2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Wee1

Wee1

Wee1

Related Products

PDF 0.13 MB

Wee1 is a nuclear kinase belonging to the Ser/Thr family of protein kinases in the fission yeast Schizosaccharomyces pombe (S. pombe). Wee1 has amolecular mass of 96 kDa and it is a key regulator of cell cycle progression. Wee1 influences cell size by inhibiting the entry into mitosis, through inhibiting Cdk1. Wee1 has homologues in many other organisms, including mammals. Wee1 inhibits Cdk1 by phosphorylating it on two different sites, Tyr15 and Thr14. Cdk1 is crucial for the cyclin-dependent passage of the various cell cycle checkpoints. At least three checkpoints exist for which the inhibition of Cdk1 by Wee1 is important: G2/M checkpoint, Cell size checkpoint, DNA damage checkpoint. Wee1 is shown to phosphorylate histone H2B at tyrosine 37 residue which regulates global expression of histones.

Wee1 Related Products (33):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-10993
    Adavosertib
    		Inhibitor 99.97%
    Adavosertib (AZD-1775; MK-1775) is a potent Wee1 inhibitor with an IC50 of 5.2 nM.
    Adavosertib
  • HY-145817A
    lunresertib
    		Inhibitor 99.90%
    lunresertib (RP-6306) is a potent, selective and orally active PKMYT1 inhibitor with an IC50 of 14 nM. lunresertib shows a high degree of selectivity over other kinases in cellular binding assays. lunresertib shows anticancer effects.
    lunresertib
  • HY-13925
    PD0166285
    		Inhibitor 99.46%
    PD0166285, a substrate of P-gp, is a WEE1 inhibitor and a weak Myt1 inhibitor with IC50 values of 24 and 72 nM, respectively. PD0166285 exhibits an IC50 of 3.433 μM for Chk1.
    PD0166285
  • HY-132295
    Azenosertib
    		Inhibitor 99.96%
    Azenosertib (ZN-c3) is a selective, orally active inhibitor for Wee1 inhibitor (IC50=3.9 nM). Azenosertib exhibits antitumor activity.
    Azenosertib
  • HY-18961
    PD 407824
    		Inhibitor 98.02%
    PD 407824 is a checkpoint kinase Chk1 and WEE1 inhibitor with IC50s of 47 and 97 nM, respectively. PD 407824 is a chemical BMP sensitizer and increases the sensitivity of cells to sub-threshold amounts of BMP4.
    PD 407824
  • HY-163491
    PKMYT1-IN-2
    		Inhibitor
    PKMYT1-IN-2 (compound 2) is a potent PKMYT1 inhibitor with an IC50 of 5.7 nM. PKMYT1-IN-2 inhibits the growth of HCC1569 cells with an IC50 of 22 nM.
    PKMYT1-IN-2
  • HY-161879
    WEE1-IN-9
    		Inhibitor
    WEE1-IN-9 (Compound 1) is a Wee1 inhibitor that can be used in cancer research.
    WEE1-IN-9
  • HY-161880
    WEE1-IN-10
    		Inhibitor
    WEE1-IN-10 (compound 77) is a Wee1 kinase inhibitor. WEE1-IN-10 shows inhibitory activity on LOVO cell growth, with an IC50 of 0.524 μM. WEE1-IN-10 can be used for the research of diseases caused by abnormal activity of Wee1.
    WEE1-IN-10
  • HY-147054
    WEE1-IN-5
    		Inhibitor 99.90%
    WEE1-IN-5 is a potent WEE1 inhibitor with an IC50 value of 0.8 nM. WEE1-IN-5 inhibits phospho-CDC2. WEE1-IN-5 abrogates the G2 check point, increasing sensitivity to DNA damaging agents in cancer cells. WEE1-IN-5 can be used for researching anticancer.
    WEE1-IN-5
  • HY-17583
    Griseofulvin
    		99.05%
    Griseofulvin is an orally active antifungal antibiotic with antitumor activity. Griseofulvin induces apoptosis and G2/M cell cycle arrest in cancer cells. Griseofulvin also has cardiovascular modulatory activity, reducing angina pectoris, relieving hand artery spasm associated with onychomycosis, and peripheral vascular diseases such as shoulder-hand syndrome.
    Griseofulvin
  • HY-148062
    RSS0680
    		98.03%
    RSS0680 (Example 22) is a bifunctional compound targeted protein degradation of kinases. RSS0680 degrades AAK1, CDK1, CDK16, CDK2, CDK4, CDK6, EIF2AK4, GAK, LATSl, LIMK2, MAPK6, MAPKAPK5, MARK2, MARK4, MKNK2, NEK9, RPS6KB1, SIK2, SNRK, STK17A, STK17B, STK35, and WEEl. RSS0680 can be used for research of disease or disorder mediated by aberrant kinase activity.
    RSS0680
  • HY-122113
    PD173952
    		Inhibitor 99.44%
    PD173952 is a tyrosine kinases inhibitor with IC50s of 0.3, 1.7 and 6.6 nM against Lyn, Abl and Csk, respectively. PD173952 is also a potent Myt1 kinase inhibitor with a Ki of 8.1 nM. PD173952 induces apoptosis.
    PD173952
  • HY-145817
    (Rac)-lunresertib
    		Inhibitor 99.72%
    (Rac)-lunresertib (compound 181) is a potent Myt1 inhibitor with an IC50 of <10 nM. (Rac)-lunresertib (compound 181) has anticancer effects.
    (Rac)-lunresertib
  • HY-145817B
    (R)-lunresertib
    		Inhibitor 99.87%
    (R)-lunresertib can be used for the research of Myt1 mediated diseases and kinds of cancer for slowing the progression of cancer. (R)-lunresertib (IC50=1360nM) is less active than (S)-lunresertib (IC50<10nM).
    (R)-lunresertib
  • HY-138239
    WEE1-IN-3
    		Inhibitor 98.64%
    WEE1-IN-3 is a potent Wee1 kinase inhibitor with an IC50 of <10 nM. WEE1-IN-3 has anticancer activities.
    WEE1-IN-3
  • HY-108343
    WEE1-IN-4
    		Inhibitor 99.60%
    WEE1-IN-4 is a potent checkpoint Wee1 kinase inhibitor with an IC50 of 0.011 μM.
    WEE1-IN-4
  • HY-145664
    Myt1-IN-1
    		Inhibitor 98.97%
    Myt1-IN-1 is a potent Myt1 inhibitor with an IC50 of <10 nM. Myt1-IN-1 has anticancer effects (WO2021195782A1; compound 132).
    Myt1-IN-1
  • HY-133618
    Pomalidomide-C3-adavosertib
    		Degrader 99.84%
    Pomalidomide-C3-adavosertib is a rapid and selective PROTAC Wee1 degrader (IC50=3.58 nM). Pomalidomide-C3-adavosertib shows anti-cancer cell proliferation activity, and induces apoptosis.
    Pomalidomide-C3-adavosertib
  • HY-103029
    Bosutinib isomer
    		Inhibitor 99.62%
    Bosutinib isomer is a ligand or inhibitor with high binding affinity for both Wee1 and Wee2, with Kd values of 43.7 ± 10.0 and 4.7 ± 2.3 nM, respectively.
    Bosutinib isomer
  • HY-145666
    Myt1-IN-3
    		Inhibitor 99.14%
    Myt1-IN-3 is a potent Myt1 inhibitor with an IC50s of <10 nM (WO2021195782 A1, compound 95).
    Myt1-IN-3