2. Signaling Pathways
  3. Vitamin D Related/Nuclear Receptor
  4. VD/VDR

VD/VDR

Vitamin D; Vitamin D receptor

VD/VDR

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Vitamin D is a secosteroidalprohormone, it can be synthesized at sufficient levels in skin, given adequate skin exposure to UV B radiation from sunlight. Vitamin D modulates its biological effects by directly regulating target gene expression through the Vitamin D receptor (VDR), a ligand-regulated transcription factor and a member of the nuclear receptor superfamily. Whether synthesized in the skin or ingested, vitamin D requires two hydroxylation steps to become the biologically active hormone, 1,25-dyhydroxyvitamin D3 [1,25(OH)2D3], a form that signals through the VDR. The hormone-bound VDR modulates target gene transcription in response to vitamin D. VDR acts as a master transcriptional regulator of autophagy. Activation of the VDR by vitamin D induces autophagy and an autophagic transcriptional signature in breast cancer (BC) cells.

There are 2 forms of vitamin D. Vitamin D2 (ergocalciferol) comes from irradiation of the yeast and plant sterol ergosterol, and vitamin D3 (cholecalciferol) is found in oily fish and cod liver oil and is made in the skin. Vitamin D represents vitamin D2 and vitamin D3.

Topical agents containing active vitamin D3 (calcitriol, 1α, 25- dihydroxyvitaminD3, VD3) analogues such as Tacalcitol, Calcipotriol and Maxacalcitol are widely used for psoriasis therapy.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-10002B
    (1R,5Z)-Calcitriol
    		Control
    (1R,5Z)-Calcitriol ((1R,5Z)-1,25-Dihydroxyvitamin D3) is a Calcitriol (HY-10002) isomer. Calcitriol is the most active metabolite of vitamin D and also a vitamin D receptor (VDR) agonist.
    (1R,5Z)-Calcitriol
  • HY-A0245R
    Dihydrotachysterol (Standard)
    		Modulator
    1-Palmitoyl-2-oleoyl-sn-glycero-3-PC (Standard) is the analytical standard of 1-Palmitoyl-2-oleoyl-sn-glycero-3-PC. This product is intended for research and analytical applications. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PC (POPC), a phospholipid, is a major component of biological membranes. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PC is used for the preparation of liposomes and studying the properties of lipid bilayers.
    Dihydrotachysterol (Standard)
  • HY-50919R
    Paricalcitol (Standard)
    		Agonist
    Paricalcitol (Standard) is the analytical standard of Paricalcitol. This product is intended for research and analytical applications. Paricalcitol, a vitamin D analogue, is a vitamin D receptor agonist, used for the prevention and treatment of secondary hyperparathyroidism (excessive secretion of parathyroid hormone) associated with chronic renal failure.
    Paricalcitol (Standard)
  • HY-149899
    VDR agonist 2
    		Agonist
    VDR agonist 2 (compound 16i) is a VDR (vitamin D receptor) agonist that can effectively inhibit TGF-β1-induced activation of hepatic stellate cells (HSC). VDR agonist 2 has significant anti-hepatic fibrosis effects both in vitro and in vivo.
    VDR agonist 2
  • HY-32351AS1
    Calcifediol-13C5 monohydrate
    Calcifediol-13C5 monohydrate is the 13C-labeled Calcifediol monohydrate. Calcifediol monohydrate (25-hydroxy Vitamin D3 monohydrate), is an effective VDR ligand and VD supplement. Calcifediol is a prohormone of the vitamin D endocrine system (VDES) and is hydroxylated in the liver to produce the active form, calcitriol. Calcifediol can rapidly increase serum VD levels.
    Calcifediol-<sup>13</sup>C<sub>5</sub> monohydrate
  • HY-170975
    UG-650
    		Ligand
    UG-650 is a non-Gemini analog of UVB1 that combines the structural features of UVB1 and MC 1288. UG-650 can bind to the vitamin D receptor (VDR) and inhibit the proliferation of MCF-7 cells and the migration of MC3T3-E1 cells.
    UG-650
  • HY-156868
    22-Hydroxyvitamin D3
    22-Hydroxyvitamin D3 a novel vitamin D analog, that displays no vitamin D agonist activity in the intestine or in bone.
    22-Hydroxyvitamin D3
  • HY-15398S4
    Vitamin D3-13C5
    		Activator
    Vitamin D3-13C5 is the deuterium labeled Vitamin D3 (HY-15398). Vitamin D3 (Cholecalciferol) is a naturally occuring form of vitamin D. Vitamin D3 induces cell differentiation and prevents proliferation of cancer cells[1][2].
    Vitamin D3-<sup>13</sup>C<sub>5</sub>
  • HY-106561
    Tioclomarol
    		Antagonist
    Tioclomarol, a coumarin anticoagulant, is a vitamin K antagonist.
    Tioclomarol
  • HY-142129
    Pyrocholecalciferol
    Pyrocholecalciferol, a vitamin D analogue, produced by photochemical transformation of 7-dehydrocholesterol (7-DHC).
    Pyrocholecalciferol
  • HY-A0145R
    Phenprocoumon (Standard)
    		Antagonist
    Phenprocoumon (Standard) is the analytical standard of Phenprocoumon. This product is intended for research and analytical applications. Phenprocoumon is a coumarin derivative that acts as a long acting oral anticoagulant and an antagonist of vitamin K.
    Phenprocoumon (Standard)
  • HY-113958
    Difethialone
    		Inhibitor
    Difethialone (LM-2219) is an anticoagulant rodenticide. Difethialone shows high rodenticide activity in warfarin-sensitive and resistant strains of rats and mice. Difethialone interferes with the circulation of vitamin K in the liver, preventing the synthesis of coagulation factors, resulting in the inability of the blood to coagulate properly, ultimately causing internal bleeding and death. Difethialone can be used in studies of ecological impacts.
    Difethialone
  • HY-10001R
    Calcipotriol (Standard)
    		Chemical
    Calcipotriol (Standard) is the analytical standard of Calcipotriol. This product is intended for research and analytical applications. Calcipotriol is a synthetic VitD3 analogue with a high affinity for the vitamin D receptor.
    Calcipotriol (Standard)
  • HY-117182
    LG190178
    LG190178 is a non-steroidal vitamin D receptor (VDR) ligand that can induce the formation of heterodimer complexes between VDR and retinoid X receptor (RXR), stabilizing the agonistic conformation of the VDR ligand-binding domain and promoting its interaction with co-activators. LG190178 has functions in regulating calcium homeostasis, bone mineralization, as well as cell proliferation, differentiation, and apoptosis, making it useful for research in psoriasis, osteoporosis, and cancer.
    LG190178
  • HY-14863
    Lunacalcipol
    		Agonist
    Lunacalcipol (CTA-018), as a vitamin D analogue, has a dual role in the pathogenesis of Chronic Kidney Disease (CKD), as an agonist of vitamin D receptor and an antagonist of cytochrome P450 enzyme 24-hydroxylase. Lunacalcipol binds to VDR and regulates transcriptional activity of VDR by influencing ligand binding affinity, ligand-dependent coactivator recruitment or inhibitory factor dissociation, efficiency of ligand entry into target cells, tissue specificity and different metabolism of ligand. Lunacalcipol can be used in the study of CKD, especially Secondary Hyperparathyroidism (sHPT).
    Lunacalcipol
  • HY-32348R
    Doxercalciferol (Standard)
    		Activator
    Doxercalciferol (Standard) is the analytical standard of Doxercalciferol. This product is intended for research and analytical applications. Doxercalciferol is a Vitamin D2 analog, acts as an activator of Vitamin D receptor, and prevent renal disease.
    Doxercalciferol (Standard)
  • HY-76542AR
    5,6-trans-Vitamin D2 (Standard)
    		Control
    5,6-trans-Vitamin D2 (Standard) is the analytical standard of 5,6-trans-Vitamin D2. This product is intended for research and analytical applications. 5,6-trans-Vitamin D2 is the isomer of Vitamin D2[1].
    5,6-trans-Vitamin D2 (Standard)
  • HY-75035R
    Calcipotriol Impurity C (Standard)
    		Activator
    Calcipotriol Impurity C (Standard) is the analytical standard of Calcipotriol Impurity C. This product is intended for research and analytical applications.
    Calcipotriol Impurity C (Standard)
  • HY-148698
    2MD
    2MD is an orally active vitamin D analog. 2MD stimulates periosteal bone formation and decreases trabecular bone resorption. Thus 2MD restores trabecular and cortical bone mass and strength. 2MD also regulates intraocular pressure (IOP)-relative genes and reduces IOP in non-human primates.
    2MD
  • HY-10003S
    Alfacalcidol-d7
    		Activator
    Alfacalcidol-d7 is the deuterium labeled Alfacalcidol. Alfacalcidol (1-hydroxycholecalciferol) is a vitamin D active metabolites, acts as a non-selective VDR activator medication, and widely be used in the management of osteoporosis[1][2][3][4].
    Alfacalcidol-d<sub>7</sub>
Cat. No. Product Name / Synonyms Application Reactivity