2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Thrombin

Thrombin

Thrombin

Related Products

PDF 0.68 MB

Thrombin is a Na+-activated, serine protease which is activated by the enzymatic cleavage of two sites on prothrombin by activated Factor X. Thrombin exists in two allosteric forms, slow (S) and fast (F), target toward anticoagulant and procoagulant activities.

Thrombin is the main effector protease in primary hemostasis by activating platelets and plays a key role in secondary hemostasis. Besides its well-known functions in hemostasis, thrombin also plays a role in various non-hemostatic biological and pathophysiologic processes, predominantly mediated through activation of protease-activated receptors (PARs). PAR-1, PAR-3, and PAR-4 are cleaved by thrombin, whereas PAR-2 is cleaved by trypsin. Thrombin also plays a crucial role in the migration and metastasis of human cancer cells.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-10271
    Flovagatran sodium
    		Inhibitor
    Flovagatran (TGN 255) sodium is a potent and reversible thrombin inhibitor (Ki: 9 nM). Flovagatran sodium can be used in the research of arterial and venous thrombosis.
    Flovagatran sodium
  • HY-106691
    Pirmagrel
    		Inhibitor
    Pirmagrel is a thrombin synthetase inhibitor. Pirmagrel has inhibitory effects on thrombin secretion stimulated by lipopolysaccharide (HY-D1056).
    Pirmagrel
  • HY-105392
    LB30057
    		Inhibitor
    LB30057 (CI-1028) is an orally active selective thrombin inhibitor with an IC50 value of 0.38 nM for human thrombin. LB30057 can be used in the study of the thrombus model.
    LB30057
  • HY-P0316
    TP508
    		Antagonist
    TP508 is a 23-amino acid nonproteolytic thrombin peptide that represents a portion of the receptor-binding domain of thrombin molecule. TP508 activates endothelial NO synthase (eNOS) and stimulates production of NO in human endothelial cells. TP508 activates endothelial cells and stem cells to revascularize and regenerate tissues.
    TP508
  • HY-U00370
    Thrombin inhibitor 1
    		Inhibitor
    Thrombin inhibitor 1 is a potent thrombin inhibitor (Ki=0.66 nM, 2xaPTT=0.43 μM).
    Thrombin inhibitor 1
  • HY-U00039
    Desethyl KBT-3022
    Desethyl KBT-3022 is the main active metabolite of the new antiplatelet agent, KBT-3022.
    Desethyl KBT-3022
Cat. No. Product Name / Synonyms Application Reactivity