2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Tyrosinase

Tyrosinase

Tyrosinase

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Tyrosinase is a copper-containing metalloprotein belonging to the type-3 copper protein family, together with haemocyanins and catechol oxidases. Tyrosinases are the catalysts in mammals responsible for the formation of melanin in skin and hair color, as well as browning in fruit and vegetables following cell damage.

Tyrosinases are found in various prokaryotes as well as in plants, fungi, arthropods, and mammals and are responsible for pigmentation, wound healing, radiation protection, and primary immune response. Tyrosinases perform two sequential enzymatic reactions: hydroxylation of monophenols and oxidation of diphenols to form quinones which polymerize spontaneously to melanin. In plants, sponges, and many invertebrates, tyrosinases are important for wound healing and primary immune responses; in arthropods, they play a role in sclerotization, and in bacteria, tyrosinases protect DNA from UV damage.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-143450
    Tyrosinase-IN-3
    		Inhibitor
    Tyrosinase-IN-3 (compound 54) is a potent inhibitor of tyrosinase. Tyrosinase is a copper-containing metalloenzyme that is responsible for the rate-limiting catalytic step in the melanin biosynthesis and enzymatic browning. Tyrosinase-IN-3 has the potential for the research of skin whitening agents and food preservatives.
    Tyrosinase-IN-3
  • HY-137000
    4-Prenyloxyresveratrol
    		Inhibitor
    4-Prenyloxyresveratrol, an oxyresveratrol derivative, shows potent tyrosinase inhibitory activity with an IC50 of 0.90 μM.
    4-Prenyloxyresveratrol
  • HY-161612
    Mycosporine 2 glycine
    		Inhibitor
    Mycosporine 2 glycine is an inhibitor for tyrosinase-related protein 1 (TYRP1), that binds TYRP1 with good affinity and stability. Mycosporine 2 glycine stimulates mild to moderate skin and ocular irritancy. Mycosporine 2 glycine is utilized in sunscreen products to cure hyperpigmentation-related diseases.
    Mycosporine 2 glycine
  • HY-172432
    Plodicitinib
    		Inhibitor
    Plodicitinib is a Janus tyrosine kinase 3/TEC family kinase inhibitor with anti-inflammatory activity.
    Plodicitinib
  • HY-143459
    Tyrosinase-IN-5
    		Inhibitor
    Tyrosinase-IN-5 (compound 16c) is a potent inhibitor of tyrosinase with an IC50 of 0.02 μM. Tyrosinase-IN-5 efficiently suppresses the melanogenesis without significant toxicity on cells.
    Tyrosinase-IN-5
  • HY-149404
    Tyrosinase-IN-12
    		99.83%
    Non-competitive tyrosinase inhibitor (Tyrosinase-IN-12) is a potent, non-competitive tyrosinase inhibitor with an IC50 value of 49.33 ± 2.64 µM and Ki value of 31.25 ± 0.25 µM. Non-competitive tyrosinase inhibitor (Tyrosinase-IN-12) have the highest radical scavenging activity to reduce the production of reactive oxygen species (ROS) with an IC50 value of 25.39 ± 0.77 µM. Non-competitive tyrosinase inhibitor (Tyrosinase-IN-12) can be used for anti-browning substances in the food and agricultural sectors.
    Tyrosinase-IN-12
  • HY-143448
    Tyrosinase-IN-1
    		Inhibitor
    Tyrosinase-IN-1 (compound 90) is a potent inhibitor of tyrosinase. Tyrosinase is a copper-containing metalloenzyme that is responsible for the rate-limiting catalytic step in the melanin biosynthesis and enzymatic browning. Tyrosinase-IN-1 has the potential for the research of skin whitening agents and food preservatives.
    Tyrosinase-IN-1
  • HY-N3101
    Pedalitin
    		Inhibitor
    Pedalitin is a inhibitor of tyrosinase（IC50=0.28 mM） and α-glucosidase（IC50=0.29 mM）.
    Pedalitin
  • HY-N10219
    Dihydroaltenuene B
    		Inhibitor
    Dihydroaltenuene B is a potent mushroom tyrosinase inhibitor with an IC50 of 38.33 µM. Dihydroaltenuene B shows the hydrogen bonding interactions between the 3-OH and 4’-OH and the His244, Met280 and Gly281 residues of tyrosinase.
    Dihydroaltenuene B
  • HY-139430
    4-Isopropylcatechol
    		Inhibitor 98.03%
    4-Isopropylcatechol is a potent and irreversible cutaneous depigmenting agent. 4-Isopropylcatechol significantly inhibits protein biosynthesis in mouse melanoma cells containing high levels of tyrosinase. 4-Isopropylcatechol can be use to study hyperpigmentation of skins.
    4-Isopropylcatechol
  • HY-N12875
    Ailancoumarin E
    		Inhibitor
    Ailancoumarin E (Compound 5) is a derivative of Coumarin (HY-N0709). Ailancoumarin E exhibits antifeedant activity toward Plutella xylostella, and inhibits growth of third instar larva. Ailancoumarin E inhibits tyrosinase with IC50 of 14.21 μM.
    Ailancoumarin E
  • HY-N3002R
    α-Arbutin (Standard)
    		Inhibitor
    α-Arbutin (Standard) is the analytical standard of α-Arbutin. This product is intended for research and analytical applications. α-Arbutin (4-Hydroxyphenyl α-D-glucopyranoside) is emerging as popular and effective skin whiteners, acting as tyrosinase inhibitor.
    α-Arbutin (Standard)
  • HY-N10285
    Phaeosphaone D
    		Inhibitor
    Phaeosphaone D is a thiodiketopiperazine alkaloid compound isolated from Phaeosphaeria fuckelii, an endophytic fungus. Phaeosphaone D displays mushroom tyrosinase inhibitory activity with an IC50 value of 33.2 μM.
    Phaeosphaone D
  • HY-162140
    Tyrosinase-IN-21
    		Inhibitor
    Tyrosinase-in-21 (compound 3g) is a tyrosinase inhibitor with IC50 value of 80.93 μM.
    Tyrosinase-IN-21
  • HY-123541
    Tec-IN-6
    		Inhibitor
    Tec-IN-6 (compound 6) is a FGF2 binding to Tec kinase inhibitor, with an IC50 of 8.9 μM (His-FGF2/GST-NΔ173 Tec).
    Tec-IN-6
  • HY-162524
    Tyrosinase-IN-28
    		Inhibitor
    Tyrosinase-IN-28 (Compound 4l) is an inhibitor for tyrosinase with IC50 of 72.55 μM, by affecting both substrate binding and enzyme catalysis.
    Tyrosinase-IN-28
  • HY-W012595R
    Benzylideneacetone (Standard)
    		Inhibitor
    Benzylideneacetone (Standard) is the analytical standard of Benzylideneacetone. This product is intended for research and analytical applications. Benzylideneacetone (Benzalacetone) is an orally active antibiotic, tyrosinase inhibitor, phospholipase A2 inhibitor, and immunosuppressant. Benzylideneacetone has antibacterial activity against some gram-negative plant-pathogenic bacteria. Benzylideneacetone can also be used in the synthesis of chemicals and drugs, and as a flavoring additive for some foods.
    Benzylideneacetone (Standard)
  • HY-158021
    Tyrosinase-IN-26
    		Inhibitor
    Tyrosinase-IN-26 (compound 13) is a uncompetitive tyrosinase inhibitor with the an IC50 value of 68.86 µM. Tyrosinase-IN-26 can suppresses melanogenesis.
    Tyrosinase-IN-26
  • HY-156370
    Tyrosinase-IN-15
    		Inhibitor
    Tyrosinase-IN-15 (Compound 39) is a tyrosinase inhibitor (IC50: 7.12 μM, Ki: 11.8 μM).
    Tyrosinase-IN-15
  • HY-P6294
    Pseudostellarin G
    		Inhibitor
    Pseudostellarin G is a natural cyclic octapeptide. Pseudostellarin G has the activity of inhibiting tyrosinase. Pseudostellarin G can inhibit the production of melanin.
    Pseudostellarin G
Cat. No. Product Name / Synonyms Application Reactivity