activation inhibitor. YD-3 inhibits Thrombine-induced rabbit platelets aggregation (IC50: 28.3 μM) and phosphoinositol production. In addition, YD-3 also inhibits Trypsin-induced platelet aggregation in human and rabbit with the IC50 of 38.1 μM and 5.7 μM, respectively, but does not affect the proteolytic activity of trypsin.
    YD-3
  • HY-122052
    UK‑396082
    		Inhibitor
    UK‑396082 is a potent thrombin activated fibrinolytic inhibitor (TAFI) inhibitor. UK‑396082 increases plasmin activity and induces a parallel decrease in ECM levels. UK‑396082 can be used in research of chronic kidney disease (CKD).
    UK‑396082
  • HY-120491
    L 722151
    		Inhibitor
    L 722151 is a competitive inhibitor for factor XIIIa with Ki of 49 µM. L 722151 accelerates tissue plasminogen activator-catalyzed clot dissolution, and exhibits antithrombotic efficacy.
    L 722151
  • HY-P4349
    Pyr-Arg-Thr-Lys-Arg-AMC
    		Substrate
    Pyr-Arg-Thr-Lys-Arg-AMC is a AMC peptide. AMC is a decapeptide that is specifically hydrolyzed by proteases such as trypsin and thrombin. The AMC peptide can be used to determine the activity of protease and the potency of enzyme inhibitors.
    Pyr-Arg-Thr-Lys-Arg-AMC
  • HY-167858
    LK-732
    		Inhibitor
    LK-732 is a thrombin inhibitor with anti-thrombotic activity.LK-732 has a dose-dependent inhibition of hypercoagulability in the model, with an IC50 of 1.3 mg/kg. LK-732 can be used in cardiovascular and cerebrovascular research.
    LK-732
  • HY-100245
    OM-189
    		Inhibitor
    OM-189 is a selective synthetic thrombin inhibitor.
    OM-189
  • HY-P4795
    Acetyl-Hirudin (55-65) sulfated
    		Inhibitor
    Acetyl-Hirudin (55-65) (sulfated) is a Acetyl-fragment of Hirudin. Hirudin is a thrombin inhibitor with blood anticoagulant property.
    Acetyl-Hirudin (55-65) sulfated
  • HY-149396
    FXIIa-IN-1
    		Inhibitor
    XIIa-IN-1-IN-3 (Compound 22) is a Factor XIIa inhibitor (Kiapp: 97.8 nM). XIIa-IN-1-IN-3 can be used for research of thrombosis.
    FXIIa-IN-1
  • HY-107966
    Heparin calcium (MW 15000-19000)
    		Inhibitor
    Heparin calcium (MW 15000-19000) is an anticoagulant which binds reversibly to antithrombin III (ATIII) to form a heparin-antithrombin III complex. The complex binds to and irreversibly inactivates thrombin and other activated clotting factors IX, X, XI, and XII and prevents the transformation of fibrinogen to fibrin.
    Heparin calcium (MW 15000-19000)
  • HY-134685
    Edoxaban impurity 6
    		Inhibitor ≥98.0%
    Edoxaban impurity 6 is an impurity of Edoxaban. Edoxaban (DU-176) is a selective, potent and orally active factor Xa (FXa) inhibitor with Kis of 0.561 nM and 2.98 nM for free FXa and prothrombinase, respectively. Edoxaban is an anticoagulant agent and can be used for stroke prevention.
    Edoxaban impurity 6
Cat. No. Product Name / Synonyms Application Reactivity