Wee1

Related Products

Wee1 is a nuclear kinase belonging to the Ser/Thr family of protein kinases in the fission yeast Schizosaccharomyces pombe (S. pombe). Wee1 has amolecular mass of 96 kDa and it is a key regulator of cell cycle progression. Wee1 influences cell size by inhibiting the entry into mitosis, through inhibiting Cdk1. Wee1 has homologues in many other organisms, including mammals. Wee1 inhibits Cdk1 by phosphorylating it on two different sites, Tyr15 and Thr14. Cdk1 is crucial for the cyclin-dependent passage of the various cell cycle checkpoints. At least three checkpoints exist for which the inhibition of Cdk1 by Wee1 is important: G₂/M checkpoint, Cell size checkpoint, DNA damage checkpoint. Wee1 is shown to phosphorylate histone H2B at tyrosine 37 residue which regulates global expression of histones.

Wee1 Related Products (36):

By Effects:	Inhibitors (28) Degraders (2)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-145666

Myt1-IN-3	Inhibitor	99.14%
Myt1-IN-3 is a potent Myt1 inhibitor with an IC₅₀s of <10 nM (WO2021195782 A1, compound 95).

HY-145665

Myt1-IN-2	Inhibitor
Myt1-IN-2 is a potent Myt1 inhibitor with an IC₅₀ of <10 nM. Myt1-IN-2 has anticancer effects (WO2021195782A1; compound 28).

HY-143342

LEB-03-144
LEB-03-144 is a WEE1 DUBTAC (deubiquitinase-targeting chimera) linking AZD1775 (Adavosertib) to the OTUB1 recruiter EN523 through a C3 alkyl linker. LEB-03-144 shows significant WEE1 stabilization in HEP3B hepatoma cancer cells.

HY-163491

PKMYT1-IN-2	Inhibitor
PKMYT1-IN-2 (compound 2) is a potent PKMYT1 inhibitor with an IC₅₀ of 5.7 nM. PKMYT1-IN-2 inhibits the growth of HCC1569 cells with an IC₅₀ of 22 nM.

HY-160530

WEE1-IN-6	Inhibitor
WEE1-IN-6 (compound 110) is a orally active WEE1 inhibitor with an DC₅₀ value of ≦ 100 nM. WEE1-IN-6 inhibits cell proliferation.

HY-13925A

PD0166285 dihydrochloride	Inhibitor
PD0166285 dihydrochloride, a substrate of P-gp, is a WEE1 inhibitor and a weak Myt1 inhibitor with IC₅₀ values of 24 and 72 nM, respectively. PD0166285 dihydrochloride exhibits an IC₅₀ of 3.433 μM for Chk1.

HY-143340

LEB-03-145
LEB-03-145 is a WEE1 DUBTAC (deubiquitinase-targeting chimera) linking AZD1775 (Adavosertib) to the OTUB1 recruiter EN523 through a C5 alkyl linker.

HY-161871

WEE1-IN-8	Inhibitor
WEE1-IN-8 (Compound 55) is a selective WEE1 inhibitor, with an IC₅₀ of 0.98 nM. WEE1-IN-8 (Compound 55) can be used for the research of Pancreatic cancer, Ovarian cancer, Colorectal cancer, Uterine serous carcinoma, etc.

HY-162849

PKMYT1-IN-3	Inhibitor
PKMYT1-IN-3 (compound 8ma) is a potent and selective PKMYT1 inhibitor with an IC₅₀ value of 16.5 nM. PKMYT1-IN-3 has antitumor activity.

HY-157443

Myt1-IN-4	Inhibitor
Myt1-IN-4 (21) is an orally active and selective MYT1 inhibitor, with an IC₅₀ of 2.6 nM. Myt1-IN-4 (21) possesses antitumor activity.

HY-168180

WEE1-IN-11	Inhibitor
WEE1-IN-11 (Compound 13) is a potent CDK2 inhibitor with an IC₅₀ of 2.0 nM. WEE1-IN-11 inhibits NCI–H446, A427, OVCAR3, C33A,and WiDr cells with IC₅₀s of 93.9, 34.5, 86.7, 23.1, and 85 nM, respectively.

HY-143343

LEB-03-153
LEB-03-153 is a WEE1 DUBTAC (deubiquitinase-targeting chimera) linking AZD1775 (Adavosertib) to the OTUB1 recruiter EN523 through no linker.

HY-163697

WEE1-IN-7	Inhibitor
WEE1-IN-7 (compound 12h) is a potent and orally activeWEE1 inhibitor with an IC₅₀ value of 2.1 nM. WEE1-IN-7 induces apoptosis and cell cycle arrest at the S phase. WEE1-IN-7 shows antitumor activity.

HY-162987

PKMYT1-IN-6	Inhibitor
PKMYT1-IN-6 (compund 98) is a PKMYT1 inhibitor with IC₅₀ less than 50 nM.

HY-10993R

Adavosertib (Standard)	Inhibitor
Adavosertib (Standard) is the analytical standard of Adavosertib. This product is intended for research and analytical applications. Adavosertib (AZD-1775; MK-1775) is a potent Wee1 inhibitor with an IC₅₀ of 5.2 nM.

HY-162986

PKMYT1-IN-4	Inhibitor
PKMYT1-IN-4 (compund 27) is a PKMYT1 inhibitor with IC₅₀ less than 50 nM.

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