2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
  4. Amino acid Transporter
  5. Amino acid Transporter Inhibitor

Amino acid Transporter Inhibitor

Amino acid Transporter Inhibitors (8):

Cat. No. Product Name Effect Purity
  • HY-120139
    KMH-233
    		Inhibitor 98.11%
    KMH-233, a potent, reversible and selective inhibitor of l-type amino acid transporter LAT1/SLC7A5, inhibits the uptake of LAT1 substrate, l-leucin (IC50=18 μM) as well as cell growth. KMH-233 significantly potentiates the efficacy of Bestatin and Cisplatin even at low concentrations (25 μM).
  • HY-W402682
    SXC2023
    		Inhibitor 99.83%
    SXC2023 is an inhibitor for solute carrier family 7 member 11 (SLC7A11). SXC2023 exhibits antitumor efficacy, and ameliorates central nervous system disorder through downregulation of glutamate export.
  • HY-161137
    LQFM215
    		Inhibitor 99.91%
    LQFM215 is a proline transporter (PROT) inhibitor. LQFM215 inhibits proline transport by competitively binding to the active site of PROT. LQFM215 effectively reduces hyperlocomotion and enhances social interaction.
  • HY-156682
    JNT-517
    		Inhibitor 99.00%
    JNT-517 is an orally active, selective SLC6A19 allosteric inhibitor with an IC50 of 47 nM for human SLC6A19. JNT-517 can be used for the study of phenylketonuria (PKU).
  • HY-153763
    PROT-IN-1
    		Inhibitor ≥98.0%
    PROT-IN-1 (Compound 2) is a proline transporter (PROT) inhibitor (IC50: 1.48 μM). PROT-IN-1 can be used for research of cognitive disorders.
  • HY-158161
    SLC6A19-IN-1
    		Inhibitor
    SLC6A19-IN-1 (Compound 16) is a SLC6A19 inhibitor. SLC6A19-IN-1 can be used to study diseases with abnormal amino acid levels, such as phenylketonuria (PKU).
  • HY-117251
    LP-403812
    		Inhibitor
    LP-403812 is a high affinity proline transporter (PROT) inhibitor that produces dose-dependent inhibition of hPROT (IC50=0.11 μM; Ki=0.12 μM) and also inhibits the activity of mouse brain synaptosomal mPROT with the same potency (IC50=0.23 μM). LP-403812 can be used to study the function of PROT in the brain.
  • HY-113745
    LX-6171
    		Inhibitor
    LX-6171 is an orally active SLC6A7 inhibitor. LX-6171 can be used to study diseases characterized by cognitive impairment, such as Alzheimer's disease, schizophrenia or vascular dementia.