Amino Acid Derivatives

Amino Acid Derivatives are bioactive molecules formed through chemical modifications or metabolic transformations of amino acids. They are widely present in living organisms and play crucial roles in physiological, psychological, and athletic performance.
The functions of these derivatives primarily include enhancing energy supply, regulating neurotransmitters, promoting fat metabolism, and reducing muscle damage. For example, creatine can increase muscle strength, enhance ATP resynthesis, and improve short-duration high-intensity exercise performance; tyrosine, as a precursor of dopamine and norepinephrine, helps enhance cognitive function and improve mood, particularly in sleep deprivation conditions, exhibiting anti-fatigue effects; carnitine facilitates fatty acid oxidation in the heart and skeletal muscles, improving endurance performance; HMB (β-hydroxy-β-methylbutyrate) reduces muscle breakdown and promotes muscle mass gain; while taurine exhibits antioxidant and antihypertensive properties and reduces oxidative stress induced by exercise.
Metabolic abnormalities or improper supplementation of amino acid derivatives may be associated with various diseases. For instance, tyrosine metabolism disorders can disrupt neurotransmitter balance, potentially leading to depression or stress-related disorders; elevated ADMA (asymmetric dimethylarginine) levels can inhibit nitric oxide synthesis, increasing the risk of cardiovascular diseases; carnitine deficiency is linked to certain genetic muscle disorders, impairing fat metabolism and energy production. Additionally, HMB may help slow muscle loss under specific conditions, while taurine intake is associated with improved cardiovascular health. Although some of the effects of these derivatives remain debated, they hold significant potential applications in sports nutrition, neurological regulation, and metabolic health.

References:

[1]. Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-807. [Content Brief]

Amino Acid Derivatives Chemical (1)

Amino Acid Derivatives Related Products (1527):

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-19821

Fmoc-Ile-OH		99.96%
Fmoc-Ile-OH is an isoleucine derivative.

HY-79128

Fmoc-L-Lys (Boc)-OH		99.98%
Fmoc-L-Lys (Boc)-OH is a lysine derivative.

HY-W010964

Fmoc-Hyp(tBu)-OH		99.28%
Fmoc-Hyp(tBu)-OH is a proline derivative.

HY-W010836

Fmoc-Bip(4,4')-OH		99.17%
Fmoc-Bip(4,4')-OH is an alanine derivative.

HY-W011210

Fmoc-Pra-OH		99.93%
Fmoc-Pra-OH is a Glycine (HY-Y0966) derivative. Fmoc-Pra-OH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-59291

Levacetylleucine	Chemical	≥98.0%
Levacetylleucine, an orally bioavailable and brain-penetrant endogenous metabolite, is an acetylated derivative of amino acid leucine. Levacetylleucine is the active form of N-acetyl-leucine (NAL). Levacetylleucine attenuates neuronal death and neuroinflammation in the cortical tissue of mice. Levacetylleucine also potentially improves ameliorates lysosomal and metabolic dysfunction. Levacetylleucine improves compensation of postural symptoms after unilateral chemical labyrinthectomy (UL) in rats. Levacetylleucine is promising for research of neurological manifestations of Niemann-Pick disease type C, traumatic brain injury and neurodegeneration prevention.

HY-101552A

L,L-Dityrosine		99.80%
L,L-Dityrosine (o,o'-Dityrosine) is a constituent of acid hydrolysates of a number of biological materials, including the insect cuticular resilin.

HY-W008079

(S)-2-Amino-6-((tert-butoxycarbonyl)amino)hexanoic acid		≥98.0%
(S)-2-Amino-6-((tert-butoxycarbonyl)amino)hexanoic acid is a lysine derivative.

HY-79131

Fmoc-Phe-OH		99.90%
Fmoc-Phe-OH is a phenylalanine derivative.

HY-Y0511

N,N-Dimethylglycine		≥98.0%
N,N-Dimethylglycine (Dimethylglycine) is a natural N-methylated glycine, is a nutrient supplement and acts as an NMDAR glycine site partial agonist. N,N-Dimethylglycine is a methyl donor, could improve immunity, function as an antioxidant to prevent oxidative stress, and scavenge excess of free radicals. N,N-Dimethylglycine exhibits antidepressant-like and surfactant effects.

HY-I1111

Fmoc-L-Val-OH		99.93%
Fmoc-L-Val-OH is a valine derivative.

HY-Y1166

N-(9-Fluorenylmethoxycarbonyl)glutamic acid α-tert-butyl ester		99.93%
N-(9-Fluorenylmethoxycarbonyl)glutamic acid α-tert-butyl ester is a glutamic acid derivative.

HY-W007941

Fmoc-Ser(tBu)-OH		99.98%
Fmoc-Ser(tBu)-OH is a serine derivative.

HY-W010714

Fmoc-D-Gln(Trt)-OH		99.76%
Fmoc-D-Gln(Trt)-OH is a glutamine derivative.

HY-W004864

Fmoc-(S)-2-(4-pentenyl)Ala-OH		99.92%
Fmoc-(S)-2-(4-pentenyl)Ala-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize biologically active secretin analogs.

HY-W007798

Fmoc-Cys(Trt)-OH		99.98%
Fmoc-Cys(Trt)-OH is a cysteine derivative.

HY-W008876

Fmoc-Pen(Trt)-OH		99.93%
Fmoc-Pen(Trt)-OH is an amino acid derivative with an Fmoc protecting group that can be used to synthesize the inhibitory cystine knot (ICK) peptide ProTx-II.

HY-W142080

α-Methyl-DL-tryptophan		99.92%
α-Methyl-DL-tryptophan (α-Methyltryptophan), a tryptophan derivative, is a selective SLC6A14 blocker. In estrogen receptor (ER)-positive breast cancer cells, α-Methyl-DL-tryptophan inhibits mTOR and activates autophagy and apoptosis. α-Methyl-DL-tryptophan also has the effect of reducing weight.

HY-W023493

DL-Allylglycine		≥98.0%
DL-Allylglycine (2-Aminopent-4-enoic acid) is a glutamate decarboxylase (GAD) inhibitor. DL-Allylglycine has convulsant activity that can be used in studies to induce epileptic seizures.

HY-141447

Z-LYS-SBZL monohydrochloride		99.83%
Z-LYS-SBZL (monohydrochloride) is a lysine derivative.

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