2. Cell Cycle/DNA Damage PROTAC
  3. Wee1 PROTACs
  4. Pomalidomide-C3-adavosertib

Pomalidomide-C3-adavosertib is a rapid and selective PROTAC Wee1 degrader (IC50=3.58 nM). Pomalidomide-C3-adavosertib shows anti-cancer cell proliferation activity, and induces apoptosis.

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Pomalidomide-C3-adavosertib Chemical Structure

Pomalidomide-C3-adavosertib Chemical Structure

CAS No. : 2414418-49-6

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Based on 1 publication(s) in Google Scholar

Pomalidomide-C3-adavosertib Related Antibodies

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Description

Pomalidomide-C3-adavosertib is a rapid and selective PROTAC Wee1 degrader (IC50=3.58 nM). Pomalidomide-C3-adavosertib shows anti-cancer cell proliferation activity, and induces apoptosis[1].

In Vitro

Pomalidomide-C3-adavosertib (1 nM-10 μM; 24, 48, and 72 h) induces CRBN-dependent anti-proliferative effects and synergized with Olaparib[1].
Pomalidomide-C3-adavosertib (100 nM; 24 h) induces DNA damage, apoptosis, and deregulation of the G2/M checkpoint[1].
Pomalidomide-C3-adavosertib (1 nM-10 μM; 6 h) degrades Wee1 in MOLT4 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pomalidomide-C3-adavosertib Related Antibodies

Cell Proliferation Assay[1]

Cell Line: OVCAR8, COV362, and Kuramochi cells
Concentration: 1 nM-10 μM
Incubation Time: 24, 48, and 72 hours
Result: Degraded Wee1 in OVCAR8 cells, with maximal degradation observed at a 100 nM treatment.

Cell Cycle Analysis[1]

Cell Line: MOLT4 cells
Concentration: 100 nM
Incubation Time: 24 hours
Result: Led to reduced pCDKl Y15, increased apoptosis, and increased unrepaired DNA.

Western Blot Analysis[1]

Cell Line: MOLT4 cells
Concentration: 1 nM-10 μM
Incubation Time: 6 hours
Result: Degraded Wee1 after a 6-hour treatment in MOLT4 cells, and induced the downstream changes expected from Wee1 loss-including a decrease in phosphorylated cyclin-dependent kinase 1 (pCDK1) and an increase in pH 3.
Molecular Weight

799.88

Formula

C42H45N11O6
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1N(CC=C)N(C2=NC(C(O)(C)C)=CC=C2)C3=NC(NC4=CC=C(N5CCN(CCCNC6=CC=CC(C(N7C8CCC(NC8=O)=O)=O)=C6C7=O)CC5)C=C4)=NC=C31
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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Pomalidomide-C3-adavosertib Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pomalidomide-C3-adavosertib2414418-49-6Wee1PROTACsanti-proliferation activityinduce apoptosisMOLT4OVCAR8COV362KuramochiInhibitorinhibitorinhibit

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