2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. ADAMTS
  5. ADAMTS Inhibitor

ADAMTS Inhibitor

ADAMTS Inhibitors (9):

Cat. No. Product Name Effect Purity
  • HY-114996
    ADAMTS-5 Inhibitor
    		Inhibitor 99.30%
    ADAMTS-5 Inhibitor is a potent ADAMTS-5 (aggrecanase-2) inhibitor, with an IC50 of 1.1 µM. ADAMTS-5 Inhibitor shows >40-fold functional selectivity over ADAMTS-4 (aggrecanase-1).
  • HY-137430
    Aldumastat
    		Inhibitor 99.54%
    Aldumastat (GLPG1972; S201086) is a potent, seletive and orally active ADAMTS-5 (IC50=19 nM) inhibitor, and has 8-fold seletivity over ADAMTS-4 (IC50=156 nM). Aldumastat has anticatabolic activity and is used for osteoarthritis research.
  • HY-145061
    ADAMTS-5-IN-3
    		Inhibitor 98.90%
    ADAMTS-5-IN-3 (Example 37-2) is a potent inhibitor of ADAMTS-5 and ADAMTS-4 with IC50s of 8 and 12 nM, respectively. ADAMTS-5-IN-3 can be used for the research of diseases involving degradation of cartilage or disruption of cartilage homeostasis, in particular osteoarthrosis and/or rheumatoid arthritis.
  • HY-168003
    ADAMTS7-IN-1
    		Inhibitor
    ADAMTS7-IN-1 (Compound 3a) is an effective and selective inhibitor of ADAMTS7 with a Ki value of 9 nM. ADAMTS7-IN-1 can be used in the research of atherosclerosis.
  • HY-135710
    ADAMTS-5-IN-2
    		Inhibitor 98.73%
    ADAMTS-5-IN-2 (compound 25) is a potent ADAMTS-5 inhibitor with an IC50 value of 0.71 µM. ADAMTS-5-IN-2 has the potential for the research of modifying osteoarthritis.
  • HY-P99671
    Isecarosmab
    		Inhibitor
    Isecarosmab (M-6495) is an anti-ADAMTS monoclonal antibody (mAb) with a KD value of 3.65 pM. Isecarosmab has chondroprotective and anti-inflammatory activities. Isecarosmab can bind albumin to extend plasma half-life.
  • HY-P4003
    Adamtsostatin 16
    		Inhibitor
    Adamtsostatin 16 is an anti-angiogenic 17-amino acid peptide containing type I thrombospondin motifs.
  • HY-P4002
    Adamtsostatin 18
    		Inhibitor
    Adamtsostatin 18 is an anti-angiogenic peptide derived from proteins containing type I thrombospondin motifs. Adamtsostatin 18 inhibits cell migration and proliferation.
  • HY-P4001
    Adamtsostatin 4
    		Inhibitor
    Adamtsostatin 4 is an anti-angiogenic peptide. Adamtsostatin 4 can be used for the research of anti-angiogenic.